RNA结构好火啊，这一期cell好几篇相关的文章。 On the cover: A virus must achieve a number of functions in its life cycle, often using a compact genome with a limited number of encoded proteins. As a result, many viral proteins are multifunctional. In this issue, Bornholdt, et al. (pp. 7 ...
The germ-cell lineage ensures the continuity of life through the generation of male and female gametes, which unite to form a totipotent zygote.Wehave previously demonstrated that, by using cytokines, embryonic stem cells and induced pluripotent stem cells can be induced into epiblast-like cells ( ...
8 August, 2013 Volume 51, Issue 3 On the cover: Cell-specific transcriptional responses to extra- and intracellular signals require the combined activities of promoters and enhancers. Although recent studies suggest a hierarchical model in which lineage-determining factors prime cell-speci ...
1 August, 2013 Volume 154, Issue 3 On the cover: Feeding Drosophila a diet high in sugar leads to metabolic defects, including hyperglycemia, hyperinsulinemia, and insulin resistance. In this issue, Hirabayashi et al. (pp. 664–675) now show that high dietary sugar converts Ras/Src-tra ...
Epigenetic phenomenon of dosage compensation in Drosophila is mediated by the male-specific lethal (MSL) complex, which contains two large noncoding roX RNAs in Drosophila . How these RNAs interact with the MSL proteins remains poorly understood. In this study, Ilik et al. (156–173) ...
某次会议上我问过某大牛类似的问题， 我本以为会是***先把这个文章发出来。科研竞争惨烈，旁观者enjoy成果吧 ~ Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice. Hu YC , de Rooij DG , Page DC . Source Whitehead Institute, ...
Arginine Methylation Initiates BMP-Induced Smad Signaling 11 July, 2013 Volume 51, Issue 1 On the cover: Signaling by cell-surface receptors is commonly mediated by kinases, resulting in phosphorylation of receptors and signaling effectors. The TGF-β-related BMP ligands act as growth ...
Genetic and Neural Mechanisms that Inhibit Drosophila from Mating with Other Species 3 July, 2013 Volume 154, Issue 1 On the cover: Developmental mechanisms generate interspecies hybrids that cannot propagate, as alluded to by the artist's depiction of the mythical Minotaur's labyri ...
Androgen deprivation therapy (ADT) is widely used in the treatment of metastatic, recurrent and locally advanced prostate cancer. However, ADT, which leads to castrate testosterone level, is associated with numerous side effects, such as sexual dysfunction, osteoporosis, obesity and cardiovascu ...
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