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癌症研究的一个简单且重大的最新进展 精选

已有 9748 次阅读 2011-12-17 04:43 |系统分类:论文交流| 癌症, 知识产权, 化疗, 节食, 副作用

因为担任某学生博士答辩委员会主席之职,昨天陪论文的outside examiner一起吃了个晚饭。此人是南加州大学的教授Dr. Valter Longo。这个意大利人比本博主才大两岁,但已是南加大的正教授,差距有多大可想而知。这个Dr. Longo很能喝酒,感觉他自己就整了快一瓶红酒。酒多话就多,不过咱听着还是很受启发的。起码我再一次领会到了经常要step back for a bigger picture的重要性,经常要问一下自己的研究有没有用。

半个小时前刚听完他的学术报告,按捺不住激动想和大家分享一下这位研究衰老的人最近关于癌症的最新发现。简单来讲就是生长激素受体有缺陷的人,虽然个子长不高,但不容易老,一辈子也不得癌症和糖尿病!

Sci Transl Med. 2011 Feb 16;3(70):70ra13.
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.

Institute of Endocrinology, Metabolism and Reproduction, Quito, Ecuador. jguevara@iemyr-ecuador.org


Abstract

Mutations in growth signaling pathways extend life span, as well as protect against age-dependent DNA damage in yeast and decrease insulin resistance and cancer in mice. To test their effect in humans, we monitored for 22 years Ecuadorian individuals who carry mutations in the growth hormone receptor (GHR) gene that lead to severe GHR and IGF-1 (insulin-like growth factor-1) deficiencies. We combined this information with surveys to identify the cause and age of death for individuals in this community who died before this period. The individuals with GHR deficiency exhibited only one nonlethal malignancy and no cases of diabetes, in contrast to a prevalence of 17% for cancer and 5% for diabetes in control subjects. A possible explanation for the very low incidence of cancer was suggested by in vitro studies: Serum from subjects with GHR deficiency reduced DNA breaks but increased apoptosis in human mammary epithelial cells treated with hydrogen peroxide. Serum from GHR-deficient subjects also caused reduced expression of RAS, PKA (protein kinase A), and TOR (target of rapamycin) and up-regulation of SOD2 (superoxide dismutase 2) in treated cells, changes that promote cellular protection and life-span extension in model organisms. We also observed reduced insulin concentrations (1.4 μU/ml versus 4.4 μU/ml in unaffected relatives) and a very low HOMA-IR (homeostatic model assessment-insulin resistance) index (0.34 versus 0.96 in unaffected relatives) in individuals with GHR deficiency, indicating higher insulin sensitivity, which could explain the absence of diabetes in these subjects. These results provide evidence for a role of evolutionarily conserved pathways in the control of aging and disease burden in humans.


更重要的是,他们据此发现节食(fasting,可抑制生长激素的作用)可以让正常细胞启动自我保护程序,而癌细胞不会。据此他们提出癌症化疗前后节食让正常细胞启动自我保护以减轻化疗副作用。根据他们的初步临床实验发现化疗前3-5天加化疗后一天内的节食可以大大减轻化疗的副作用。具体指标就不细讲了。个人认为这个研究就像是喝点儿青蒿素就可以治疟疾一样,简单易行,管用,还不容易有知识产权问题。国内搞癌症临床化疗的同胞有机会试一下吧。


纽约时报报道:

“Ecuadorean Dwarfs with Laron Syndrome Don't Get Cancer or Diabetes”


Valter Longo:

图片来自网络。


https://wap.sciencenet.cn/blog-590130-519240.html

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