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研究揭示癌症患者中COVID-19疾病严重程度的决定因素
2020-06-28 11:55
来源：小柯机器人

美国纪念斯隆·凯特琳癌症中心Mini Kamboj等研究人员发现癌症患者中COVID-19疾病严重程度的决定因素。该项研究成果于2020年6月24日在线发表在《自然—医学》杂志上。

从2020年3月10日至4月7日，研究人员在纪念斯隆·凯特琳癌症中心诊断出423例有症状的COVID-19病例（总共2,035名接受癌症检查的患者）。其中40％因COVID-19住院，20％患有严重的呼吸系统疾病（包括9％的需要机械通气），12％的患者在30天内死亡。年龄大于65岁和接受免疫检查点抑制剂（ICI）治疗是住院和严重疾病的预测因素，而接受化学疗法和大手术则不是。总体而言，患有癌症的COVID-19患者存在更高的住院率高和严重后果。在这项研究中，ICI与COVID-19结局之间观察到的相关性将需要在肿瘤特异性队列中进一步研究。
 
据悉，截至2020年4月10日，纽约州共有180,458例严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）病例，并报告了9,385例死亡。癌症患者占死者的8.4％。来自中国和意大利的人群研究表明，癌症患者中冠状病毒病2019（COVID-19）的死亡率更高，尽管尚不清楚哪些方面会增加严重COVID-19的风险。这些信息对于权衡是减少SARS-CoV-2暴露还是持续癌症治疗很关键。
 
附：英文原文

Title: Determinants of COVID-19 disease severity in patients with cancer

Author: Elizabeth V. Robilotti, N. Esther Babady, Peter A. Mead, Thierry Rolling, Rocio Perez-Johnston, Marilia Bernardes, Yael Bogler, Mario Caldararo, Cesar J. Figueroa, Michael S. Glickman, Alexa Joanow, Anna Kaltsas, Yeon Joo Lee, Anabella Lucca, Amanda Mariano, Sejal Morjaria, Tamara Nawar, Genovefa A. Papanicolaou, Jacqueline Predmore, Gil Redelman-Sidi, Elizabeth Schmidt, Susan K. Seo, Kent Sepkowitz, Monika K. Shah, Jedd D. Wolchok, Tobias M. Hohl, Ying Taur, Mini Kamboj

Issue&Volume: 2020-06-24

Abstract: As of 10 April 2020, New York State had 180,458 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 9,385 reported deaths. Patients with cancer comprised 8.4% of deceased individuals1. Population-based studies from China and Italy suggested a higher coronavirus disease 2019 (COVID-19) death rate in patients with cancer2,3, although there is a knowledge gap as to which aspects of cancer and its treatment confer risk of severe COVID-194. This information is critical to balance the competing safety considerations of reducing SARS-CoV-2 exposure and cancer treatment continuation. From 10 March to 7 April 2020, 423 cases of symptomatic COVID-19 were diagnosed at Memorial Sloan Kettering Cancer Center (from a total of 2,035 patients with cancer tested). Of these, 40% were hospitalized for COVID-19, 20% developed severe respiratory illness (including 9% who required mechanical ventilation) and 12% died within 30 d. Age older than 65 years and treatment with immune checkpoint inhibitors (ICIs) were predictors for hospitalization and severe disease, whereas receipt of chemotherapy and major surgery were not. Overall, COVID-19 in patients with cancer is marked by substantial rates of hospitalization and severe outcomes. The association observed between ICI and COVID-19 outcomes in our study will need further interrogation in tumor-specific cohorts. Analysis of a large, single-center cohort of patients with cancer who were infected with COVID-19 uncovers factors associated with disease severity and interactions with anti-cancer therapies

DOI: 10.1038/s41591-020-0979-0

Source: https://www.nature.com/articles/s41591-020-0979-0

Nature Medicine：《自然—医学》，创刊于1995年。隶属于施普林格·自然出版集团，最新IF：87.241
官方网址：https://www.nature.com/nm/
投稿链接：https://mts-nmed.nature.com/cgi-bin/main.plex


本期文章：《自然—医学》：Online/在线发表

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