重庆医科大学汪凯的科学博客分享 http://blog.sciencenet.cn/u/Kwang02 重医感染性疾病分子生物学教育部重点实验室——汪凯的个人主页

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重庆医科大学汪凯个人简介

已有 3447 次阅读 2021-6-3 09:04 |个人分类:我的日记|系统分类:人物纪事

重庆医科大学汪凯简介(2021年6月更新)

 汪凯,博士,副研究员,硕士生导师。2012年毕业于中国科学院上海巴斯德研究所,获理学博士学位。硕博连读期间主要从事病毒离子通道研究及抗病毒药物筛选;博士后工作期间主要负责传染性疾病分子诊断试剂研发。2015年就职于重庆医科大学,目前主要从事分子病毒学及肝癌代谢研究;围绕代谢与信号转导的交互调控,旨在揭示代谢重编程在肝癌发生发展中的作用,为肝癌治疗提供新的靶点。先后主持2项国家自然科学基金项目;2项重庆市科委及教委课题,1项重庆医科大学“新冠肺炎”应急课题;获国家发明专利1项。在国内外学术期刊发表30余篇论文,其中以第一作者或通讯作者(含共同)在Cell ResearchEMBO JournalJournal of Clinical InvestigationCell Death & DifferentiationClinical Infectious DiseasesSignal Transduct Target Ther.Oncogene等期刊发表SCI论文20余篇,被引用1000余次,谷歌学术h-index16。受邀担任Advanced ScienceGenes & DiseaseClinical and Translational Medicine等学术期刊审稿人。

 

工作经历:

2020.10- 至今    重庆医科大学  感染性疾病分子生物学重点实验室      副研究员

2019.10- 2020.9  重庆医科大学  感染性疾病分子生物学重点实验室      副教授

2015.9 - 2019.9  重庆医科大学  基础医学院    病原生物学教研室      讲师

2013.7 - 2015.7  中国科学院    上海生命科学研究院                  博士后

2012.5 - 2013.5  中科院上海巴斯德研究所 分子病毒与免疫重点实验室   助理研究员

 

研究方向:

(1)分子病毒学;

(2)代谢重编程调控肝癌发生发展的分子机制研究。

  

论文发表:

 

1.  Jin Xiang#, Chang Chen#, Rui Liu#, Dongmei Gou#, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang*, Kai Wang*, Ni Tang*, Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation. Journal of Clinical Investigation2021, 131(8):e144703. (*Co-corresponding author, IF=11.86)

2.  Qiujie Wang#, Bin Cheng#, Qiang Xue#, Qingzhu Gao, Ailong Huang*, Kai Wang*, Ni Tang*, GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell Death & Disease, 2021, 12(5):426. (*Co-corresponding author, IF=6.30

3.  Yi Liu#, Haijun Deng#, Li Liang, Guiji Zhang, Jie Xia, Keyue Ding, Ni Tang*, Kai Wang*Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathwayGenes & Diseases2021, 8(2): 232-240. (*Co-corresponding author)

4.  Chang-Long He#, Lu-Yi Huang#Kai Wang#, Chen-Jian Gu, Jie Hu, Gui-Ji Zhang, Wei Xu, You-Hua Xie*, Ni Tang*, Ai-Long Huang*, Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural productsSignal Transduction and Targeted Therapy2021, doi : 10.1038/s41392-021-00531-5 (#Co-first author, IF=13.49)

5.  Jie Hu# , Pai Peng#, Kai Wang#, Liang Fang, Fei-yang Luo, Ai-shun Jin, Bei-zhong Liu*, Ni Tang*, Ai-long Huang*, Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodiesCellular & Molecular Immunology2021, doi: 10.1038/s41423-021-00648-1 (#Co-first author, IF=8.48)

6.  Pai Peng#, Jie Hu#, Hai-jun Deng, Bei-zhong Liu, Liang Fang, Kai Wang*, Ni Tang*, Ai-long Huang*, Changes of humoral immunity response in SARS-CoV-2 convalescent patients over 8 monthsCellular & Molecular Immunology2021, 18(2), 490–491. (*Co-corresponding author, IF=8.48)

7.  Kai Wang#, Quan-Xin Long#, Hai-Jun Deng#, Jie Hu#, Qing-Zhu Gao, Gui-Ji Zhang, Chang-long He, Lu-Yi Huang, Jie-li Hu, Juan Chen*, Ni Tang*, Ai-Long Huang*, Longitudinal Dynamics of the Neutralizing Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) InfectionClinical Infectious Diseases2020. doi: 10.1093/cid/ciaa1143  (Co-first author, IF=8.31)

