小柯机器人

德国哥廷根大学Francesca Odoardi、Alexander Flügel等研究人员合作发现，肺部微生物调节大脑自身免疫。2022年2月23日，国际知名学术期刊《自然》在线发表了这一成果。

Author: Hosang, Leon, Canals, Roger Cugota, van der Flier, Felicia Joy, Hollensteiner, Jacqueline, Daniel, Rolf, Flgel, Alexander, Odoardi, Francesca

Issue&Volume: 2022-02-23

Abstract: Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune disease of the central nervous system1. In addition, the lung serves as a niche for the disease-inducing T cells for long-term survival and for maturation into migration-competent effector T cells2. Why the lung tissue in particular has such an important role in an autoimmune disease of the brain is not yet known. Here we detected a tight interconnection between the lung microbiota and the immune reactivity of the brain. A dysregulation in the lung microbiome significantly influenced the susceptibility of rats to developing autoimmune disease of the central nervous system. Shifting the microbiota towards lipopolysaccharide-enriched phyla by local treatment with neomycin induced a type-I-interferon-primed state in brain-resident microglial cells. Their responsiveness towards autoimmune-dominated stimulation by type II interferons was impaired, which led to decreased proinflammatory response, immune cell recruitment and clinical signs. Suppressing lipopolysaccharide-producing lung phyla with polymyxin B led to disease aggravation, whereas addition of lipopolysaccharide-enriched phyla or lipopolysaccharide recapitulated the neomycin effect. Our data demonstrate the existence of a lung–brain axis in which the pulmonary microbiome regulates the immune reactivity of the central nervous tissue and thereby influences its susceptibility to autoimmune disease development.

DOI: 10.1038/s41586-022-04427-4

Source: https://www.nature.com/articles/s41586-022-04427-4

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
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