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石正丽团队最新研究表明新冠状病毒的源头可能是蝙蝠
2020-02-12 12:58

中国科学院武汉病毒研究所石正丽研究组近日取得一项新成果。他们推测新冠状病毒的源头可能是蝙蝠。该项研究成果在线发表在2020年2月3日的《自然》上。

研究人员对一种新型冠状病毒(2019-nCoV)进行了鉴定和表征,该冠状病毒在中国武汉市造成了流行型人类急性呼吸道综合症。该流行病始于2019年12月12日,截至2020年1月26日,已造成2,050例确诊病例,其中56例死亡。在暴发初期,研究人员从5名患者获得了该病毒的全基因组序列。它们彼此的序列几乎相同,并且与SARS-CoV有79.5%的序列相似性。

此外,研究人员还发现2019-nCoV在全基因组水平上与蝙蝠冠状病毒具有96%的相似性。对七个保守的非结构蛋白进行的成对蛋白序列分析表明,该病毒属于SARSr-CoV种。同样的,从危重病人的支气管肺泡灌洗液中也分离出2019-nCoV病毒,该病毒可以被其他几名患者的血清中和。重要的是,研究人员已经确定,这种新型CoV与SARS-CoV一样都是利用ACE2受体侵入宿主。

据悉,自18年前SARS爆发以来,研究人员发现与许多严重急性呼吸综合症相关的冠状病毒(SARSr-CoV)其天然宿主是蝙蝠。先前的研究表明,蝙蝠体内的一些SARSr-CoV可能会感染人类。

附:英文原文

Title: A pneumonia outbreak associated with a new coronavirus of probable bat origin

Author: Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Lin-Lin Liu, Bing Yan, Fa-Xian Zhan, Yan-Yi Wang, Geng-Fu Xiao, Zheng-Li Shi

Issue&Volume: 2020-02-03

Abstract: Since the SARS outbreak 18 years ago, a large number of severe acute respiratory syndrome-related coronaviruses (SARSr-CoV) have been discovered in their natural reservoir host, bats1–4. Previous studies indicated that some of those bat SARSr-CoVs have the potential to infect humans5–7. Here we report the identification and characterization of a novel coronavirus (2019-nCoV) which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started from 12 December 2019, has caused 2,050 laboratory-confirmed infections with 56 fatal cases by 26 January 2020. Full-length genome sequences were obtained from five patients at the early stage of the outbreak. They are almost identical to each other and share 79.5% sequence identify to SARS-CoV. Furthermore, it was found that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. The pairwise protein sequence analysis of seven conserved non-structural proteins show that this virus belongs to the species of SARSr-CoV. The 2019-nCoV virus was then isolated from the bronchoalveolar lavage fluid of a critically ill patient, which can be neutralized by sera from several patients. Importantly, we have confirmed that this novel CoV uses the same cell entry receptor, ACE2, as SARS-CoV.

DOI: 10.1038/s41586-020-2012-7

Source: https://www.nature.com/articles/s41586-020-2012-7

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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