小柯机器人

加拿大多伦多大学附属儿童医院Paul W. Frankland团队研究发现，抑制性海马-丘脑通路调节久远记忆检索。 2021年3月29日，国际学术期刊《自然-神经科学》发表了这一成果。

在小鼠中，研究人员发现一个与记忆检索有关大脑区域（丘脑前核）的主动脱离对于较远时间点记忆召回是必要的，此外，丘脑前核投射介导了这种抑制作用。具体来说，研究人员确定了从CA3到丘脑前核的稀疏抑制投射，该投射在系统整合过程中变得更加活跃，因此，有必要在恐惧记忆形成后的较远而非最近的时间点回忆该记忆。

据介绍，分散的海马-丘脑-皮层网络对于记忆维持至关重要，但是有利于网络活动的大脑区域可能会随着记忆年龄的变化而变化。重组的过程称为系统合并，先前的研究已经探究了不同海马、丘脑和皮层大脑区域的激活与召回时记忆年龄之间的关系。虽然某些大脑区域的激活会随着记忆年龄的增长而增加，但其他区域的活跃度却下降。

附：英文原文

Title: An inhibitory hippocampal–thalamic pathway modulates remote memory retrieval

Author: Gisella Vetere, Frances Xia, Adam I. Ramsaran, Lina M. Tran, Sheena A. Josselyn, Paul W. Frankland

Issue&Volume: 2021-03-29

Abstract: Memories are supported by distributed hippocampal–thalamic–cortical networks, but the brain regions that contribute to network activity may vary with memory age. This process of reorganization is referred to as systems consolidation, and previous studies have examined the relationship between the activation of different hippocampal, thalamic, and cortical brain regions and memory age at the time of recall. While the activation of some brain regions increases with memory age, other regions become less active. In mice, here we show that the active disengagement of one such brain region, the anterodorsal thalamic nucleus, is necessary for recall at remote time-points and, in addition, which projection(s) mediate such inhibition. Specifically, we identified a sparse inhibitory projection from CA3 to the anterodorsal thalamic nucleus that becomes more active during systems consolidation, such that it is necessary for contextual fear memory retrieval at remote, but not recent, time-points post-learning.

DOI: 10.1038/s41593-021-00819-3

Source: https://www.nature.com/articles/s41593-021-00819-3

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex