小柯机器人

美国西北大学John A. Rogers团队在研究中取得进展。他们研究出无线或无需电池的完全植入式和生物可吸收心脏起搏器。2021年6月28日，国际学术期刊《自然-生物技术》发表了这一成果。

研究人员研发了一种无引线、无电池、完全植入式心脏起搏器，用于术后控制心率和节律，并且在限定的操作时间内可通过自然生物过程完全溶解和清除。研究人员展示了这些设备在小鼠、大鼠、兔、犬和人类心脏模型中可为各种大小的心脏提供有效起搏，并具有特定的几何形状和操作时间尺度，其由无线能量传输提供能量支持。这种方法克服了传统临时起搏装置的主要缺点，可作为下一代术后临时起搏技术的基础。

据了解，在手术恢复期间使用的临时心脏起搏器需要跨皮肤的导线和外部硬件，这些硬件具有感染风险、限制患者活动并可能在移除导线期时损坏心脏功能。

附：英文原文

Title: Fully implantable and bioresorbable cardiac pacemakers without leads or batteries

Author: Yeon Sik Choi, Rose T. Yin, Anna Pfenniger, Jahyun Koo, Raudel Avila, K. Benjamin Lee, Sheena W. Chen, Geumbee Lee, Gang Li, Yun Qiao, Alejandro Murillo-Berlioz, Alexi Kiss, Shuling Han, Seung Min Lee, Chenhang Li, Zhaoqian Xie, Yu-Yu Chen, Amy Burrell, Beth Geist, Hyoyoung Jeong, Joohee Kim, Hong-Joon Yoon, Anthony Banks, Seung-Kyun Kang, Zheng Jenny Zhang, Chad R. Haney, Alan Varteres Sahakian, David Johnson, Tatiana Efimova, Yonggang Huang, Gregory D. Trachiotis, Bradley P. Knight, Rishi K. Arora, Igor R. Efimov, John A. Rogers

Issue&Volume: 2021-06-28

Abstract: Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology. A biodegradable pacemaker without external leads improves the safety of temporary cardiac pacing.

DOI: 10.1038/s41587-021-00948-x

Source: https://www.nature.com/articles/s41587-021-00948-x

Nature Biotechnology：《自然—生物技术》，创刊于1996年。隶属于施普林格·自然出版集团，最新IF：68.164
官方网址：https://www.nature.com/nbt/
投稿链接：https://mts-nbt.nature.com/cgi-bin/main.plex