易鸣分享 http://blog.sciencenet.cn/u/yiming123 对生物网络的建模和模拟以及动力学分析非常感兴趣

博文

酵母命运抉择精确性工作在 Scientific Reports上发表

已有 3789 次阅读 2014-7-4 11:58 |系统分类:论文交流

在酵母命运抉择蛋白调控网络的建模和随机模拟方面的工作被Scientific Reports杂志接收发表。


http://www.nature.com/srep/2014/140721/srep05764/full/srep05764.html


The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast


Abstract
To gain insights into the mechanisms of cell fate decision in a noisy environment, the effects of intrinsic and extrinsic noises on cell fate are explored at the single cell level. Specifically, we theoretically define the impulse of Cln1/2 as an indication of cell fates. The strong dependence between the impulse of Cln1/2 and cell fates is exhibited. Based on the simulation results, we
illustrate that increasing intrinsic fluctuations causes the parallel shift of the separation ratio of
Whi5P but that increasing extrinsic fluctuations leads to the mixture of different cell fates. Our
quantitative study also suggests that the strengths of intrinsic and extrinsic noises around an
approximate linear model can ensure a high accuracy of cell fate selection. Furthermore, this
study demonstrates that the selection of cell fates is an entropy-decreasing process. In addition,
we reveal that cell fates are significantly correlated with the range of entropy decreases.



https://wap.sciencenet.cn/blog-396906-808955.html

上一篇:Spotlight on Quantitative Cell Biology
下一篇:Visualizing an Ultra-Weak Protein–Protein Interaction

2 曾春华 Vetaren11

该博文允许注册用户评论 请点击登录 评论 (3 个评论)

数据加载中...

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2021-8-6 13:01

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部