8.  Jie Hu#, Qingzhu Gao#, Changlong He, Ailong Huang, Ni Tang*, Kai Wang*Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2Genes & Diseases2020, 7(4):551-557. (*Co-corresponding author)

9.  Jie Hu#, Qingzhu Gao#, Yang Yang#, Jie Xia#, Wanjun Zhang, Yao Chen, Zhi Zhou, Lei Chang, Yuan Hu, Hui Zhou, Li Liang, Xiaosong Li, Quanxin Long, Kai Wang*, Ailong Huang*, Ni Tang*, Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylationTheranostics2021, 11(2):805-823. (*Co-corresponding author, IF=8.58)

10.Qingzhu Gao#, Guiji Zhang#, Yaqiu Zheng#, Yi Yang#, Chang Chen, Jie Xia, Li Liang, Chong Lei, Yuan Hu, Xue-Fei Cai, Wenlu Zhang, Hua Tang, Yaxi Chen, Ailong Huang*, Kai Wang*, Ni Tang*, SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCCCell Death & Differentiation2020, 27(3):1086–1104.  (*Co-corresponding author, IF=10.72)

11.Guiji Zhang#, Xia Tang#, Li Liang#, Wanfeng Zhang, Dewei Li, Xiaoyuan Li, Dachun Zhao, Yaqiu Zheng, Yanhong Chen, Bingtao Hao, Kai Wang*, Ni Tang*, Keyue Ding*DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinomaOncogene2020, 39(16):3229-3244. (*Co-corresponding author, IF=7.97)

12.Jin Xiang#, Yuhong Zhang#, Lin Tuo, Rui Liu, Dongmei Gou, Li Liang, Chang Chen, Jie Xia, Ni Tang, Kai Wang*, Transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma cells detected by RNA-SeqGenes & Diseases2020,7(1):150-159. (Corresponding author)

13.Chong Lei#, Qiujie Wang, Ni Tang*Kai Wang*, GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cellsFEBS Open Bio2020, 10(1):6-17.

14.Jingjing Li#, Qiujie Wang#, Yi Yang, Chong Lei, Fan Yang, Li Liang, Chang Chen, Jie Xia, Kai Wang*, Ni Tang*, GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathwayJournal of Experimental & Clinical Cancer Research2019, 38(1):438.(*Co-corresponding author, IF=7.07)

15.Fan Yang#, Jingjing Li#, Haijun Deng#, Yihao Wang, Chong Lei, Qiujie Wang, Jin Xiang, Li Liang, Jie Xia, Xuanming Pan, Xiaosong Li, Quanxin Long, Lei Chang, Ping Xu, Ailong Huang*, Kai Wang*, Ni Tang*, GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite SuccinylacetoneThe EMBO Journal2019, 38(15):e101964. (*Co-corresponding author, IF=9.89)

16.Xuemei Chen#, Yuan Hu#, Wenlu Zhang, Ke Chen, Jie Hu, Xiaosong Li, Li Liang, Xuefei Cai, Jieli Hu, Kai Wang*, Ailong Huang*, Ni Tang*, Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathwayFree Radical Biology and Medicine2019, 131: 225-236. (*Co-corresponding author, IF=6.17)

17.Lin Tuo#, Jin Xiang#, Xuanming Pan#, Jieli Hu, Hua Tang, Li Liang, Jie Xia, Yuan Hu, Wenlu Zhang, Ailong Huang*, Kai Wang*, Ni Tang*, PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axisJournal of Experimental & Clinical Cancer Research2019, 38(1):50.(*Co-corresponding author, IF=7.07)

18.Lin Tuo#, Jin Xiang#, Xuanming Pan, Qingzhu Gao, Guiji Zhang, Yi Yang, Li Liang, Jie Xia, Kai Wang*, Ni Tang*, PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 PathwayFrontiers in Oncology2018, 8: 611. (*Co-corresponding author, IF=4.85)

19.Qingzhu Gao#Kai Wang#, Ke Chen, Li Liang, Yaqiu Zheng, Yunzhi Zhang, Jin Xiang, Ni Tang *, HBx protein-mediated ATOH1 downregulation suppresses ARID2 expression and promotes hepatocellular carcinomaCancer Science2017, 108(7): 1328-1337. (#Co-first author)

20.Kai Wang#, Wei Lv#, Jianfei Chen#, Shiqi Xie, Hongyan Shi, Haojen Hsu, Wenjing Yu, Ke Xu, Chao Bian, Wolfgang B Fischer, Wolfgang Schwarz, Li Feng*, Bing Sun*, PEDV ORF3 encodes an ion channel protein and regulates virus productionFEBS Letters2012, 586(4):384-391.

