美国洛克菲勒大学Paul Cohen小组的研究表明棕色脂肪组织（BAT）与心脏代谢健康有关。2021年1月4日出版的《自然-医学》发表了这项成果。
研究人员根据有无BAT，对52487名患者的134529例18F-氟脱氧葡萄糖正电子发射计算机断层扫描术-计算机断层扫描进行了归类，并使用倾向评分匹配来组建研究队列。对研究人群进行扫描的最初目的是寻找与癌症诊断、治疗或监测有关的指标，并没有进行其它刺激。研究发现具有BAT个体心血管疾病的患病率较低，而BAT的存在与2型糖尿病、血脂异常、冠状动脉疾病、脑血管疾病、充血性心力衰竭和高血压的低发病率无关。
这些发现为改善血糖、甘油三酸酯和高密度脂蛋白提供了依据。BAT对超重或肥胖个体的益处更为明显，这表明BAT可能在减轻肥胖弊端中发挥作用。综上所述，该研究揭示了BAT在促进心脏代谢健康中的潜在作用。
研究人员表示，白色脂肪储存多余的能量，而棕色和米色脂肪具有产热功能，通过消耗能量来产热。尽管尚不清楚BAT影响人类代谢和心血管疾病的程度，但在小鼠模型中产热脂肪组织显著改善了葡萄糖和脂质的体稳态。
附：英文原文
Title: Brown adipose tissue is associated with cardiometabolic health
Author: Tobias Becher, Srikanth Palanisamy, Daniel J. Kramer, Mahmoud Eljalby, Sarah J. Marx, Andreas G. Wibmer, Scott D. Butler, Caroline S. Jiang, Roger Vaughan, Heiko Schder, Allyn Mark, Paul Cohen
Issue&Volume: 2021-01-04
Abstract: White fat stores excess energy, whereas brown and beige fat are thermogenic and dissipate energy as heat. Thermogenic adipose tissues markedly improve glucose and lipid homeostasis in mouse models, although the extent to which brown adipose tissue (BAT) influences metabolic and cardiovascular disease in humans is unclear1,2. Here we retrospectively categorized 134,529 18F-fluorodeoxyglucose positron emission tomography–computed tomography scans from 52,487 patients, by presence or absence of BAT, and used propensity score matching to assemble a study cohort. Scans in the study population were initially conducted for indications related to cancer diagnosis, treatment or surveillance, without previous stimulation. We report that individuals with BAT had lower prevalences of cardiometabolic diseases, and the presence of BAT was independently correlated with lower odds of type 2 diabetes, dyslipidemia, coronary artery disease, cerebrovascular disease, congestive heart failure and hypertension. These findings were supported by improved blood glucose, triglyceride and high-density lipoprotein values. The beneficial effects of BAT were more pronounced in individuals with overweight or obesity, indicating that BAT might play a role in mitigating the deleterious effects of obesity. Taken together, our findings highlight a potential role for BAT in promoting cardiometabolic health.
DOI: 10.1038/s41591-020-1126-7
Source: https://www.nature.com/articles/s41591-020-1126-7
Nature Medicine：《自然—医学》，创刊于1995年。隶属于施普林格·自然出版集团，最新IF：87.241
官方网址：https://www.nature.com/nm/
投稿链接：https://mts-nmed.nature.com/cgi-bin/main.plex
本期文章：《自然—医学》：Online/在线发表
