小柯机器人

韩国基础科学研究所Choong-Wan Woo、美国达特茅斯学院Tor D. Wager等研究人员合作发现一个可用于鉴定持续实验和临床疼痛的神经影像生物标志物。该项研究成果于2021年1月4日在线发表在《自然—医学》杂志上。

研究人员开发了基于全脑功能连通性的功能磁共振成像特征，该特征跟踪了实验诱发的持续性疼痛强度，并在六项研究中测试了其对临床疼痛的敏感性、特异性和通用性（总计n=334）。在三项有关口面部持续性疼痛和厌恶的独立研究中，该特征显示出对持续性疼痛的高度敏感性和特异性。它还在两项针对临床下背痛的独立研究中预测了临床疼痛的严重程度，并对患者和对照组进行了分类。持续性和临床疼痛表现出相似的网络水平表征，尤其是在躯体运动、额叶额叶和背部注意网络中。这些模式与实验性痛的表现形式不同。

这项研究确定了持续性疼痛的脑生物标志物，并具有高度的临床转换潜力。

据了解，持续的疼痛是临床疼痛疾病的主要特征，但是很难与患者同时出现的认知和情绪特征分开评估。

附：英文原文

Title: A neuroimaging biomarker for sustained experimental and clinical pain

Author: Jae-Joong Lee, Hong Ji Kim, Marta eko, Bo-yong Park, Soo Ahn Lee, Hyunjin Park, Mathieu Roy, Seong-Gi Kim, Tor D. Wager, Choong-Wan Woo

Issue&Volume: 2021-01-04

Abstract: Sustained pain is a major characteristic of clinical pain disorders, but it is difficult to assess in isolation from co-occurring cognitive and emotional features in patients. In this study, we developed a functional magnetic resonance imaging signature based on whole-brain functional connectivity that tracks experimentally induced tonic pain intensity and tested its sensitivity, specificity and generalizability to clinical pain across six studies (total n = 334). The signature displayed high sensitivity and specificity to tonic pain across three independent studies of orofacial tonic pain and aversive taste. It also predicted clinical pain severity and classified patients versus controls in two independent studies of clinical low back pain. Tonic and clinical pain showed similar network-level representations, particularly in somatomotor, frontoparietal and dorsal attention networks. These patterns were distinct from representations of experimental phasic pain. This study identified a brain biomarker for sustained pain with high potential for clinical translation. The functional magnetic resonance imaging connectivity pattern of tonic experimental orofacial pain can be used as a quantitative and unbiased biomarker of clinical pain.

DOI: 10.1038/s41591-020-1142-7

Source: https://www.nature.com/articles/s41591-020-1142-7

Nature Medicine：《自然—医学》，创刊于1995年。隶属于施普林格·自然出版集团，最新IF：87.241
官方网址：https://www.nature.com/nm/
投稿链接：https://mts-nmed.nature.com/cgi-bin/main.plex