小柯机器人

新加坡分子与细胞生物学研究所Nicolas Plachta课题组发现，角蛋白是哺乳动物胚胎中不对称遗传的命运决定因素。相关论文于2020年8月26日在线发表在《自然》杂志上。

Title: Keratins are asymmetrically inherited fate determinants in the mammalian embryo

Author: Hui Yi Grace Lim, Yanina D. Alvarez, Maxime Gasnier, Yiming Wang, Piotr Tetlak, Stephanie Bissiere, Hongmei Wang, Mat Biro, Nicolas Plachta

Issue&Volume: 2020-08-26

Abstract: To implant in the uterus, the mammalian embryo first specifies two cell lineages: the pluripotent inner cell mass that forms the fetus, and the outer trophectoderm layer that forms the placenta1. In many organisms, asymmetrically inherited fate determinants drive lineage specification2, but this is not thought to be the case during early mammalian development. Here we show that intermediate filaments assembled by keratins function as asymmetrically inherited fate determinants in the mammalian embryo. Unlike F-actin or microtubules, keratins are the first major components of the cytoskeleton that display prominent cell-to-cell variability, triggered by heterogeneities in the BAF chromatin-remodelling complex. Live-embryo imaging shows that keratins become asymmetrically inherited by outer daughter cells during cell division, where they stabilize the cortex to promote apical polarization and YAP-dependent expression of CDX2, thereby specifying the first trophectoderm cells of the embryo. Together, our data reveal a mechanism by which cell-to-cell heterogeneities that appear before the segregation of the trophectoderm and the inner cell mass influence lineage fate, via differential keratin regulation, and identify an early function for intermediate filaments in development. Keratins are determinants of cell fate during mammalian embryogenesis, and are distributed asymmetrically between daughter cells during cell division.

DOI: 10.1038/s41586-020-2647-4

Source: https://www.nature.com/articles/s41586-020-2647-4

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html