21.Kai Wang#, Shiqi Xie, Bing Sun*. Viral proteins function as ion channelsBiochimica et Biophysica Acta (BBA)-Biomembranes2011, 1808(2): 510-515.

22. Shiqi Xie#, Kai Wang#, Wenjing Yu, Wei Lv, Ke Xu, Jianwei Wang, Bin Ye, Wolfgang Schwarz, Qi Jin*, Bing Sun*, DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71Cell Research2011, 21(8): 1271-1275. (#Co-first author)

23.Ronghua Zhang#Kai Wang#, Wei Lv#, Wenjing Yu, Shiqi Xie, Ke Xu, Wolfgang Schwarz, Sidong Xiong*, Bing Sun*, The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral productionBiochimica et Biophysica Acta (BBA)-Biomembranes2014, 1838(4): 1088-1095. (#Co-first author)

24.Ronghua Zhang#Kai Wang, Xianqiang Ping, Wenjing Yu, Zhikang Qian, Sidong Xiong*, Bing Sun*, The ns12. 9 accessory protein of human coronavirus OC43 is a viroporin involved in virion morphogenesis and pathogenesisJournal of Virology2015, 89(22): 11383-11395.

25.Silvia Schwarz#Kai Wang, Wenjing Yu, Bing Sun, Wolfgang Schwarz*, Emodin inhibits current through SARS-associated coronavirus 3a proteinAntiviral Research2011, 90(1): 64-69.

26.Silvia Schwarz#, Daniel Sauter, Kai Wang, Ronghua Zhang, Bing Sun, Anastasia Karioti, Anna Rita Bilia, Thomas Efferth, Wolfgang Schwarz*Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirusPlanta medica2014, 80(02/03): 177-182.

27.Daniel Sauter#, Silvia Schwarz, Kai Wang, Ronghua Zhang, Bing Sun, Wolfgang Schwarz*, Genistein as antiviral drug against HIV ion channelPlanta medica2014, 80(08/09): 682-687.

28. 潘璇明#,张桂冀,陈雪梅,梁利,唐霓,汪凯*果糖-1,6-二磷酸酶1抑制肝癌细胞株HepG2的自噬及增殖. 中华肝脏病杂志2019,27( 9 ): 687-692.

29. 向进#,庹琳,高庆祝,杨翼,梁利,夏杰,唐霓,汪凯*. PCK1影响肝癌细胞迁移能力的研究. 重庆医科大学学报2018, 43(5), 624-628.

30. Yang Yang#, Yu Yan#, Zhen Chen#, Jie Hu, Kai Wang, Ni Tang, Xiaosong Li*, Zhi Zhou*, Histone deacetylase inhibitors romidepsin and vorinostat promote Hepatitis B virus replication by inducing cell cycle arrest. Journal of Clinical and Translational Hepatology, 2021, 9(2):160-168. doi: 10.14218/JCTH.2020.00105 

31. Jie Hu#, Chang-Long He#, Qing-Zhu Gao#, Gui-Ji Zhang#, Xiao-Xia Cao, Quan-Xin Long, Hai-Jun Deng, Lu-Yi Huang, Juan Chen, Kai Wang*, Ni Tang*, Ai-Long Huang*. The D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity. bioRxiv,  2020. doi: 10.1101/2020.06.20.161323

32.   Xiaojian Han#, Yingming Wang#, Shenglong Li#, Chao Hu, Tingting Li, Chenjian Gu, Kai Wang, Meiying Shen, Jianwei Wang, Jie Hu, Ruixin Wu, Song Mu, Fang Gong, Qian Chen, Fengxia Gao, Jingjing Huang, Yingyi Long, Feiyang Luo, Shuyi Song, Shunhua Long, Yanan Hao, Luo Li, Yang Wu, Wei Xu, Xia Cai, Qingzhu Gao, Guiji Zhang, Changlong He, Kun Deng, Li Du, Yaru Nai, Wang Wang, Youhua Xie, Di Qu, Ailong Huang, Ni Tang*, Aishun Jin*, A rapid and efficient screening system for neutralizing antibodies and its application for SARS-CoV-2. Frontiers in Immunology, 2021, 12: 653189. doi: 10.3389/fimmu.2021.653189 



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