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本研究主要是为了证明氢气溶液对放射引起的心脏损伤保护效应的观察,研究发现氢气可显著提高放射后动物生存率,并对放射引起的心脏损伤具有明显的治疗作用,同时能降低心脏氧化损伤,提高抗氧化酶水平。研究结果提示氢气在放射性心脏损伤中具有潜在的临床应用前景。
J Radiat Res (
The potential cardioprotective effects of hydrogen in irradiated mice.
Qian L,
Department of Radiation Medicine, Faculty of Naval Medicine,
Abstract
Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury in mice. In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.
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