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云师大职业技术教育学院王永超副教授在《Organic Letters》发表文章最新研究文章

已有 504 次阅读 2024-5-19 16:10 |个人分类:云师大研究|系统分类:论文交流

 2024年5月14日,ACS旗下国际著名期刊《Organic Letters》在线发表了云南师范大学职业技术教育学院王永超副教授的最新研究成果《Switchable Skeletal Rearrangement of Hexahydro-4H-indol-4-ones: Divergent Synthesis of Dihydroxy-4H-cyclopenta[b]pyridin-4-ones and 8-Alkenyl Oxepane-2,6-diones》。云南师范大学职业技术教育学院王永超为通讯作者,昆明理工大学余富朝为共同通讯作者。第一单位为昆明理工大学生命科学与技术学院。

https://pubs.acs.org/doi/10.1021/acs.orglett.4c00908

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Abstract

Abstract Image

An unprecedented base-controlled selective skeletal rearrangement reaction of hexahydro-4H-indol-4-ones has been developed. In this protocol, highly functionalized dihydroxy-4H-cyclopenta[b]pyridin-4-ones and 8-alkenyl oxepane-2,6-diones were prepared with a broad substrate scope and high chemoselectivity in moderate to excellent yields selectively by modulating LiOH and Et3N. In addition, the newly formed 8-alkenyl oxepane-2,6-dione scaffolds could be easily further derivatized to 5-(pyrrol-2-yl)dihydrofuran-2(3H)-ones through a rare intramolecular rearrangement reaction.



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