美国国立卫生研究院Masaru Kanekiyo、Barney S. Graham和华盛顿大学Neil P. King课题组合作发现，四价流感纳米颗粒疫苗具有广泛的保护作用。这一研究成果发表在2021年3月24日出版的国际学术期刊《自然》杂志上。
他们显示了经过计算设计的两组分纳米颗粒免疫原，可以有效地针对多种流感病毒进行中和和保护性抗体反应。纳米粒子免疫原是包含20个血凝素糖蛋白三聚体有序阵列，并且它们的体外组装能够以限定的比率精确控制共同展示多种不同的血凝素蛋白。
共同展示许可的四价流感疫苗的四种血凝素的纳米粒子免疫原，在几种动物模型中引起了与疫苗匹配株等同或优于市售四价流感疫苗的抗体反应，并同时通过靶向主要但保守的血凝素茎，诱导了对异源病毒的广泛保护性抗体反应。纳米粒子免疫原诱导的强大受体阻断和交叉反应性茎定向抗体相结合，使其成为季节性超流感疫苗的诱人候选物，有可能替代常规季节性疫苗。
据了解，为各种病毒株提供广泛而持久的保护的流感疫苗将对全球健康产生重大影响，因为它们将减少每年重新配制和免疫疫苗的需求。
附：英文原文
Title: Quadrivalent influenza nanoparticle vaccines induce broad protection
Author: Seyhan Boyoglu-Barnum, Daniel Ellis, Rebecca A. Gillespie, Geoffrey B. Hutchinson, Young-Jun Park, Syed M. Moin, Oliver J. Acton, Rashmi Ravichandran, Mike Murphy, Deleah Pettie, Nick Matheson, Lauren Carter, Adrian Creanga, Michael J. Watson, Sally Kephart, Sila Ataca, John R. Vaile, George Ueda, Michelle C. Crank, Lance Stewart, Kelly K. Lee, Miklos Guttman, David Baker, John R. Mascola, David Veesler, Barney S. Graham, Neil P. King, Masaru Kanekiyo
Issue&Volume: 2021-03-24
Abstract: Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and immunization1. Here we show that computationally designed, two-component nanoparticle immunogens2 induce potently neutralizing and broadly protective antibody responses against a wide variety of influenza viruses. The nanoparticle immunogens contain 20 haemagglutinin glycoprotein trimers in an ordered array, and their assembly in vitro enables the precisely controlled co-display of multiple distinct haemagglutinin proteins in defined ratios. Nanoparticle immunogens that co-display the four haemagglutinins of licensed quadrivalent influenza vaccines elicited antibody responses in several animal models against vaccine-matched strains that were equivalent to or better than commercial quadrivalent influenza vaccines, and simultaneously induced broadly protective antibody responses to heterologous viruses by targeting the subdominant yet conserved haemagglutinin stem. The combination of potent receptor-blocking and cross-reactive stem-directed antibodies induced by the nanoparticle immunogens makes them attractive candidates for a supraseasonal influenza vaccine candidate with the potential to replace conventional seasonal vaccines3. A nanoparticle influenza vaccine candidate is shown to induce broad cross-reactive antibody responses in animal models.
DOI: 10.1038/s41586-021-03365-x
Source: https://www.nature.com/articles/s41586-021-03365-x
Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html
本期文章：《自然》：Online/在线发表
