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博文

云南师范大学杰出校友之牛昱宇教授

已有 897 次阅读 2023-11-27 19:59 |个人分类:云师大之事|系统分类:人物纪事

牛昱宇,男,汉族,1977年2月生,教授,博士生导师,长期从事灵长类基因编辑与胚胎发育方向的研究,中国遗传学会基因组编辑分会委员,

教育部大长江。1999年毕业于云南师范大学生命科学学院生物系。

一、学历及工作经历

1995-1999 云南师范大学生物系,生物学,学士

2001-2007 中国科学院昆明动物研究所,动物学,博士

2006-2008,德国柏林野生与笼养动物研究所,访问学者

2007-2014 中国科学院昆明动物研究所,副研究员

2014-至今 昆明理工大学灵长类转化医学研究院,副院长,教授,博士生导师

2019-至今 昆明理工大学生命科学与技术学院,院长,教授,博士生导师

2022.10--任昆明理工大学副校长。

二、开设课程

《细胞工程》、《发育生物学》、《生物学学科前沿讲座》 

三、研究领域

灵长类基因编辑

灵长类胚胎发育与疾病

早期胚胎发育是哺乳动物生命发生的重要阶段,这一时期的关键生物学事件,如合子基因启动,表观遗传维持与重建,胚层分化和器官形成等等,是发育生物学的重要基础理论,又和人类健康和疾病密切相关。然而,我们对其中的诸多科学问题却知之甚少。本实验室结合灵长类早期胚胎(体外受精,单性生殖和体细胞核移植)培养,基因编辑,干细胞与示踪,单细胞组学和灵长类疾病动物模型等技术体系,系统研究灵长类细胞多能性的维持与重建,表观遗传维持与胚层分化的关系,退行性疾病的早期诊断和干预等等重要科学问题,以期揭示人类生命发生和疾病形成的奥秘。 

四、主持项目

1. 国家重点研发计划“干细胞及转化研究”专项项目,2016YFA0101400,靶向基因编辑建立神经系统疾病猴模型及干细胞治疗研究,2016-2012,2915万元,首席科学家。

2. 国家自然科学基金联合重点项目,U1302227,帕金森氏症转基因灵长类动物模型的构建与致病机理研究,2014-2017,210万元,项目负责人

3. 国家重大科学研究计划(973计划),2012CBA01304,神经退行疾病致病机理及转基因动物模型的建立,2012/01-2016/12,420万元,课题负责人。

4. 国家高技术研究发展计划(863计划),2012AA020701,神经退行性疾病灵长类动物模型制备关键技术及利用,2012/01-2015/12,710万元,课题负责人。

5. 国家科技重大专项,2009ZX09501-028,评价抗HCV化学药物疗效和安全性的动物模型,2009/01-2011/12,690万元,已结题,项目负责人。 [1]

四、学术论文

AuthorsArticle TitleSource TitleVolumeIssueStart PageEnd PagePublication Year
Zhang, Hui; Li, Jiaming; Yu, Yang; Ren, Jie; Liu, Qiang; Bao, Zhaoshi; Sun, Shuhui; Liu, Xiaoqian; Ma, Shuai; Liu, Zunpeng; Yan, Kaowen; Wu, Zeming; Fan, Yanling; Sun, Xiaoyan; Zhang, Yixin; Ji, Qianzhao; Cheng, Fang; Wei, Peng-Hu; Ma, Xibo; Zhang, Shiqiang; Xie, Zhengwei; Niu, Yuyu; Wang, Yan-Jiang; Han, Jing-Dong J; Jiang, Tao; Zhao, Guoguang; Ji, Weizhi; Izpisua Belmonte, Juan Carlos; Wang, Si; Qu, Jing; Zhang, Weiqi; Liu, Guang-HuiNuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging.Cell reports42111133961133962023
Niu, Yuyu; Wang, Guifang; Feng, Xianjun; Niu, Hongyi; Shi, WenruiSignificance of fatty liver index to detect prevalent ischemic heart disease: evidence from national health and nutrition examination survey 1999-2016FRONTIERS IN CARDIOVASCULAR MEDICINE10


2023
Wu, Junmo; Kang, Yu; Luo, Xiang; Dai, Shaoxing; Shi, Yuxi; Li, Zhuoyao; Tang, Zengli; Chen, Zhenzhen; Zhu, Ran; Yang, Pengpeng; Li, Zifan; Wang, Hong; Chen, Xinglong; Zhao, Ziyi; Ji, Weizhi; Niu, YuyuLong-term in vivo chimeric cells tracking in non-human primatePROTEIN & CELL



2023
Xu, Lizhu; Wang, Dan; Zhao, Lu; Yang, Zhengsheng; Liu, Xu; Li, Xinyue; Yuan, Tingli; Wang, Ye; Huang, Tianzhuang; Bian, Ning; He, Yuqun; Chen, Xinglong; Tian, Baohong; Liu, Zexian; Luo, Fucheng; Si, Wei; Gao, Guangping; Ji, Weizhi; Niu, Yuyu; Wei, JingkuanC9orf72 poly(PR) aggregation in nucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeysNEUROBIOLOGY OF DISEASE184


