美国西北大学Guillermo Oliver研究小组发现，淋巴管分泌信号可促进心脏生长和修复。相关论文于2020年12月9日在线发表在《自然》杂志上。
研究人员发现，淋巴管可以促进小鼠的心脏生长、修复和心脏保护。结果表明，由淋巴管内皮细胞（LEC）产生的淋巴管分泌信号控制心脏发育过程中心肌细胞的增殖和存活，改善新生儿心脏再生，并在心肌梗塞后具有心脏保护作用。缺乏LEC的胚胎会因心肌细胞增殖减少和心肌细胞凋亡增加而导致心脏变小。在LEC条件培养基中培养原代小鼠心肌细胞可增加心肌细胞的增殖和存活，这表明LEC产生控制心肌细胞稳态的淋巴血管分泌信号。LEC分泌基因组的鉴定表明细胞外蛋白reelin（RELN）是该过程的关键组成部分。
此外，研究人员发现，LEC特异性的Reln-null小鼠胚胎发育的心脏较小，RELN是新生儿心肌梗死后有效心脏修复和功能所必需的，并且使用胶原蛋白补丁对RELN进行心脏递送可改善成年小鼠的心肌功能通过心脏保护作用。这些结果突出了LEC在心脏发育和损伤反应中的淋巴血管分泌作用，并确定RELN是该功能的重要介导因子。
据了解，最近的研究表明，淋巴管系统有助于心脏受伤后恢复心脏功能。
附：英文原文
Title: Lymphoangiocrine signals promote cardiac growth and repair
Author: Xiaolei Liu, Ester De la Cruz, Xiaowu Gu, Laszlo Balint, Michael Oxendine-Burns, Tamara Terrones, Wanshu Ma, Hui-Hsuan Kuo, Connor Lantz, Trisha Bansal, Edward Thorp, Paul Burridge, Zoltn Jakus, Joachim Herz, Ondine Cleaver, Miguel Torres, Guillermo Oliver
Issue&Volume: 2020-12-09
Abstract: Recent studies have suggested that lymphatics help to restore heart function after cardiac injury1,2,3,4,5,6. Here we report that lymphatics promote cardiac growth, repair and cardioprotection in mice. We show that a lymphoangiocrine signal produced by lymphatic endothelial cells (LECs) controls the proliferation and survival of cardiomyocytes during heart development, improves neonatal cardiac regeneration and is cardioprotective after myocardial infarction. Embryos that lack LECs develop smaller hearts as a consequence of reduced cardiomyocyte proliferation and increased cardiomyocyte apoptosis. Culturing primary mouse cardiomyocytes in LEC-conditioned medium increases cardiomyocyte proliferation and survival, which indicates that LECs produce lymphoangiocrine signals that control cardiomyocyte homeostasis. Characterization of the LEC secretome identified the extracellular protein reelin (RELN) as a key component of this process. Moreover, we report that LEC-specific Reln-null mouse embryos develop smaller hearts, that RELN is required for efficient heart repair and function after neonatal myocardial infarction, and that cardiac delivery of RELN using collagen patches improves heart function in adult mice after myocardial infarction by a cardioprotective effect. These results highlight a lymphoangiocrine role of LECs during cardiac development and injury response, and identify RELN as an important mediator of this function.
DOI: 10.1038/s41586-020-2998-x
Source: https://www.nature.com/articles/s41586-020-2998-x
Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html
本期文章：《自然》：Online/在线发表
