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付福友
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刘老师，您说的这个共线基因概念的汉语意思应该欠准确吧。简单一点讲：连锁基因是在一个染色体上的表现出遗传连锁的基因，共线基因应该是位于两个具有保守区域的区段内的基因，可能是一个染色体也可以是两个染色体，甚至多个染色体上的区段。也就是说：共线基因是位于遗传保守性区域的基因。
2017-05-21 21:35
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刘进平
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不过是这个概念确实易混淆。如：
http://schaechter.asmblog.org/schaechter/2008/12/of-terms-in-biology-synteny.html
Geneticists are known for having developed a language of their own. So is just about everybody else in science. Ergo, looking up definitions is often a necessity. Today’s term is synteny (which etymologically means “on the same ribbon”). You might think that we don't need worry about this so much in bacteria and archaea, the majority of whom have a single chromosome. All their genes are syntenic by definition. Synteny applies to multichromosomal organisms—of which there is a sizeable number within the bacteria, e.g., Rhodobacter spheroides (where this was first observed), Burkholderia cepacia, and some vibrios, brucellas, leptospiras, and rhizobia. Anyhow, we went ahead and looked up synteny. We were hoping for some enlightenment to share with you. Were we successful? Here are the results.
The occurrence of two or more loci on the same chromosome, without regard to the distance between them. Source
Portions of chromosomes in which gene order is conserved. Source
The term synteny was originally defined to mean that two gene loci share the same chromosome. In a genomic context we refer to syntenic regions if both sequence and gene order is conserved between two [closely related] species. Source (Link now broken)
Two genes which occur on the same chromosome are syntenic; however, syntenic genes may or may not be "linked." Source: NHBLI/NCBI Glossary
In classical genetics, synteny describes the physical co-localization of genetic loci on the same chromosome within an individual or species. Source
http://schaechter.asmblog.org/schaechter/2008/12/of-terms-in-biology-synteny.html
Geneticists are known for having developed a language of their own. So is just about everybody else in science. Ergo, looking up definitions is often a necessity. Today’s term is synteny (which etymologically means “on the same ribbon”). You might think that we don't need worry about this so much in bacteria and archaea, the majority of whom have a single chromosome. All their genes are syntenic by definition. Synteny applies to multichromosomal organisms—of which there is a sizeable number within the bacteria, e.g., Rhodobacter spheroides (where this was first observed), Burkholderia cepacia, and some vibrios, brucellas, leptospiras, and rhizobia. Anyhow, we went ahead and looked up synteny. We were hoping for some enlightenment to share with you. Were we successful? Here are the results.
The occurrence of two or more loci on the same chromosome, without regard to the distance between them. Source
Portions of chromosomes in which gene order is conserved. Source
The term synteny was originally defined to mean that two gene loci share the same chromosome. In a genomic context we refer to syntenic regions if both sequence and gene order is conserved between two [closely related] species. Source (Link now broken)
Two genes which occur on the same chromosome are syntenic; however, syntenic genes may or may not be "linked." Source: NHBLI/NCBI Glossary
In classical genetics, synteny describes the physical co-localization of genetic loci on the same chromosome within an individual or species. Source
05-21 22:13
刘进平
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Synteny
In classical genetics, synteny describes the physical co-localization of genetic loci on the same chromosome within an individual or species. Today, however, biologists usually refer to synteny as the conservation of blocks of order within two sets of chromosomes that are being compared with each other. This concept can also be referred to as shared synteny.
https://en.wikipedia.org/wiki/Synteny
In classical genetics, synteny describes the physical co-localization of genetic loci on the same chromosome within an individual or species. Today, however, biologists usually refer to synteny as the conservation of blocks of order within two sets of chromosomes that are being compared with each other. This concept can also be referred to as shared synteny.
https://en.wikipedia.org/wiki/Synteny
05-21 22:29
刘进平
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Synteny
Synteny is a valid deduction that two or more genomic regions are derived from a single ancestral genomic region. Syntenic region can be from different organisms and are derived from speciation, or from the same genome and are derived from genome duplication events (such as polyploidy). One method for inferring synteny is through evidence based on collinearity of genomic content such as genes. If two regions have obvious collinear genomic features, they are syntenous. However, many noncollinear regions may be logically rearranged (e.g. through inversions) into a common ancestor, and thus be syntenous.
Syntenic block: This term refers to a set of syntenic genomic regions and is usually comprised of syntenic gene sets. Syntenic blocks are of interest to researchers as a unit of evolutionary history that may be used for additional studies such as:
genome evolution
ancestral genome reconstruction
gene family evolution
origin of gene family duplicates
https://genomevolution.org/wiki/index.php/Synteny
Synteny is a valid deduction that two or more genomic regions are derived from a single ancestral genomic region. Syntenic region can be from different organisms and are derived from speciation, or from the same genome and are derived from genome duplication events (such as polyploidy). One method for inferring synteny is through evidence based on collinearity of genomic content such as genes. If two regions have obvious collinear genomic features, they are syntenous. However, many noncollinear regions may be logically rearranged (e.g. through inversions) into a common ancestor, and thus be syntenous.
Syntenic block: This term refers to a set of syntenic genomic regions and is usually comprised of syntenic gene sets. Syntenic blocks are of interest to researchers as a unit of evolutionary history that may be used for additional studies such as:
genome evolution
ancestral genome reconstruction
gene family evolution
origin of gene family duplicates
https://genomevolution.org/wiki/index.php/Synteny
05-21 22:33