2023
Zhang, Hui; Li, Jiaming; Yu, Yang; Ren, Jie; Liu, Qiang; Bao, Zhaoshi; Sun, Shuhui; Liu, Xiaoqian; Ma, Shuai; Liu, Zunpeng; Yan, Kaowen; Wu, Zeming; Fan, Yanling; Sun, Xiaoyan; Zhang, Yixin; Ji, Qianzhao; Cheng, Fang; Wei, Peng-Hu; Ma, Xibo; Zhang, Shiqian; Xie, Zhengwei; Niu, Yuyu; Wang, Yan-Jiang; Han, Jing-Dong J.; Jiang, Tao; Zhao, Guoguang; Ji, Weizhi; Belmonte, Juan Carlos Izpisua; Wang, Si; Qu, Jing; Zhang, Weiqi; Liu, Guang-HuiNuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal agingCELL REPORTS426

2023
Gong, Yandong; Bai, Bing; Sun, Nianqin; Ci, Baiquan; Shao, Honglian; Zhang, Ting; Yao, Hui; Zhang, Youyue; Niu, Yuyu; Liu, Lizhong; Zhao, Hu; Wu, Hao; Zhang, Lei; Wang, Tianxiang; Li, Shangang; Wei, Yulei; Yu, Yang; Orsi, Ana Elisa Ribeiro; Liu, Bing; Ji, Weizhi; Wu, Jun; Chen, Yongchang; Tan, TaoEx utero monkey embryogenesis from blastocyst to early organogenesisCELL186102092+2023
Liu, Yan; Shan, Liang; Liu, Tiane; Li, Juan; Chen, Yongchang; Sun, Changhong; Yang, Chaojuan; Bian, Xiling; Niu, Yuyu; Zhang, Chen; Xi, Jianzhong; Rao, YiMolecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocinNEURON11191468+2023
Li, Shuang; Chen, Zhenzhen; Chen, Chuanxin; Niu, YuyuMultiplexed single-cell transcriptome analysis reveals molecular characteristics of monkey pluripotent stem cell linesJOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B2454184292023
Liu, Xiaoqian; Liu, Zunpeng; Wu, Zeming; Ren, Jie; Fan, Yanling; Sun, Liang; Cao, Gang; Niu, Yuyu; Zhang, Baohu; Ji, Qianzhao; Jiang, Xiaoyu; Wang, Cui; Wang, Qiaoran; Ji, Zhejun; Li, Lanzhu; Esteban, Concepcion Rodriguez; Yan, Kaowen; Li, Wei; Cai, Yusheng; Wang, Si; Zheng, Aihua; Zhang, Yong E.; Tan, Shengjun; Cai, Yingao; Song, Moshi; Lu, Falong; Tang, Fuchou; Ji, Weizhi; Zhou, Qi; Belmonte, Juan Carlos Izpisua; Zhang, Weiqi; Qu, Jing; Liu, Guang-HuiResurrection of endogenous retroviruses during aging reinforces senescenceCELL1862287+2023
Li, Mengjia; Wang, Zhengbo; Zheng, Tianqi; Huang, Tianzhuang; Liu, Baoguo; Han, Deqiang; Liu, Sumei; Liu, Bochao; Li, Mo; Si, Wei; Zhang, Y. Alex; Niu, Yuyu; Chen, ZhiguoCharacterization of Human-Induced Neural Stem Cells and Derivatives following Transplantation into the Central Nervous System of a Nonhuman Primate and RatsSTEM CELLS INTERNATIONAL2022


2022
Lei, Ying; Cheng, Mengnan; Li, Zihao; Zhuang, Zhenkun; Wu, Liang; Sun, Yunong; Han, Lei; Huang, Zhihao; Wang, Yuzhou; Wang, Zifei; Xu, Liqin; Yuan, Yue; Liu, Shang; Pan, Taotao; Xie, Jiarui; Liu, Chuanyu; Volpe, Giacomo; Ward, Carl; Lai, Yiwei; Xu, Jiangshan; Wang, Mingyue; Yu, Hao; Sun, Haixi; Yu, Qichao; Wang, Chunqing; Wong, Chi Wai; Liu, Wei; Xu, Liangzhi; Wei, Jingkuan; Chen, Dandan; Shang, Zhouchun; Li, Guibo; Ma, Kun; Cheng, Le; Ling, Fei; Tan, Tao; Chen, Kai; Tasic, Bosiljka; Dean, Michael; Ji, Weizhi; Yang, Huanming; Gu, Ying; Esteban, Miguel A.; Li, Yuxiang; Chen, Ao; Niu, Yuyu; Zeng, Hongkui; Hou, Yong; Liu, Longqi; Liu, Shiping; Xu, XunSpatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortexNATURE COMMUNICATIONS131

2022
Bai, Bing; Wang, Yi; Zhu, Ran; Zhang, Yaolei; Wang, Hong; Fan, Guangyi; Liu, Xin; Shi, Hong; Niu, Yuyu; Ji, WeizhiLong-read sequencing and de novo assembly of the cynomolgus macaque genomeJOURNAL OF GENETICS AND GENOMICS49109759782022
Zheng, Yi; Yan, Robin Zhexuan; Sun, Shiyu; Kobayashi, Mutsumi; Xiang, Lifeng; Yang, Ran; Goedel, Alexander; Kang, Yu; Xue, Xufeng; Esfahani, Sajedeh Nasr; Liu, Yue; Irizarry, Agnes M. Resto; Wu, Weisheng; Li, Yunxiu; Ji, Weizhi; Niu, Yuyu; Chien, Kenneth R.; Li, Tianqing; Shioda, Toshihiro; Fu, JianpingSingle-cell analysis of embryoids reveals lineage diversification roadmaps of early human developmentCELL STEM CELL2991402+2022
Jin Xuan; Du Juan; Niu Yuyu; Ji AnjingImpact of estimated glucose disposal rate for identifying prevalent ischemic heart disease: findings from a cross-sectional studyBMC CARDIOVASCULAR DISORDERS221

2022
De los Angeles, Alejandro; Regenberg, Alan; Mascetti, Victoria; Benvenisty, Nissim; Church, George; Deng, Hongkui; Belmonte, Juan Carlos Izpisua; Ji, Weizhi; Koplin, Julian; Loh, Yuin-Han; Niu, Yuyu; Pei, Duanqing; Pera, Martin; Pho, Nam; Pinzon-Arteaga, Carlos; Saitou, Mitinori; Silva, Jose C. R.; Tao, Tan; Trounson, Alan; Warrier, Tushar; Zambidis, Elias T.Why it is important to study human-monkey embryonic chimeras in a dishNATURE METHODS1989149192022
Kang, Yu; Dai, Shaoxing; Zeng, Yuqiang; Wang, Fang; Yang, Pengpeng; Yang, Zhaohui; Pu, Youwei; Li, Zifan; Chen, Xinglong; Tian, Baohong; Si, Wei; Ji, Weizhi; Niu, YuyuCloning and base editing of GFP transgenic rhesus monkey and off-target analysisSCIENCE ADVANCES829

2022
Zhu, Xiaoqing; Guo, Yicheng; Chu, Chu; Liu, Dahai; Duan, Kui; Yin, Yu; Si, Chenyang; Kang, Yu; Yao, Junjun; Du, Xuewei; Li, Junliang; Zhao, Shumei; Ai, Zongyong; Zhu, Qingyuan; Ji, Weizhi; Niu, Yuyu; Li, TianqingBRN2 as a key gene drives the early primate telencephalon developmentSCIENCE ADVANCES89

2022
Cheng, Fuwei; Zhao, Shuangping; Li, Jiachen; Niu, Yuyu; Huang, Haiping; Yang, Jicheng; Ma, Shiyin; Liu, Jisheng; Sun, PengEnhanced effect of recombinant adenoviruses co-expression of ING4 and OSM on anti-tumour activity of laryngeal cancerJOURNAL OF CELLULAR AND MOLECULAR MEDICINE265155615662022
Zhong, Tao; Wei, Jingkuan; Wu, Kunhua; Chen, Liangjun; Zhao, Fenqiang; Pei, Yuchen; Wang, Ya; Zhang, Hongjiang; Wu, Zhengwang; Huang, Ying; Li, Tengfei; Wang, Li; Chen, Yongchang; Ji, Weizhi; Zhang, Yu; Li, Gang; Niu, YuyuLongitudinal brain atlases of early developing cynomolgus macaques from birth to 48 months of ageNEUROIMAGE247


2022
Chen, Chuanxin; Ji, Weizhi; Niu, YuyuPrimate Organoids and Gene-Editing Technologies toward Next-Generation Biomedical ResearchTRENDS IN BIOTECHNOLOGY3912133213422021
Chu, Chu; Zhang, Wenhao; Kang, Yu; Si, Chenyang; Ji, Weizhi; Niu, Yuyu; Zhang, YiAnalysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placentaDEVELOPMENTAL CELL56202826+2021
Xiao, Puhao; Bai, Raoxian; Zhang, Ting; Wu, Ruo; Chen, Lijiao; Hou, Yu; Shen, Bin; Niu, Yuyu; Li, Shangang; Ji, Weizhi; Chen, YongchangExtensive humoral immune response to AAVs and Cas proteins in nonhuman primatesSCIENCE BULLETIN6620206120642021
Yan, Yaping; Ren, Shuchao; Duan, Yanchao; Lu, Chenyu; Niu, Yuyu; Wang, Zhengbo; Inglis, Briauna; Ji, Weizhi; Zheng, Yun; Si, WeiGut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson's diseaseNPJ BIOFILMS AND MICROBIOMES71

2021
Yang, Ran; Goedel, Alexander; Kang, Yu; Si, Chenyang; Chu, Chu; Zheng, Yi; Chen, Zhenzhen; Gruber, Peter J.; Xiao, Yao; Zhou, Chikai; Witman, Nevin; Leung, Chuen-Yan; Chen, Yongchang; Fu, Jianping; Ji, Weizhi; Lanner, Fredrik; Niu, Yuyu; Chien, KennethAmnion signals are essential for mesoderm formation in primatesNATURE COMMUNICATIONS121

2021
Chen, Zhen-Zhen; Wang, Jian-Ying; Kang, Yu; Yang, Qiao-Yan; Gu, Xue-Ying; Zhi, Da-Long; Yan, Li; Long, Cheng-Zu; Shen, Bin; Niu, Yu-YuPINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeysZOOLOGICAL RESEARCH424469+2021
Tan, Tao; Wu, Jun; Si, Chenyang; Dai, Shaoxing; Zhang, Youyue; Sun, Nianqin; Zhang, E.; Shao, Honglian; Si, Wei; Yang, Pengpeng; Wang, Hong; Chen, Zhenzhen; Zhu, Ran; Kang, Yu; Hernandez-Benitez, Reyna; Martinez, Llanos Martinez; Delicado, Estrella Nunez; Berggren, W. Travis; Schwarz, May; Ai, Zongyong; Li, Tianqing; Deng, Hongkui; Esteban, Concepcion Rodriguez; Ji, Weizhi; Niu, Yuyu; Belmonte, Juan Carlos IzpisuaChimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo (vol 184, pg 2020, 2021)CELL18413358935892021
Xu, Hao; Niu, Yuyu; Sun, Yan; Xia, Menglin; Lin, Daozheng; Qiao, WeiSeparation and purification of magnoflorine, spinosin, and 6'-feruloyspinosin from Ziziphi Spinosae Semen by high-speed counter-current chromatographyJOURNAL OF SEPARATION SCIENCE4412239123982021
Tan, Tao; Wu, Jun; Si, Chenyang; Dai, Shaoxing; Zhang, Youyue; Sun, Nianqin; Zhang, E.; Shao, Honglian; Si, Wei; Yang, Pengpeng; Wang, Hong; Chen, Zhenzhen; Zhu, Ran; Kang, Yu; Hernandez-Benitez, Reyna; Martinez, Llanos Martinez; Delicado, Estrella Nunez; Berggren, W. Travis; Schwarz, May; Ai, Zongyong; Li, Tianqing; Esteban, Concepcion Rodriguez; Ji, Weizhi; Niu, Yuyu; Belmonte, Juan Carlos IzpisuaChimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivoCELL18482020+2021
Zhong, Tao; Zhao, Fenqiang; Pei, Yuchen; Ning, Zhenyuan; Liao, Lufan; Wu, Zhengwang; Niu, Yuyu; Wang, Li; Shen, Dinggang; Zhang, Yu; Li, GangDIKA-Nets: Domain-invariant knowledge-guided attention networks for brain skull stripping of early developing macaquesNEUROIMAGE227


2021
Wang, Fang; Zeng, Yuqiang; Wang, Yi; Niu, YuyuThe Development and Application of a Base Editor in BiomedicineBIOMED RESEARCH INTERNATIONAL2020


2020
Wang, Fang; Zhang, Weiqi; Yang, Qiaoyan; Kang, Yu; Fan, Yanling; Wei, Jingkuan; Liu, Zunpeng; Dai, Shaoxing; Li, Hao; Li, Zifan; Xu, Lizhu; Chu, Chu; Qu, Jing; Si, Chenyang; Ji, Weizhi; Liu, Guang-Hui; Long, Chengzu; Niu, YuyuGeneration of a Hutchinson-Gilford progeria syndrome monkey model by base editingPROTEIN & CELL11118098242020
Zhang, Ting; Kang, Yu; Li, Li; Zhou, Yin; Chen, Xinglong; Zhuo, Yan; Li, Zifan; Wang, Hong; Niu, Yuyu; Ji, Weizhi; Li, Shangang; Chen, YongchangInterspecies embryo transfer between rhesus and cynomolgus monkeysJOURNAL OF GENETICS AND GENOMICS4763333362020
Chen, Baohui; Niu, Yuyu; Wang, Haoyi; Wang, Kejian; Yang, Hui; Li, WeiRecent advances in CRISPR researchPROTEIN & CELL11117867912020
Li, Bin; Niu, Yuyu; Ji, Weizhi; Dong, YizhouStrategies for the CRISPR-Based TherapeuticsTRENDS IN PHARMACOLOGICAL SCIENCES41155652020
Xiang, Lifeng; Yin, Yu; Zheng, Yun; Ma, Yanping; Li, Yonggang; Zhao, Zhigang; Guo, Junqiang; Ai, Zongyong; Niu, Yuyu; Duan, Kui; He, Jingjing; Ren, Shuchao; Wu, Dan; Bai, Yun; Shang, Zhouchun; Dai, Xi; Ji, Weizhi; Li, TianqingA developmental landscape of 3D-cultured human pre-gastrulation embryosNATURE5777791537+2020
Niu, Yuyu; Sun, Nianqin; Li, Chang; Lei, Ying; Huang, Zhihao; Wu, Jun; Si, Chenyang; Dai, Xi; Liu, Chuanyu; Wei, Jingkuan; Liu, Longqi; Feng, Su; Kang, Yu; Si, Wei; Wang, Hong; Zhang, E.; Zhao, Lu; Li, Ziwei; Luo, Xi; Cui, Guizhong; Peng, Guangdun; Belmonte, Juan Carlos Izpisua; Ji, Weizhi; Tan, TaoDissecting primate early post-implantation development using long-term in vitro embryo cultureSCIENCE3666467837+2019
Wang, Dan; Niu, Yuyu; Ren, Lingzhi; Kang, Yu; Tai, Phillip W. L.; Si, Chenyang; Mendonca, Craig A.; Ma, Hong; Gao, Guangping; Ji, WeizhiGene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno-Associated VirusADVANCED SCIENCE621

2019
Kang, Yu; Chu, Chu; Wang, Fang; Niu, YuyuCRISPR/Cas9-mediated genome editing in nonhuman primatesDISEASE MODELS & MECHANISMS1210

2019
Chen, Zhen-Zhen; Niu, Yu-YuStem cell therapy for Parkinson's disease using non-human primate modelsZOOLOGICAL RESEARCH4053493572019
Zhang, Bo; Zhou, Zhigang; Zhou, Yin; Zhang, Ting; Ma, Yuanye; Niu, Yuyu; Ji, Weizhi; Chen, YongchangSocial-valence-related increased attention in rett syndrome cynomolgus monkeys: An eye-tracking studyAUTISM RESEARCH1211158515972019
Niu, YuyuGenetic monkeys reveal a new role for a longevity protein in embryonic developmentNATIONAL SCIENCE REVIEW633923922019
Shi, Lei; Luo, Xin; Jiang, Jin; Chen, Yongchang; Liu, Cirong; Hu, Ting; Li, Min; Lin, Qiang; Li, Yanjiao; Huang, Jun; Wang, Hong; Niu, Yuyu; Shi, Yundi; Styner, Martin; Wang, Jianhong; Lu, Yi; Sun, Xuejin; Yu, Hualin; Ji, Weizhi; Su, BingTransgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain developmentNATIONAL SCIENCE REVIEW634804932019
Wang, Dan; Niu, Yuyu; Ren, Lingzhi; Tai, Phillip W. L.; Ji, Weizhi; Gao, GuangpingGene Delivery to Non-Human Primate Embryos Using AAV VectorsMOLECULAR THERAPY2741101102019
Sun, Peng; Zhang, Dan; Huang, Haiping; Yu, Yafeng; Yang, Zhendong; Niu, Yuyu; Liu, JishengMicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14BBIOLOGICAL CHEMISTRY40022372462019
Chu, Chu; Yang, Zhaohui; Yang, Jiayin; Yan, Li; Si, Chenyang; Kang, Yu; Chen, Zhenzhen; Chen, Yongchang; Ji, Weizhi; Niu, YuyuHomologous recombination-mediated targeted integration in monkey embryos using TALE nucleasesBMC BIOTECHNOLOGY19


2019
Cao Jing; Li Mengjia; Wang Fang; Zeng Yuqiang; Wei Jingkuan; Niu YuyuPluripotent Stem Cells Differentiate into Motor Neurons in Cynomolgus MonkeysChinese Journal of Cell Biology4110197619852019
Kang, Yu; Ai, Zongyong; Duan, Kui; Si, Chenyang; Wang, Yong; Zheng, Yun; He, Jingjing; Yin, Yu; Zhao, Shumei; Niu, Baohua; Zhu, Xiaoqing; Liu, Li; Xiang, Lifeng; Zhang, Linming; Niu, Yuyu; Ji, Weizhi; Li, TianqingImproving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus MonkeysCELL REPORTS2592563+2018
Yan, Li; Jiang, Bin; Niu, Yuyu; Wang, Hongxuan; Li, Enqin; Yan, Yaping; Sun, Huiyan; Duan, Yanchao; Chang, Shaohui; Chen, Guokai; Ji, Weizhi; Xu, Ren-He; Si, WeiIntrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis modelCELL DEATH DISCOVERY4


2018
Wang, Shuang; Ren, Shuaiwei; Bai, Raoxian; Xiao, Puhao; Zhou, Qin; Zhou, Yin; Zhou, Zhigang; Niu, Yuyu; Ji, Weizhi; Chen, YongchangNo off-target mutations in functional genome regions of a CRISPR/Cas9-generated monkey model of muscular dystrophyJOURNAL OF BIOLOGICAL CHEMISTRY2933011654116582018
Cui, Yiqiang; Niu, Yuyu; Zhou, Jiankui; Chen, Yongchang; Cheng, Yiwei; Li, Shangang; Ai, Zongyong; Chu, Chu; Wang, Hong; Zheng, Bo; Chen, Xuejin; Sha, Jiahao; Guo, Xuejiang; Huang, Xingxu; Ji, WeizhiGeneration of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombinationCELL RESEARCH2833833862018
Chen Zhenzhen; Niu YuyuProgress on derivation of human embryonic stem cellChinese Bulletin of Life Sciences3089069102018
Wang, Shuang; Yang, Lichuan; Bai, Raoxian; Ren, Shuaiwei; Niu, Yuyu; Ma, Yuanye; Ji, Weizhi; Chen, YongchangInteraction of p53 and ASPPs regulates rhesus monkey embryonic stem cells conversion to neural fate concomitant with apoptosisCELL CYCLE179114611532018
Xin, Huijie; Fang, Leilei; Xie, Junbo; Qi, Wuqin; Niu, Yuyu; Yang, Fan; Cai, Dandan; Zhang, Yanqing; Wen, ZhiyouIdentification and Quantification of Triterpenoids in Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), with HPLC-MS/MS MethodsINTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS20109199342018
Zhuo, Yan; Feng, Shuqing; Huang, Shaoyong; Chen, Xinglong; Kang, Yu; Si, Chenyang; Li, Zifan; Zhou, Yin; Zhou, Ling; Zhang, Ting; Ji, Weizhi; Niu, Yuyu; Chen, YongchangTransabdominal ultrasound-guided multifetal pregnancy reduction in 10 cases of monkeysBIOLOGY OF REPRODUCTION9757587612017
Niu, Yuyu; Li, Tianqing; Ji, WeizhiPaving the road for biomedicine: genome editing and stem cells in primatesNATIONAL SCIENCE REVIEW445435492017
Chen, Yongchang; Yu, Juehua; Niu, Yuyu; Qin, Dongdong; Liu, Hailiang; Li, Gang; Hu, Yingzhou; Wang, Jiaojian; Lu, Yi; Kang, Yu; Jiang, Yong; Wu, Kunhua; Li, Siguang; Wei, Jingkuan; He, Jing; Wang, Junbang; Liu, Xiaojing; Luo, Yuping; Si, Chenyang; Bai, Raoxian; Zhang, Kunshan; Liu, Jie; Huang, Shaoyong; Chen, Zhenzhen; Wang, Shuang; Chen, Xiaoying; Bao, Xinhua; Zhang, Qingping; Li, Fuxing; Geng, Rui; Liang, Aibin; Shen, Dinggang; Jiang, Tianzi; Hu, Xintian; Ma, Yuanye; Ji, Weizhi; Sun, Yi EveModeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus MonkeysCELL1695945+2017
Wang, Dan; Yoon, Yeonsoo; Niu, Yuyu; Tai, Phillip W. L.; Riley, Joy; Ji, Weizhi; Rivera-Perez, Jaime A.; Gao, GuangpingEasy and Efficient Gene Editing of Mammalian Embryos Using rAAV Vectors - From Mouse to MonkeyMOLECULAR THERAPY25511112017
Gao, Fei; Niu, Yuyu; Sun, Yi Eve; Lu, Hanlin; Chen, Yongchang; Li, Siguang; Kang, Yu; Luo, Yuping; Si, Chenyang; Yu, Juehua; Li, Chang; Sun, Nianqin; Si, Wei; Wang, Hong; Ji, Weizhi; Tan, TaoDe novo DNA methylation during monkey pre-implantation embryogenesisCELL RESEARCH2745265392017
Fu, Xufeng; Yan, Yaping; Li, Shanshan; Wang, Junfeng; Jiang, Bin; Wang, Hong; Duan, Yanchao; Tan, Tao; Gao, Fei; Gong, Desheng; Niu, Yuyu; Ji, Weizhi; Zheng, Bingrong; Si, WeiVitrification of Rhesus Macaque Mesenchymal Stem Cells and the Effects on Global Gene ExpressionSTEM CELLS INTERNATIONAL2017


2017
Yan, Yaping; Ao, Lei; Wang, Hong; Duan, Yanchao; Chang, Shaohui; Chen, Bingbing; Zhi, Dalong; Li, Sujuan; Niu, Yuyu; Ji, Weizhi; Si, WeiCryopreservation of Cynomolgus Macaque (Macaca fascicularis) Sperm by Using a Commercial Egg-Yolk-Free Freezing MediumJOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE5567447482016
Zhu, Xiaoqing; Li, Bo; Ai, Zongyong; Xiang, Zheng; Zhang, Kunshang; Qiu, Xiaoyan; Chen, Yongchang; Li, Yuemin; Rizak, Joshua D.; Niu, Yuyu; Hu, Xintian; Sun, Yi Eve; Ji, Weizhi; Li, TianqingA Robust Single Primate Neuroepithelial Cell Clonal Expansion System for Neural Tube Development and Disease StudiesSTEM CELL REPORTS622282422016
Kang, Yu; Zheng, Bo; Shen, Bin; Chen, Yongchang; Wang, Lei; Wang, Jianying; Niu, Yuyu; Cui, Yiqiang; Zhou, Jiankui; Wang, Hong; Guo, Xuejiang; Hu, Bian; Zhou, Qi; Sha, Jiahao; Ji, Weizhi; Huang, XingxuCRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HHHUMAN MOLECULAR GENETICS2425725572642015
Zhi Dalong; Niu Yuyu; Ji WeizhiGenome Editing Technologies Based on Engineered NucleaseChinese Journal of Biochemistry and Molecular Biology3111113211372015
Wang, Hong; Tan, Tao; Wang, Junfeng; Niu, Yuyu; Yan, Yaping; Guo, Xiangyu; Kang, Yu; Duan, Yanchao; Chang, Shaohui; Liao, Jianpeng; Si, Chenyang; Ji, Weizhi; Si, WeiRhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysisSCIENTIFIC REPORTS5


