小柯机器人

德国神经退行性疾病中心Martin Fuhrmann、Stefanie Poll等研究人员合作发现，记忆痕迹干扰能够削弱阿尔茨海默氏病（AD）小鼠模型的记忆唤起。2020年6月8日，《自然—神经科学》在线发表了这一成果。

Title: Memory trace interference impairs recall in a mouse model of Alzheimer’s disease

Author: Stefanie Poll, Manuel Mittag, Fabrizio Musacchio, Lena C. Justus, Eleonora Ambrad Giovannetti, Julia Steffen, Jens Wagner, Lioba Zohren, Susanne Schoch, Boris Schmidt, Walker S. Jackson, Dan Ehninger, Martin Fuhrmann

Issue&Volume: 2020-06-08

Abstract: In Alzheimer’s disease (AD), hippocampus-dependent memories underlie an extensive decline. The neuronal ensemble encoding a memory, termed engram, is partially recapitulated during memory recall. Artificial activation of an engram can restore memory in a mouse model of early AD, but its fate and the factors that render the engram nonfunctional are yet to be revealed. Here, we used repeated two-photon in vivo imaging to analyze fosGFP transgenic mice (which express enhanced GFP under the Fos promoter) performing a hippocampus-dependent memory task. We found that partial reactivation of the CA1 engram during recall is preserved under AD-like conditions. However, we identified a novelty-like ensemble that interfered with the engram and thus compromised recall. Mimicking a novelty-like ensemble in healthy mice was sufficient to affect memory recall. In turn, reducing the novelty-like signal rescued the recall impairment under AD-like conditions. These findings suggest a novel mechanistic process that contributes to the deterioration of memories in AD.

DOI: 10.1038/s41593-020-0652-4

Source: https://www.nature.com/articles/s41593-020-0652-4

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex