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研究揭示肠道菌群特异性T细胞的胸腺发育历程
2021-05-16 15:20

美国斯隆•凯特琳纪念癌症中心 Gretchen E. Diehl和犹他大学医学院Matthew L. Bettini课题组合作的最新研究揭示了肠道菌群特异性T细胞的胸腺发育。2021年5月12日,国际学术期刊《自然》在线发表了这一成果。

研究人员发现肠道菌群在早期生活中会导致肠道树突状细胞将微生物抗原从肠道运输到胸腺,然后诱导微生物群特异性T细胞的扩增。一旦进入外围,微生物群特异性T细胞就具有致病性或可以抵抗相关病原体的侵害。通过这种方式,正在发育的微生物群可以塑造并扩展胸腺和外周T细胞库,从而增强了对肠道微生物和病原体的识别能力。

据了解,人与其共生微生物群已形成互惠互利的关系,其中人类宿主为微生物提供了友好的生存环境,微生物群则为宿主提供了许多好处,包括营养和免受病原体感染的保护。维持这种关系需要处理好免疫平衡,在维持共生微生物的同时限制炎症性抗共生反应。已有报道揭示T细胞对肠道微生物抗原的特异性识别。尽管局部微环境决定了效应细胞的分化,但尚不清楚在胸腺如何产生微生物群特异性T细胞。

附:英文原文

Title: Thymic development of gut-microbiota-specific T cells

Author: Daniel F. Zegarra-Ruiz, Dasom V. Kim, Kendra Norwood, Myunghoo Kim, Wan-Jung H. Wu, Fatima B. Saldana-Morales, Andrea A. Hill, Shubhabrata Majumdar, Stephanie Orozco, Rickesha Bell, June L. Round, Randy S. Longman, Takeshi Egawa, Matthew L. Bettini, Gretchen E. Diehl

Issue&Volume: 2021-05-12

Abstract: Humans and their microbiota have coevolved a mutually beneficial relationship in which the human host provides a hospitable environment for the microorganisms and the microbiota provides many advantages for the host, including nutritional benefits and protection from pathogen infection1. Maintaining this relationship requires a careful immune balance to contain commensal microorganisms within the lumen while limiting inflammatory anti-commensal responses1,2. Antigen-specific recognition of intestinal microorganisms by T cells has previously been described3,4. Although the local environment shapes the differentiation of effector cells3,4,5 it is unclear how microbiota-specific T cells are educated in the thymus. Here we show that intestinal colonization in early life leads to the trafficking of microbial antigens from the intestine to the thymus by intestinal dendritic cells, which then induce the expansion of microbiota-specific T cells. Once in the periphery, microbiota-specific T cells have pathogenic potential or can protect against related pathogens. In this way, the developing microbiota shapes and expands the thymic and peripheral T cell repertoire, allowing for enhanced recognition of intestinal microorganisms and pathogens.

DOI: 10.1038/s41586-021-03531-1

Source: https://www.nature.com/articles/s41586-021-03531-1

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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