研究人员给果蝇喂食抗生素，并监测科学家传统上认为控制衰老的数百个基因的在果蝇一生中的活性。令他们惊讶的是，抗生素不仅延长了苍蝇的寿命，而且还极大地改变了许多这些基因的活性。他们的结果表明，传统上与衰老相关的基因中，只有30%左右的老化基因决定动物的内部生物钟，而其余的基因则反映了身体对细菌的反应。

Scientists may need to rethink which genes control aging, study suggests

Scientists may need to rethink which genes control aging, study suggests: Scientists discover that bacteria may drive activity of many hallmark aging genes in flies -- ScienceDaily

1. Arvind Kumar Shukla, Kory Johnson, Edward Giniger. Common features of aging fail to occur in Drosophila raised without a bacterial microbiome. iScience, 2021; 24 (7): 102703 DOI: 10.1016/j.isci.2021.102703