小柯机器人

美国圣路易斯华盛顿大学Nico U. F. Dosenbach等研究人员合作发现，可重复的全脑关联研究需要数以千计的个体。2022年3月16日，《自然》杂志在线发表了这项成果。

Author: Marek, Scott, Tervo-Clemmens, Brenden, Calabro, Finnegan J., Montez, David F., Kay, Benjamin P., Hatoum, Alexander S., Donohue, Meghan Rose, Foran, William, Miller, Ryland L., Hendrickson, Timothy J., Malone, Stephen M., Kandala, Sridhar, Feczko, Eric, Miranda-Dominguez, Oscar, Graham, Alice M., Earl, Eric A., Perrone, Anders J., Cordova, Michaela, Doyle, Olivia, Moore, Lucille A., Conan, Gregory M., Uriarte, Johnny, Snider, Kathy, Lynch, Benjamin J., Wilgenbusch, James C., Pengo, Thomas, Tam, Angela, Chen, Jianzhong, Newbold, Dillan J., Zheng, Annie, Seider, Nicole A., Van, Andrew N., Metoki, Athanasia, Chauvin, Roselyne J., Laumann, Timothy O., Greene, Deanna J., Petersen, Steven E., Garavan, Hugh, Thompson, Wesley K., Nichols, Thomas E., Yeo, B. T. Thomas, Barch, Deanna M., Luna, Beatriz, Fair, Damien A., Dosenbach, Nico U. F.

Issue&Volume: 2022-03-16

Abstract: Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping of abilities to specific structures (for example, lesion studies) and functions1,2,3 (for example, task functional MRI (fMRI)). Mental health research and care have yet to realize similar advances from MRI. A primary challenge has been replicating associations between inter-individual differences in brain structure or function and complex cognitive or mental health phenotypes (brain-wide association studies (BWAS)). Such BWAS have typically relied on sample sizes appropriate for classical brain mapping4 (the median neuroimaging study sample size is about 25), but potentially too small for capturing reproducible brain–behavioural phenotype associations5,6. Here we used three of the largest neuroimaging datasets currently available—with a total sample size of around 50,000 individuals—to quantify BWAS effect sizes and reproducibility as a function of sample size. BWAS associations were smaller than previously thought, resulting in statistically underpowered studies, inflated effect sizes and replication failures at typical sample sizes. As sample sizes grew into the thousands, replication rates began to improve and effect size inflation decreased. More robust BWAS effects were detected for functional MRI (versus structural), cognitive tests (versus mental health questionnaires) and multivariate methods (versus univariate). Smaller than expected brain–phenotype associations and variability across population subsamples can explain widespread BWAS replication failures. In contrast to non-BWAS approaches with larger effects (for example, lesions, interventions and within-person), BWAS reproducibility requires samples with thousands of individuals.

DOI: 10.1038/s41586-022-04492-9

Source: https://www.nature.com/articles/s41586-022-04492-9

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html