小柯机器人

荷兰鹿特丹伊拉斯姆斯大学M. Kamran Ikram和Silvan Licher等研究人员合作报道了一般人群中痴呆症的遗传易感性、可改变风险因素和长期风险。该项研究成果8月26日在线发表在《自然—医学》上。

研究人员利用来自鹿特丹人口研究中的6352名55岁及以上人群的遗传和可改变风险因素的长期数据。在这项研究中，研究人员发现，在低遗传风险和中等遗传风险的个体中，与不利的情况相比，有利的可改变风险情况与较低的痴呆风险有关。相反，在具有高遗传风险的人中未发现这些保护性关联。

研究人员表示，痴呆症的确切病因尚不清楚，但遗传和生活方式因素被认为是这种复杂疾病的关键驱动因素。对家族性痴呆模式的认识发现了在痴呆的发病机制中起作用的遗传因素，包括载脂蛋白E（APOE）基因型和大量且仍在增加的遗传变异体。除遗传结构外，还有一些可改变的风险因素与痴呆症的发展有关。停止或延迟认知衰退的预防性试验正在越来越多地招募遗传易患痴呆症的老年人。然而，目前尚不清楚有针对性的健康和生活方式干预措施是否可以减弱甚至抵消增加的遗传风险。

附：英文原文

Title: Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population

Author: Silvan Licher, Shahzad Ahmad, Hata Karamuji-omi, Trudy Voortman, Maarten J. G. Leening, M. Arfan Ikram, M. Kamran Ikram

Issue&Volume: 2019-08-26

Abstract: The exact etiology of dementia is still unclear, but both genetic and lifestyle factors are thought to be key drivers of this complex disease. The recognition of familial patterns of dementia has led to the discovery of genetic factors that have a role in the pathogenesis of dementia, including the apolipoprotein E (APOE) genotype and a large and still-growing number of genetic variants1,2. Beyond genetic architecture, several modifiable risk factors have been implicated in the development of dementia3. Prevention trials of measures to halt or delay cognitive decline are increasingly recruiting older individuals who are genetically predisposed to dementia. However, it remains unclear whether targeted health and lifestyle interventions can attenuate or even offset increased genetic risk. Here, we leverage long-term data on both genetic and modifiable risk factors from 6,352 individuals aged 55 years and older in the population-based Rotterdam Study. In this study, we demonstrate that, in individuals at low and intermediate genetic risk, favorable modifiable-risk profiles are related to a lower risk of dementia compared to unfavorable profiles. In contrast, these protective associations were not found in those at high genetic risk.

DOI: 10.1038/s41591-019-0547-7

Source: https://www.nature.com/articles/s41591-019-0547-7

Nature Medicine：《自然—医学》，创刊于1995年。隶属于施普林格·自然出版集团，最新IF：87.241
官方网址：https://www.nature.com/nm/
投稿链接：https://mts-nmed.nature.com/cgi-bin/main.plex