小柯机器人

人类和小鼠白色脂肪组织的单细胞图谱
2022-03-20 15:42

美国麻省理工学院和哈佛大学的布罗德研究所Evan D. Rosen团队近期取得了重要工作进展,他们成功绘制了人类和小鼠白色脂肪组织的单细胞图谱。该项研究成果2022年3月16日在线发表于《自然》杂志上。

在这里,研究人员在一系列体重范围内以单细胞分辨率提供人类和小鼠皮下和内脏白色脂肪的详细细胞图谱。他们确定了脂肪细胞、脂肪干细胞和祖细胞、血管和免疫细胞的亚群,并证明了不同物种和饮食条件之间的共性和差异。他们将特定的细胞类型与增加的代谢疾病风险联系起来,并为瘦和肥胖中脂肪生态位中单个细胞类型之间的全面相互作用提供了一个初步的蓝图。这些数据构成了一个广泛的资源,用于探索不同物种、不同部位和不同营养条件下白色脂肪组织功能中的基因、性状和细胞类型。

据了解,白色脂肪组织曾经被认为在形态和功能上平淡无奇,但现在被认为是动态的、可塑性的和异质的,并且参与了广泛的生物过程,包括能量稳态、葡萄糖和脂质处理、血压控制和宿主防御。高脂喂养和其他代谢压力源会导致脂肪形态、生理和细胞组成发生显著变化,而肥胖的改变与胰岛素抵抗、血脂异常和2型糖尿病有关。

附:英文原文

Title: A single-cell atlas of human and mouse white adipose tissue

Author: Emont, Margo P., Jacobs, Christopher, Essene, Adam L., Pant, Deepti, Tenen, Danielle, Colleluori, Georgia, Di Vincenzo, Angelica, Jrgensen, Anja M., Dashti, Hesam, Stefek, Adam, McGonagle, Elizabeth, Strobel, Sophie, Laber, Samantha, Agrawal, Saaket, Westcott, Gregory P., Kar, Amrita, Veregge, Molly L., Gulko, Anton, Srinivasan, Harini, Kramer, Zachary, De Filippis, Eleanna, Merkel, Erin, Ducie, Jennifer, Boyd, Christopher G., Gourash, William, Courcoulas, Anita, Lin, Samuel J., Lee, Bernard T., Morris, Donald, Tobias, Adam, Khera, Amit V., Claussnitzer, Melina, Pers, Tune H., Giordano, Antonio, Ashenberg, Orr, Regev, Aviv, Tsai, Linus T., Rosen, Evan D.

Issue&Volume: 2022-03-16

Abstract: White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions. A single-cell atlas of white adipose tissue from mouse and human reveals diverse cell types and similarities and differences across species and dietary conditions.

DOI: 10.1038/s41586-022-04518-2

Source: https://www.nature.com/articles/s41586-022-04518-2

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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