声明：本文纯属推测，任何按照本文开展的研究结果是否符合推测本人概不负责。

刚刚阅读到《神经精神药理学》上一篇来自加拿大的文献，该研究表明，与正常人比较，精神分裂患者的脑皮层中氧化型、还原性和总谷胱苷肽均明显降低。过去几年，人们逐渐关注精神疾患与氧化应激的关系，认为抑郁症和精神分裂症都与氧化应激关系密切。本研究采用尸体来源的大脑皮层，研究结果提示人类精神分裂患者与氧化应激可能确实存在很重要的关系。

如果真的这样，应该用氢气也可以对抗精神分裂。这个动物实验就不好作了，不知道有没有这样的动物模型，看来应该找患者试验，但如何征求患者的同意？他们的判断可能有问题。

                                                  

Int J Neuropsychopharmacol. 2010 Jul 16:1-8. [Epub ahead of print]

Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders.

Gawryluk JW, Wang JF, Andreazza AC, Shao L, Young LT.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

Abstract

Accruing data suggest that oxidative stress may be a factor underlying the pathophysiology of bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ). Glutathione (GSH) is the major free radical scavenger in the brain. Diminished GSH levels elevate cellular vulnerability towards oxidative stress; characterized by accumulating reactive oxygen species. The aim of this study was to determine if mood disorders and SCZ are associated with abnormal GSH and its functionally related enzymes. Post-mortem prefrontal cortex from patients with BD, MDD, SCZ, and from non-psychiatric comparison controls were provided by the Stanley Foundation Neuropathology Consortium. Spectrophotometric analysis was utilized for the quantitative determination of GSH, while immunoblotting analyses were used to examine expression of glutamyl-cysteine ligase (GCL), GSH reductase (GR), and GSH peroxidase (GPx). We found that the levels of reduced, oxidized, and total GSH were significantly decreased in all psychiatric conditions compared to the control group. Although GCL and GR levels did not differ between groups, the levels of GPx were reduced in MDD and SCZ compared to control subjects. Since oxidative damage has been demonstrated in MDD, BD, and SCZ, our finding that GSH levels are reduced in post-mortem prefrontal cortex suggests that these patient groups may be more susceptible to oxidative stress.

PMID: 20633320 [PubMed - as supplied by publisher

 

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