scimage的官方机构博客分享 http://blog.sciencenet.cn/u/scimage 嘲风,傲立檐头,风雨无惧; 静远,宁静致远,气定神闲。

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大脑内的‘神秘宇宙’

已有 884 次阅读 2022-6-17 14:56 |个人分类:封面故事|系统分类:论文交流


夜幕降临时抬头看,每一颗闪亮的星都是一颗星球。数不清的星星也代表着无数的星球。离地球越近,越亮。散发着微光的星星看起来很近,实际离我们不知道有几亿甚至几十亿光年的距离。

比九重天更远的,是宇宙。对求知欲的渴望不断地吸引着人们对它进行探索。独特的魅力让科学家们对它“欲罢不能”。


普通人是一辈子都不可能近距离接触到了。但在我们身边,其实还有一个“神秘宇宙”。


人体内部就像一个小型宇宙,各部门按部就班日复一日,以保证人体机能正常。部门里除了各司其职的大佬如心肝脾胃肾等统领部门之外的,更多的是被到处使唤的细胞小兵。

如白细胞红细胞血小板。体检过的人都知道的。

“多巴胺的刺激只有三个月,所以恋爱只有三个月的保质期.....”多巴胺,陷入失恋的人常说的一个词。


你问我还有别的吗?那可就多了去了。比如下面这个


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原文链接:https://www.scimage.cn/artwork/3268.html


Eryan Yang, Lin Wang, Weili Jin, Xing Liu, Qixue Wang, Ye Wu, Yanli Tan, Yunfei Wang, Xiaoteng Cui, Jixing Zhao, Fei Tong, Biao Hong, Menglin Xiao, Xiaomin Liu, Chuan Fang, Chunsheng Kang团队于Theranostics发表的关于PTRF/Cavin-1 enhances chemo-resistance and promotes temozolomide efflux through extracellular vesicles in glioblastoma


文章摘要:

Background: The concentration and duration of intracellular drugs have always been the key factors for determining the efficacy of the treatment. Efflux of chemotherapeutic drugs or anticancer agents is a major reason for multidrug resistance generation in cancer cells. The high expression of polymerase I and transcript release factor (PTRF) is correlated with a worse prognosis in glioma patients. However, the importance of PTRF on temozolomide (TMZ) resistance in glioblastoma (GBM) is poorly understood.

Methods: TCGA data analysis, CGGA data analysis, transmission electron microscopy (TEM), scanning electron microscopy (SEM), clone formation, cell counting kit-8 (cck-8), western blot (WB), immunofluorescence (IF), immunohistochemistry (IHC) and flow cytometry assays were performed to investigate the underlying mechanism and effect of PTRF on TMZ-resistance in a variety of GBM cell lines and GBM patient-derived xenograft (PDX) models. Clone formation, WB, IF, IHC and flow cytometry assays were performed to examine the efficacy of sequential therapy of TMZ followed by CQ in GBM cells and PDX models.

Results: The prognosis of GBM patients treated with TMZ was negatively correlated with PTRF expression. Our results reveal that PTRF knockdown significantly decrease proliferation and increase apoptosis in GBM after TMZ treatment. Moreover, PTRF contribute to TMZ-resistance by increasing TMZ efflux through extracellular vesicles (EVs). Furthermore, our results demonstrate that sequential therapy of TMZ followed by CQ significantly promotes the TMZ efficacy against GBM by increasing intracellular TMZ concentration ([TMZ]i).

Conclusion: This study highlights that PTRF can act as an independent biomarker to predict the prognosis of GBM patients after TMZ treatment and describes a new mechanism contributing to TMZ-resistance. In addition, this study may provide a novel idea for GBM therapy.

Keywords: Glioblastoma, temozolomide, PTRF, extracellular vesicles, chloroquine


PS:封面设计由科研团队与嘲风团队共同完成。点击官网,查看更多。

https://www.scimage.cn/


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静远嘲风(MY Scimage) 成立于2007年,嘲风取自中国传统文化中龙生九子,子子不同的传说,嘲风为守护屋脊之瑞兽,喜登高望远;静远取自成语“宁静致远”,登高莫忘初心,远观而不可务远。

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