Nature medicine—外周CX3CR1+单核细胞通过TNF-α调控学习及其依赖的树突棘重塑过程

Summary

1. Systemic immune challenge increases dendritic spine turnover in the cortex.

2. Systemic immune challenge impairs learning-dependent spine remodeling and performance improvement.

3. CX3CR1+ cells are required for altered dendritic spine plasticity after systemic immune challenge.

4. CX3CR1+ monocytes, but not microglia, mediate synaptic and learning deficits after systemic immune challenge.

5. Cx3cr1−/− chimeric mice do not show synaptic and learning deficits after systemic immune challenge.

6. TNF-α mediates synaptic and learning deficits after systemic immune challenge.