2015
Chen, Yongchang; Niu, Yuyu; Li, Yanjiao; Ai, Zongyong; Kang, Yu; Shi, Hong; Xiang, Zheng; Yang, Zhaohui; Tan, Tao; Si, Wei; Li, Wei; Xia, Xueshan; Zhou, Qi; Ji, Weizhi; Li, TianqingGeneration of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem CellsCELL STEM CELL1711161242015
Chen, Yongchang; Zheng, Yinghui; Kang, Yu; Yang, Weili; Niu, Yuyu; Guo, Xiangyu; Tu, Zhuchi; Si, Chenyang; Wang, Hong; Xing, Ruxiao; Pu, Xiuqiong; Yang, Shang-Hsun; Li, Shihua; Ji, Weizhi; Li, Xiao-JiangFunctional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9HUMAN MOLECULAR GENETICS2413376437742015
Niu, Yuyu; Guo, Xiangyu; Chen, Yongchang; Wang, Chuan-En; Gao, Jinquan; Yang, Weili; Kang, Yu; Si, Wei; Wang, Hong; Yang, Shang-Hsun; Li, Shihua; Ji, Weizhi; Li, Xiao-JiangEarly Parkinson's disease symptoms in α-synuclein transgenic monkeysHUMAN MOLECULAR GENETICS248230823172015
Chen, Yongchang; Cui, Yiqiang; Shen, Bin; Niu, Yuyu; Zhao, Xiaoyang; Wang, Lei; Wang, Jianying; Li, Wei; Zhou, Qi; Ji, Weizhi; Sha, Jiahao; Huang, XingxuGermline acquisition of Cas9/RNA-mediated gene modifications in monkeysCELL RESEARCH2522622652015
Wan, Haifeng; Feng, Chunjing; Teng, Fei; Yang, Shihua; Hu, Baoyang; Niu, Yuyu; Xiang, Andy Peng; Fang, Weizhen; Ji, Weizhi; Li, Wei; Zhao, Xiaoyang; Zhou, QiOne-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas systemCELL RESEARCH2522582612015
Kang Yu; Chen Yongchang; Niu YuyuResearch progress of genome editing in nonhuman primatesChinese Bulletin of Life Sciences27150552015
Tan, Tao; Lu, Bin; Zhang, Jing; Niu, Yuyu; Si, Wei; Wei, Qiang; Ji, WeizhiNotch1 Signaling Antagonizes Transforming Growth Factor- b Pathway and Induces Apoptosis in Rabbit Trophoblast Stem CellsSTEM CELLS AND DEVELOPMENT2388138222014
Liu, Hailiang; Chen, Yongchang; Niu, Yuyu; Zhang, Kunshan; Kang, Yu; Ge, Weihong; Liu, Xiaojing; Zhao, Enfeng; Wang, Chencheng; Lin, Shaoyun; Jing, Bo; Si, Chenyang; Lin, Quan; Chen, Xiaoying; Lin, Haijun; Pu, Xiuqiong; Wang, Yingying; Qin, Binlian; Wang, Fang; Wang, Hong; Si, Wei; Zhou, Jing; Tan, Tao; Li, Tianqing; Ji, Shaohui; Xue, Zhigang; Luo, Yuping; Cheng, Liming; Zhou, Qi; Li, Siguang; Sun, Yi Eve; Ji, WeizhiTALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus MonkeysCELL STEM CELL1433233282014
Niu, Yuyu; Shen, Bin; Cui, Yiqiang; Chen, Yongchang; Wang, Jianying; Wang, Lei; Kang, Yu; Zhao, Xiaoyang; Si, Wei; Li, Wei; Xiang, Andy Peng; Zhou, Jiankui; Guo, Xuejiang; Bi, Ye; Si, Chenyang; Hu, Bian; Dong, Guoying; Wang, Hong; Zhou, Zuomin; Li, Tianqing; Tan, Tao; Pu, Xiuqiong; Wang, Fang; Ji, Shaohui; Zhou, Qi; Huang, Xingxu; Ji, Weizhi; Sha, JiahaoGeneration of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell EmbryosCELL15648368432014
Luo, Huanhua; Niu, Yuyu; Duan, Changqing; Su, Haijia; Yan, GuoliangA pH control strategy for increased β-carotene production during batch fermentation by recombinant industrial wine yeastPROCESS BIOCHEMISTRY4821952002013
Chen, Yongchang; Wang, Zhengbo; Xie, Yunhua; Guo, Xiangyu; Tang, Xianghui; Wang, Shufen; Yang, Shihua; Chen, Kai; Niu, Yuyu; Ji, WeizhiFolic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cellsJOURNAL OF NEUROSCIENCE RESEARCH907138213912012
Chen, Yongchang; Niu, Yuyu; Ji, WeizhiTransgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing FactorsJOURNAL OF GENETICS AND GENOMICS3962472512012
Chen, Yongchang; Niu, Yuyu; Yang, Shihua; He, Xiechao; Ji, Shaohui; Si, Wei; Tang, Xianghui; Xie, Yunhua; Wang, Hong; Lu, Yongqing; Zhou, Qi; Ji, WeizhiThe Available Time Window for Embryo Transfer in the Rhesus Monkey (Macaca mulatta)AMERICAN JOURNAL OF PRIMATOLOGY7421651732012
Wang, Hong; Si, Wei; Niu, Yuyu; Chen, Lixian; Yan, YeUnusual Vesical Calculus in Rhesus Monkey (Macaca mulatta)JOURNAL OF ANIMAL AND VETERINARY ADVANCES1111179017922012
Yang, Shihua; Ping, Shuhuang; Ji, Shaohui; Lu, Yongqing; Niu, Yuyu; Wang, Hong; Ji, Weizhi; Si, WeiThe Positive Effects of Seminal Plasma During the Freezing Process on Cryosurvival of Sperm with Poor Freezability in the Rhesus Macaque (Macaca mulatta)JOURNAL OF REPRODUCTION AND DEVELOPMENT5767377432011
Fu Xianghua; Niu Yuyu; Fan Weise; Wang Yanbo; Wang Xuechao; Gu Xinshun; Jiang YunfaTHE COMPARISON OF EARLY AND ELECTIVE PCI AFTER THROMBOLYSIS REPATENCY WITH RETEPLASE IN STEMI PATIENTSHEART97


