美国纽约大学György Buzsáki、David Tingley等研究人员合作揭示海马区尖锐波-涟漪的代谢功能。相关论文于2021年8月11日在线发表在《自然》杂志上。
研究人员同时测量了海马的电生理活动和自由行为大鼠体内的间质葡萄糖浓度，从而确定了一种可能将海马的这些不同功能联系起来的活动模式。研究人员发现，从海马中记录的尖锐波-涟漪可靠地预测了周围葡萄糖浓度在大约10分钟内的下降。这种相关性不依赖于昼夜节律、超节律或膳食触发的波动，并可以用光遗传学诱导的波纹在海马（但不在顶叶皮层）中模拟，并且通过药物遗传学抑制侧隔的活动而减弱到偶然水平，侧隔是海马和下丘脑之间的主要通道。
这些研究结果表明，尖锐波-涟漪的一个功能是调节外周葡萄糖平衡，并为2型糖尿病患者的睡眠中断和血糖失调之间的联系提供了一个机制。
据介绍，海马以前被认为与认知和内分泌功能都有关系。
附：英文原文
Title: A metabolic function of the hippocampal sharp wave-ripple
Author: Tingley, David, McClain, Kathryn, Kaya, Ekin, Carpenter, Jordan, Buzski, Gyrgy
Issue&Volume: 2021-08-11
Abstract: The hippocampus has previously been implicated in both cognitive and endocrine functions1,2,3,4,5,6,7,8,9,10,11,12,13,14,15. We simultaneously measured electrophysiological activity from the hippocampus and interstitial glucose concentrations in the body of freely behaving rats to identify an activity pattern that may link these disparate functions of the hippocampus. Here we report that clusters of sharp wave-ripples recorded from the hippocampus reliably predicted a decrease in peripheral glucose concentrations within about 10 min. This correlation was not dependent on circadian, ultradian or meal-triggered fluctuations, could be mimicked with optogenetically induced ripples in the hippocampus (but not in the parietal cortex) and was attenuated to chance levels by pharmacogenetically suppressing activity of the lateral septum, which is the major conduit between the hippocampus and the hypothalamus. Our findings demonstrate that a function of the sharp wave-ripple is to modulate peripheral glucose homeostasis, and offer a mechanism for the link between sleep disruption and blood glucose dysregulation in type 2 diabetes16,17,18.
DOI: 10.1038/s41586-021-03811-w
Source: https://www.nature.com/articles/s41586-021-03811-w
Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html
本期文章：《自然》：Online/在线发表
