突破一: JAMA— 科学家发现血浆 P-tau217 是 AD 的诊断生物标志物,效能堪比 CSF 标志物和 PET 标志物 Abstract Importance:There are limitations in current diagnostic testing approaches forAlzheimer disease (AD). Objective:To examine plasma tau phosphorylated a ...
突破一: Cell —科学家聚焦 tau 蛋白翻译后修饰,阐明 tau 蛋白翻译后修饰和疾病异质性和疾病病理阶段的联系,揭示 tau 蛋白翻译后修饰与 tau 纤维结构的相关性。 Abstract1 Toelucidate the role of Tau isoforms and post-translational modification (PTM)stoichiometry in Alzheimer's ...
2019年自闭症十大研究突破 1. Nature—IL-17a 可以改善自闭症谱系疾病的社会性行为 英文摘要: Asubsetof children with autism spectrum disorderappear to show an improvement in theirbehavioural symptoms during the course of a fever, a s ...
2019年大脑学习和记忆的十大研究突破 1.Nature— 科学家揭示了运动皮层短期记忆引导未来运动的吸引子动力学原理 英文摘要: Short-termmemories link events separated in time, such as past sensation and futureactions. Short-term memories are correlated with slow neural ...
2019年神经发育及成年神经再生十大研究突破 1. Nature— 脊椎动物“新大脑 “ 的进化依赖于神经嵴调节性神经环路的逐渐获得 英文摘要: The neural crest, an embryonic stem-cell population, is avertebrate innovation that has been proposed to be a key component of the & ...
2019年睡眠和失眠领域十大研究突破 1. Nat Genet— 失眠是遗传的吗?全基因组关联研究发现一系列和人类失眠相关的基因变异 英文摘要 1 : Insomniais a common disorder linked with adverse long-term medical and psychiatricoutcomes. The underlying pathophysiological pro ...
2019年衰老和长寿十大研究突破 1. Cell— 线粒体通透性决定了自噬是延长寿命还是缩短寿命 英文摘要: Autophagyis required in diverse paradigms of lifespan extension, leading to theprevailing notion that autophagy is beneficial for longevity.However, why autophagy is ...
2019年癫痫领域十大研究突破 1. Lancet— 治疗肥胖的药物盐酸氟苯丙胺可显著改善 Dravet 综合征的癫痫症状 英文摘要: BACKGROUND: Dravetsyndrome is a rare, treatment-resistant developmental epileptic encephalopathycharacterised by multiple types of frequent, disa ...
2019年疼痛防治和痛觉机制十大研究突破 1.N Engl J Med+Lancet— 人源化抗 CGRP 抗体或者 CGRP 阻断剂防治偏头痛取得较好疗效 英文摘 :1 : BACKGROUND: Antibodiestargeting calcitonin gene-related peptide (CGRP) or its receptor have shownefficacy in the prevention of m ...
2019年神经内科十大临床研究突破 1. N Engl J Med +Lancet— 改变指南:最新研究支持卒中后 4.5-9 小时采取静脉溶栓对某些患者是有益处的 英文摘要 1 : BACKGROUND: Strokethrombolysis with alteplase is currently recommended 0-4·5 h after strokeonset. We aimed to determ ...