2011
Yang, Shihua; Ping, Shuhuang; Si, Wei; He, Xiechao; Wang, Xinyi; Lu, Yongqing; Ji, Shaohui; Niu, Yuyu; Ji, WeizhiOptimization of Ethylene Glycol Concentrations, Freezing Rates and Holding Times in Liquid Nitrogen Vapor for Cryopreservation of Rhesus Macaque (Macaca mulatta) SpermJOURNAL OF VETERINARY MEDICAL SCIENCE7367177232011
Tan, Tao; Tang, Xianghui; Zhang, Jing; Niu, Yuyu; Chen, Hongwei; Li, Bin; Wei, Qiang; Ji, WeizhiGeneration of Trophoblast Stem Cells from Rabbit Embryonic Stem Cells with BMP4PLOS ONE62

2011
Chen, Yongchang; Niu, Yuyu; Ji, Shaohui; He, Xiechao; Tang, Xianghui; Xie, Yunhua; Ji, WeizhiInitiation Timing Cannot Predict Success of Superovulation in Rhesus Monkeys (Macaca mulatta)JOURNAL OF ANIMAL AND VETERINARY ADVANCES1024329332962011
Chen, Yongchang; Ji, Shaohui; Niu, Yuyu; He, Xiechao; Xie, Yunhua; Tang, Xianghui; Ji, WeizhiRecombinant Human Gonadotropins for Rhesus Monkey Superovulation: Age and the Stimulation Interval are Determinant to the FecundityJOURNAL OF ANIMAL AND VETERINARY ADVANCES1024330333072011
Si, Wei; Lu, Yongqing; He, Xiechao; Ji, Shaohui; Niu, Yuyu; Tan, Tao; Ji, WeizhiDirectional freezing as an alternative method for cryopreserving rhesus macaque (Macaca mulatta) spermTHERIOGENOLOGY748143114382010
Niu, Yuyu; Yu, Yang; Bernat, Agnieszka; Yang, Shihua; He, Xiechao; Guo, Xiangyu; Chen, Dongliang; Chen, Yongchang; Ji, Shaohui; Si, Wei; Lv, Yongqin; Tan, Tao; Wei, Qiang; Wang, Hong; Shi, Lei; Guan, Jean; Zhu, Xuemei; Afanassieff, Marielle; Savatier, Pierre; Zhang, Kang; Zhou, Qi; Ji, WeizhiTransgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vectorPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA1074117663176672010
Wang, Yingying; Hai, Tang; Liu, Zichuan; Zhou, Shuya; Lv, Zhuo; Ding, Chenhui; Liu, Lei; Niu, Yuyu; Zhao, Xiaoyang; Tong, Man; Wang, Liu; Jouneau, Alice; Zhang, Xun; Ji, Weizhi; Zhou, QiHSPC117 deficiency in cloned embryos causes placental abnormality and fetal deathBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS39734074122010
Wang, Shufen; Shen, Yi; Yuan, Xiaohua; Chen, Kai; Guo, Xiangyu; Chen, Yongchang; Niu, Yuyu; Li, Jian; Xu, Ren-He; Yan, Xiyun; Zhou, Qi; Ji, WeizhiDissecting Signaling Pathways That Govern Self-renewal of Rabbit Embryonic Stem CellsJOURNAL OF BIOLOGICAL CHEMISTRY2835135929359402008
Niu, Yuyu; Yang, Shihua; Yu, Yang; Ding, Chenhui; Yang, Jifeng; Wang, Shufen; Ji, Shaohui; He, Xiechao; Xie, Yunhua; Tang, Xianghui; Zhou, Qi; Ji, WeizhiImpairments in embryonic genome activation in rhesus monkey somatic cell nuclear transfer embryosCLONING AND STEM CELLS10125352008
Wang, Shufen; Tang, Xianghui; Niu, Yuyu; Chen, Hongwei; Li, Bin; Li, Tianqing; Zhang, Xiuzhen; Hu, Zhixin; Zhou, Qi; Ji, WeizhiGeneration and characterization of rabbit embryonic stem cellsSTEM CELLS2524814892007
Niu, Yuyu; Yang, Shihua; Yang, Jifeng; He, Xiechao; Tang, Xianghui; Xie, Yunhua; Zhou, Qi; Ji, WeizhiMamu-AG transcription in preimplantation embryos derived from SCNT and IVF in rhesus monkey.BIOLOGY OF REPRODUCTION

1641652007
Yang, Jifeng; Yang, Shihua; Beaujean, Nathalie; Niu, Yuyu; He, Xiechao; Xie, Yunhua; Tang, Xianghui; Wang, Liu; Zhou, Qi; Ji, WeizhiEpigenetic marks in cloned rhesus monkey embryos: Comparison with counterparts produced in vitroBIOLOGY OF REPRODUCTION76136422007
Niu, Yuyu; Greube, Alexa; Ji, Weizhi; Jewgenow, KatarinaThe application of in vitro sperm competition test to evaluate the impact of ZP-derived peptides on fertilization capacity of cat spermTHERIOGENOLOGY6649899952006


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