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弓鳍鱼基因组阐明鳍鱼发育进化进程
2021-08-31 15:14

美国密歇根州立大学Ingo Braasch课题组通过弓鳍鱼(Amia calva)基因组粉分析阐明了鳍鱼的发育进化进程。2021年8月30日出版的《自然—遗传学》杂志发表了这项成果。

他们提出了一种用于弓鳍鱼的染色体水平基因组组装,它可以进行基因顺序分析,解决长期争论不休的新翅目系统发育关系的问题。他们通过弓鳍鱼发育检查染色质可及性和基因表达,以研究免疫、规模、呼吸和鳍骨骼系统的进化,并确定数百个在脊椎动物中保守的基因调控位点。这些结果将硬骨鱼类之间的发育进化联系起来,进一步突出了弓鳍鱼在基因组时代对阐明脊椎动物生物学和多样性的重要性。

据悉,弓鳍鱼是一种鳍鱼,拥有一套独特的祖先和衍生表型,这是了解脊椎动物进化的关键。弓鳍鱼作为新翅目鱼类代表的系统发育位置、其原型身体计划及其不重复且缓慢进化的基因组,使弓鳍鱼成为鳍鱼类基因组探索的核心物种。

附:英文原文

Title: The bowfin genome illuminates the developmental evolution of ray-finned fishes

Author: Thompson, Andrew W., Hawkins, M. Brent, Parey, Elise, Wcisel, Dustin J., Ota, Tatsuya, Kawasaki, Kazuhiko, Funk, Emily, Losilla, Mauricio, Fitch, Olivia E., Pan, Qiaowei, Feron, Romain, Louis, Alexandra, Montfort, Jrme, Milhes, Marine, Racicot, Brett L., Childs, Kevin L., Fontenot, Quenton, Ferrara, Allyse, David, Solomon R., McCune, Amy R., Dornburg, Alex, Yoder, Jeffrey A., Guiguen, Yann, Roest Crollius, Hugues, Berthelot, Camille, Harris, Matthew P., Braasch, Ingo

Issue&Volume: 2021-08-30

Abstract: The bowfin (Amia calva) is a ray-finned fish that possesses a unique suite of ancestral and derived phenotypes, which are key to understanding vertebrate evolution. The phylogenetic position of bowfin as a representative of neopterygian fishes, its archetypical body plan and its unduplicated and slowly evolving genome make bowfin a central species for the genomic exploration of ray-finned fishes. Here we present a chromosome-level genome assembly for bowfin that enables gene-order analyses, settling long-debated neopterygian phylogenetic relationships. We examine chromatin accessibility and gene expression through bowfin development to investigate the evolution of immune, scale, respiratory and fin skeletal systems and identify hundreds of gene-regulatory loci conserved across vertebrates. These resources connect developmental evolution among bony fishes, further highlighting the bowfin’s importance for illuminating vertebrate biology and diversity in the genomic era.

DOI: 10.1038/s41588-021-00914-y

Source: https://www.nature.com/articles/s41588-021-00914-y

Nature Genetics:《自然—遗传学》,创刊于1992年。隶属于施普林格·自然出版集团,最新IF:41.307
官方网址:https://www.nature.com/ng/
投稿链接:https://mts-ng.nature.com/cgi-bin/main.plex


本期文章:《自然—遗传学》:Online/在线发表

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