小柯机器人

欧洲生物信息学研究所(EMBLEBI)Robert D. Finn课题组为人类肠道微生物群的204938个参考基因组建立了的一个统一目录。 该项研究成果发表在2020年7月20日出版的《自然—生物技术》上。

研究团队提供了统一人类胃肠道基因组(UHGG)合集，包含4644种肠道原核生物中的204938 个非冗余基因组。这些基因组编码了超过1.7亿的蛋白序列，研究人员也将这些蛋白序列收集到统一人类胃肠道基因组（UHGP）目录中。

超过70%的UHGG物种缺乏可培养的代表，40%的UHGP缺乏功能注释。种内的基因组变异分析显示大量的附属基因和单核苷酸变异，其中许多属于特定单个人类。UHGG和UHGP合集有助于研究人类肠道微生物组中基因型与表型的联系。超过200000的肠道原核生物的参考基因组及其编码的蛋白质都被收录整理，为微生物研究者提供全面资源。

研究人员表示，全面、高质量的参考基因组对于人类肠道微生物群的功能表征和分类学是必须的。

附：英文原文

Title: A unified catalog of 204,938 reference genomes from the human gut microbiome

Author: Alexandre Almeida, Stephen Nayfach, Miguel Boland, Francesco Strozzi, Martin Beracochea, Zhou Jason Shi, Katherine S. Pollard, Ekaterina Sakharova, Donovan H. Parks, Philip Hugenholtz, Nicola Segata, Nikos C. Kyrpides, Robert D. Finn

Issue&Volume: 2020-07-20

Abstract: Comprehensive, high-quality reference genomes are required for functional characterization and taxonomic assignment of the human gut microbiota. We present the Unified Human Gastrointestinal Genome (UHGG) collection, comprising 204,938 nonredundant genomes from 4,644 gut prokaryotes. These genomes encode >170 million protein sequences, which we collated in the Unified Human Gastrointestinal Protein (UHGP) catalog. The UHGP more than doubles the number of gut proteins in comparison to those present in the Integrated Gene Catalog. More than 70% of the UHGG species lack cultured representatives, and 40% of the UHGP lack functional annotations. Intraspecies genomic variation analyses revealed a large reservoir of accessory genes and single-nucleotide variants, many of which are specific to individual human populations. The UHGG and UHGP collections will enable studies linking genotypes to phenotypes in the human gut microbiome. More than 200,000 gut prokaryotic reference genomes and the proteins they encode are collated, providing comprehensive resources for microbiome researchers.

DOI: 10.1038/s41587-020-0603-3

Source: https://www.nature.com/articles/s41587-020-0603-3

Nature Biotechnology：《自然—生物技术》，创刊于1996年。隶属于施普林格·自然出版集团，最新IF：68.164
官方网址：https://www.nature.com/nbt/
投稿链接：https://mts-nbt.nature.com/cgi-bin/main.plex