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天然化学物助力器官再生

已有 2751 次阅读 2013-7-31 16:52 |个人分类:小楼一夜听春雨——翻译|系统分类:海外观察| 组织, 天然, 器官, 再生, 化学物


·                           安迪·科格伦 20137301244

你的身体内有一种天然的化学物质,可以帮助器官再生,加快伤口愈合。

因为环氧二十碳三烯酸(EETs)有助于形成新血管,所以波士顿哈佛医学院的迪帕克Dipak Panigrahy和他的同事就想知道这种物质是否也可能会加速其他种类器官组织的增长。为了找到答案,他们给小鼠直接注射EETs,然后通过外科手术切除它们肺或者肝的一部分。

四天之后,与安慰剂组相比,有23%的肺切除小鼠出现了肺部再生,46%以上的肝切除小鼠肝脏出现了再生。应用EETs的小鼠伤口愈合时间明显缩短。

研究小组还发现,人类肝脏捐赠者经历手术后,血液中的EET浓度在注射后一周内翻了三番。

这看起来很有希望,丹·魏斯说。他在伯灵顿佛蒙特大学研究肺再生。

“EETs在生化与再生的研究中被忽视了,所以这可能是提供给我们一个机会来研究它。

期刊参考:PNASDOI10.1073/pnas.1311565110

Natural chemical boosts organregeneration

·                           12:44 30 July 2013 by Andy Coghlan

Yourbody naturally contains a chemical that can boost organ regenerationand speed up wound healing.

Epoxyeicosatrienoic acids(EETs) help new blood vessels to form, so Dipak Panigrahy at Harvard MedicalSchool in Boston and colleagues wondered whether theymight also accelerate other types of growth. To find out, they injected micewith EETs straight after the surgical removal of a lung or part of their liver.

Four days later, treatedmice had 23 per cent more tissue growth in their remaining lung or 46 per centmore liver growth compared with mice that had received a placebo injection.Applying EETs to wounds in mice shortened healing time.

The team also showed thatEET concentrations in blood trebled in the week after human liver donors hadundergone surgery.

"This lookspromising," says Dan Weiss, who studies lung regeneration at the University of Vermontin Burlington.

"EETshave been overlooked in regeneration schemes, so this might provide a window ofopportunity."

http://www.newscientist.com/article/dn23960-natural-chemical-boosts-organ-regeneration.html#.Ufiqyjvigrc




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