小柯机器人

美国布朗大学David A. Borton团队实现强迫症患者颅内电生理学与行为标志物同步的长期生态学评估。该研究于2021年12月9日在线发表于国际一流学术期刊《自然—医学》。

在植入了可记录深脑刺激（DBS）设备的强迫症患者中，研究人员将慢性腹侧纹状体局部场电位与相关的、特定疾病的行为同步在诊所和家里的非结构化活动中，以及在DBS和暴露疗法中，研究人员采集了超过1000小时的局部场电位。采集数据的症状严重程度范围很广，这使研究人员能够确定强迫症症状强度的候选神经生物标志物。这项工作证明了在日常症状波动中捕捉慢性颅内电生理的可行性和实用性，从而实现神经生物标志物的识别，这是未来开发适应性DBS治疗强迫症和其他精神疾病的前提条件。

据介绍，检测与病理行为状态有关的神经特征可以使适应性DBS成为可能，这是提高DBS对神经和精神疾病疗效的潜在策略。这种方法需要确定相关行为状态的神经生物标志物，这项任务最好在生态学上有效的环境中进行。

附：英文原文

Title: Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder

Author: Provenza, Nicole R., Sheth, Sameer A., Dastin-van Rijn, Evan M., Mathura, Raissa K., Ding, Yaohan, Vogt, Gregory S., Avendano-Ortega, Michelle, Ramakrishnan, Nithya, Peled, Noam, Gelin, Luiz Fernando Fracassi, Xing, David, Jeni, Laszlo A., Ertugrul, Itir Onal, Barrios-Anderson, Adriel, Matteson, Evan, Wiese, Andrew D., Xu, Junqian, Viswanathan, Ashwin, Harrison, Matthew T., Bijanki, Kelly R., Storch, Eric A., Cohn, Jeffrey F., Goodman, Wayne K., Borton, David A.

Issue&Volume: 2021-12-09

Abstract: Detection of neural signatures related to pathological behavioral states could enable adaptive deep brain stimulation (DBS), a potential strategy for improving efficacy of DBS for neurological and psychiatric disorders. This approach requires identifying neural biomarkers of relevant behavioral states, a task best performed in ecologically valid environments. Here, in human participants with obsessive-compulsive disorder (OCD) implanted with recording-capable DBS devices, we synchronized chronic ventral striatum local field potentials with relevant, disease-specific behaviors. We captured over 1,000h of local field potentials in the clinic and at home during unstructured activity, as well as during DBS and exposure therapy. The wide range of symptom severity over which the data were captured allowed us to identify candidate neural biomarkers of OCD symptom intensity. This work demonstrates the feasibility and utility of capturing chronic intracranial electrophysiology during daily symptom fluctuations to enable neural biomarker identification, a prerequisite for future development of adaptive DBS for OCD and other psychiatric disorders.

DOI: 10.1038/s41591-021-01550-z

Source: https://www.nature.com/articles/s41591-021-01550-z

Nature Medicine：《自然—医学》，创刊于1995年。隶属于施普林格·自然出版集团，最新IF：87.241
官方网址：https://www.nature.com/nm/
投稿链接：https://mts-nmed.nature.com/cgi-bin/main.plex