小柯机器人

Aaron W. James课题组近日取得一项新成果。经过不懈努力，他们报道了绘制骨骼体感传入神经回路图，识别骨折愈合所需的神经生长因子信号。这一研究成果于2026年1月8日发表在国际顶尖学术期刊《科学》上。

为了表征介导骨骼痛觉和再生的神经解剖学回路，该研究组分析了骨折前后支配小鼠骨骼的背根神经节（DRG）神经元。CGRP⁺和A β-场LTMR神经元是最具代表性的骨神经支配神经元。感觉神经元对损伤反应的动态变化反映了骨修复的阶段性，包括Tgfb1、Fgf9和Shh等形态因子的表达。神经支配丧失导致骨修复不良，并与间充质细胞增殖和骨分化缺陷有关。最后，该团队确定成纤维细胞生长因子9 （FGF9）是骨折修复的主要调节因子，可以用来促进骨修复。

研究人员表示，与骨折相关的疼痛是由体感神经元介导的，这似乎也是启动骨再生所必需的。

附：英文原文

Title: Mapping somatosensory afferent circuitry to bone identifies neurotrophic signals required for fracture healing

Author: Mingxin Xu, Zhao Li, Neelima Thottappillil, Masnsen Cherief, Manyu Zhu, Xin Xing, Mario Gomez-Salazar, Chunbao Rao, Sowmya Ramesh, Juliet M. Mwirigi, Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Chi Zhang, Xue-Wei Wang, Mary Archer, Yun Guan, Robert J. Tower, Patrick Cahan, Theodore J. Price, Thomas L. Clemens, Aaron W. James

Issue&Volume: 2026-01-08

Abstract: The pain associated with bone fracture is mediated by somatosensory neurons, which also appear to be required to initiate bone regeneration. To characterize neuroanatomical circuitry mediating skeletal nociception and regeneration, we profiled dorsal root ganglia (DRG) neurons innervating murine bones using single-cell transcriptomics before and after fracture. CGRP+ and Aβ-Field LTMR neurons were the most represented classes of bone-innervating neurons. Dynamic changes in sensory neuron response to injury reflected the phasic nature of bone repair, including expression of morphogens such as Tgfb1, Fgf9, and Shh. Innervation loss resulted in poor bone repair and was associated with defective mesenchymal cell proliferation and osteodifferentiation. Finally, we identified fibroblast growth factor 9 (FGF9) as a major regulator of fracture repair that could be leveraged to promote bone repair.

DOI: adr9608

Source: https://www.science.org/doi/10.1126/science.adr9608