小柯机器人

美国加州大学洛杉矶分校Timothy E. O’Sullivan研究团队揭示健康和肥胖者中白色脂肪组织的新细胞状态。这一研究成果于2021年4月27日在线发表在国际学术期刊《自然—免疫学》上。

通过使用单细胞转录组学和流式细胞仪，研究人员揭示了健康的非肥胖者和肥胖者白色脂肪组织（WAT）基质血管部分的大规模综合细胞普查。研究人员报告了肥胖者WAT中积累的脂肪驻留先天性淋巴样细胞、树突状细胞和单核细胞衍生的巨噬细胞群体的新亚群和发展轨迹。对细胞-细胞配体-受体相互作用和肥胖症富集的信号通路分析揭示了从肥胖WAT中的免疫调节机制向肥胖WAT中的炎症网络的转变。这些结果提供了健康人群WAT中稳态和炎症回路的详细且无偏倚的细胞图谱。

据悉，白色脂肪组织（WAT）是能量储存和全身代谢稳态的重要调节剂。 由免疫细胞和结构细胞组成的调控网络对于维持WAT代谢是必不可少的，WAT代谢在哺乳动物的肥胖过程中可能会受到损害。

附：英文原文

Title: Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

Author: Andrew D. Hildreth, Feiyang Ma, Yung Yu Wong, Ryan Sun, Matteo Pellegrini, Timothy E. OSullivan

Issue&Volume: 2021-04-27

Abstract: White adipose tissue (WAT) is an essential regulator of energy storage and systemic metabolic homeostasis. Regulatory networks consisting of immune and structural cells are necessary to maintain WAT metabolism, which can become impaired during obesity in mammals. Using single-cell transcriptomics and flow cytometry, we unveil a large-scale comprehensive cellular census of the stromal vascular fraction of healthy lean and obese human WAT. We report new subsets and developmental trajectories of adipose-resident innate lymphoid cells, dendritic cells and monocyte-derived macrophage populations that accumulate in obese WAT. Analysis of cell–cell ligand–receptor interactions and obesity-enriched signaling pathways revealed a switch from immunoregulatory mechanisms in lean WAT to inflammatory networks in obese WAT. These results provide a detailed and unbiased cellular landscape of homeostatic and inflammatory circuits in healthy human WAT.

DOI: 10.1038/s41590-021-00922-4

Source: https://www.nature.com/articles/s41590-021-00922-4

Nature Biotechnology：《自然—生物技术》，创刊于1996年。隶属于施普林格·自然出版集团，最新IF：68.164
官方网址：https://www.nature.com/nbt/
投稿链接：https://mts-nbt.nature.com/cgi-bin/main.plex