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研究揭示适应性刺激选择在海马区的巩固作用
2021-12-12 22:25

美国哥伦比亚大学Attila Losonczy研究小组揭示适应性刺激选择在海马区的巩固作用。这一研究成果于2021年12月8日在线发表在国际学术期刊《自然》上。

据研究人员介绍,联想记忆通过将预测结果的感官刺激结合在一起指导行为适应。然而,在一个特征丰富的环境中,只有一部分刺激可能会预测一个期望的结果。神经回路如何通过选择性地和持久地表征与特定结果相关的感觉刺激子集来实现行为适应,目前还不清楚。

研究人员揭示了在记忆获得和随后的巩固过程中海马区的这种特征选择过程。CA3轴突到CA1的双光子钙成像与同步的局部场电位记录相结合,发现CA3轴突编码行为上有信息的感觉刺激,在记忆回放事件中被选择性地招募,这也是海马记忆巩固的基础。这些轴突形成连续的集合,将感觉特征与空间位置联系起来,从而使奖励接近。相比之下,在记忆回放过程中,编码无信息的、游离的感觉线索的轴突被明显抑制。因此,在海马体全面编码实时感觉环境的同时,它实施了一个灵活的过滤机制,从而最大限度地提高预定长期储存记忆的效用。研究人员提出,在记忆巩固过程中对感觉经验的效用依赖性招募是联想学习的一个通用编码原则。
 
附:英文原文
 
Title: Adaptive stimulus selection for consolidation in the hippocampus

Author: Terada, Satoshi, Geiller, Tristan, Liao, Zhenrui, OHare, Justin, Vancura, Bert, Losonczy, Attila

Issue&Volume: 2021-12-08

Abstract: Associative memories guide behavioural adaptation by binding together outcome-predictive sensory stimuli1,2. However, in a feature-rich environment, only a subset of stimuli may predict a desired outcome3,4. How neural circuits enable behavioural adaptation by selectively and durably representing subsets of sensory stimuli that are pertinent to a specific outcome is not known. We investigated this feature selection process in the hippocampus during memory acquisition and subsequent consolidation. Two-photon calcium imaging of CA3 axonal projections to CA1 combined with simultaneous local field potential recordings revealed that CA3 projections that encode behaviourally informative sensory stimuli were selectively recruited during the memory replay events that underlie hippocampal memory consolidation5. These axonal projections formed sequential assemblies that conjunctively link sensory features to spatial location and thus reward proximity. By contrast, axons encoding uninformative, peripatetic sensory cues were notably suppressed during memory replay. Thus, while the hippocampus comprehensively encodes the real-time sensory environment, it implements a flexible filtering mechanism to maximize the utility of memories destined for long-term storage. We propose that utility-dependent recruitment of sensory experience during memory consolidation is a general coding principle for associative learning.

DOI: 10.1038/s41586-021-04118-6

Source: https://www.nature.com/articles/s41586-021-04118-6

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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