小柯机器人

澳大利亚墨尔本大学Annette Fox团队近期取得重要研究进展，他们发现流感病毒感染史影响了对流感疫苗的抗体反应。该项研究成果于2022年2月17日在线发表在《自然—医学》杂志上。

在这里，研究人员调查了来自Ha Nam群体（越南）的成年人的流感疫苗接种情况，他们有目地选择在过去9年中甲型流感（H3N2）感染的72名和未感染的28名成人。主要结果是先前感染甲型 H3N2 流感对2016年11月接种的当地流感疫苗诱导的血凝素抑制抗体反应的影响。针对1968年至2018年期间的40种甲型H3N2流感病毒株进行了基线和接种后血清滴定。在每个时间点（基线、第 14 天和第 280 天），近期感染的参与者(34(29-40)、187(154-227)和86(72-103)的几何平均抗体滴度高于近期未感染的参与者(19(17-22)、91(64-130)和38(30-49))。

在第14天和第280天，近期感染的参与者对2014-2018菌株的平均滴度上升了6.1倍(5.0-7.4倍)和2.6倍(2.2-3.1倍)，而没有感染的参与者上升了4.8倍(3.5-6.7倍)和1.9倍(1.5-2.3倍)。在甲流易感季节中，72名近期感染的疫苗接种者，有一人感染甲流，28名近期未感染的疫苗接种者有4人感染了甲流（P = 0.021）。疫苗诱导的抗体所识别的甲流病毒范围与之前的感染株有关。这些结果表明，先前感染引起的免疫记忆的回忆增强了灭活流感疫苗的抗体反应，并对获得保护性抗体滴度至关重要。

据介绍，对连续疫苗接种的研究表明，针对过去流感病毒的免疫记忆可能会限制对含有当前毒株的疫苗的反应。但先前感染引起的免疫记忆影响很少被考虑并且难以确定，因为感染通常是潜在的。

附：英文原文

Title: Influenza virus infection history shapes antibody responses to influenza vaccination

Author: Auladell, Maria, Phuong, Hoang Vu Mai, Mai, Le Thi Quynh, Tseng, Yeu-Yang, Carolan, Louise, Wilks, Sam, Thai, Pham Quang, Price, David, Duong, Nguyen Thanh, Hang, Nguyen Le Khang, Thanh, Le Thi, Thuong, Nguyen Thi Hong, Huong, Tran Thi Kieu, Diep, Nguyen Thi Ngoc, Bich, Vu Thi Ngoc, Khvorov, Arseniy, Hensen, Luca, Duong, Tran Nhu, Kedzierska, Katherine, Anh, Dang Duc, Wertheim, Heiman, Boyd, Scott D., Good-Jacobson, Kim L., Smith, Derek, Barr, Ian, Sullivan, Sheena, van Doorn, H. Rogier, Fox, Annette

Issue&Volume: 2022-02-17

Abstract: Studies of successive vaccination suggest that immunological memory against past influenza viruses may limit responses to vaccines containing current strains. The impact of memory induced by prior infection is rarely considered and is difficult to ascertain, because infections are often subclinical. This study investigated influenza vaccination among adults from the Ha Nam cohort (Vietnam), who were purposefully selected to include 72 with and 28 without documented influenza A(H3N2) infection during the preceding 9 years (Australian New Zealand Clinical Trials Registry 12621000110886). The primary outcome was the effect of prior influenza A(H3N2) infection on hemagglutinin-inhibiting antibody responses induced by a locally available influenza vaccine administered in November 2016. Baseline and postvaccination sera were titrated against 40 influenza A(H3N2) strains spanning 1968–2018. At each time point (baseline, day 14 and day 280), geometric mean antibody titers against 2008–2018 strains were higher among participants with recent infection (34 (29–40), 187 (154–227) and 86 (72–103)) than among participants without recent infection (19 (17–22), 91 (64–130) and 38 (30–49)). On days 14 and 280, mean titer rises against 2014–2018 strains were 6.1-fold (5.0- to 7.4-fold) and 2.6-fold (2.2- to 3.1-fold) for participants with recent infection versus 4.8-fold (3.5- to 6.7-fold) and 1.9-fold (1.5- to 2.3-fold) for those without. One of 72 vaccinees with recent infection versus 4 of 28 without developed symptomatic A(H3N2) infection in the season after vaccination (P=0.021). The range of A(H3N2) viruses recognized by vaccine-induced antibodies was associated with the prior infection strain. These results suggest that recall of immunological memory induced by prior infection enhances antibody responses to inactivated influenza vaccine and is important to attain protective antibody titers.

DOI: 10.1038/s41591-022-01690-w

Source: https://www.nature.com/articles/s41591-022-01690-w

Nature Medicine：《自然—医学》，创刊于1995年。隶属于施普林格·自然出版集团，最新IF：87.241
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投稿链接：https://mts-nmed.nature.com/cgi-bin/main.plex