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Trends in Endocrinology & Metabolism述评:果糖通过增强O-GlcNAc糖基化促进肝癌

已有 711 次阅读 2023-12-15 08:36 |系统分类:论文交流

2023年12月13日,Trends in Endocrinology & Metabolism在线发表了题为“Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation”的述评;作者为Emily M. Esquea,Riley G. Young和 Mauricio J. Reginato。

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摘要:High dietary fructose consumption is linked to multiple disease states, including cancer. Zhou and colleagues recently reported a novel mechanism where high dietary fructose levels increase acetate production by the gut microbiome increasing post-translational modification O-GlcNAcylation in liver cells, which contributes to disease progression in mouse models of hepatocellular carcinoma.

关键词:果糖  肝癌  O-GlcNAc糖基化修饰 微生物  乙酸

fructose  liver cancer   O-GlcNAcylation   microbiota   acetate

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Figure 1 Fructose supplementation induces HCC progression via O-GlcNAcylation of eEf1A1 and CAPNS1.

A chemically induced (DEN/CCl4) HCC mouse model fed a high-fructose diet increased progression of liver cancer via microbiota-generated acetate, which is taken up by hepatocytes, possibly via MCT1. Acetate is converted into acetyl-CoA in the mitochondria by the enzyme ACSS1; acetyl-CoA enters the TCA cycle to produce glutamate, which is converted to glutamine by GLUL. Glutamine is used to generate UDP-GlcNAc; this serves as a substrate for OGT to O-GlcNAcylate eEF1A1 and CAPNS1, which drive growth and progression of HCC. Abbreviations: ACSS1, acyl-CoA synthetase short chain family member 1; CAPNS1, calpain small subunit 1; eEF1A1, eukaryotic elongation factor 1A1; GLUL, glutamine synthase; HCC, hepatocellular carcinoma; MCT1, monocarboxylate transporter 1; OGT, O-GlcNAc transferase; TCA, tricarboxylic acid cycle; UDP-GlcNAc, uridine diphospho-N-acetylglucosamine. 

DOIhttps://doi.org/10.1016/j.tem.2023.12.002 

原文链接https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(23)00247-3 



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