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Nature neurosci——激活皮层SOM中间神经元可以防治神经病理性疼痛
Summary
1.Elevated L5 pyramidal somatic Ca2+ activity in S1 after peripheral nerve injury.
2.Enhanced dendritic spine and branch activity in S1 of neuropathic pain mice.
3.Elevated dendritic Ca2+ spike generation in apical tuft branches and trunks of L5 pyramidal neurons in S1 of neuropathic pain mice.
4.Alterations in inhibitory neuronal Ca2+ activity in S1 of neuropathic pain mice.
5.Acute activation of SOM neurons in S1 reduces L5 pyramidal neuron activity in mice with neuropathic pain.
6.Daily activation of SOM neurons following peripheral nerve injury prevents the development of neuropathic pain.
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