DAY2

08:30-09:00 K2 Aprediction of degradation of Mg and Mg alloys, why it is not easy?

Wolf-DieterMueller

CharitéUniversitaetsmedizin Berlin

Germany Cor-1

Kinetic of reaction

Mixed potential: depend on the surface size

Galvanic coupling of anodic and cathodic reaction

Random condition: whole wetted area is electrochemicalactive

Random condition: electrochemical reaction can bedescribed.

How can we control the surface during measurement

09:00-09:20 O11Flow-induced corrosion of absorbable magnesium alloy: In-situ and real-timeelectrochemical study

Juan WangSouthwest Jiaotong University

China Cor-2

Localized corrosion may be become a source of stentfracture.

09:20-09:40 O12Degradation morphology and pitting factor compared to degradation rate

Petra MaierUniversity of Applied Sciences Stralsund

Germany Cor-3

Degradation morphology(roughness of surface)

Amount, depth and shape of pits, by pitting factor, ratioof deepest pit P and average penetration d

DRm=8.76X10000Xdeltm/AtP

DRm values do say anything about morphology

Pitting factor increases for as=drawn, a more localdegradation

09:40-10:00 O13Influence of surface condition on the corrosion of XHPMg alloy wire

Sean JohnstonUniversity of Queensland Australia Cor-4

XHP Mg tensile

Iron impurity introduced during cold drawing

10:00-10:20 O14Improvement of corrosion resistance and biocompatibility of WE43 magnesiumalloy treated by titanium and oxygen dual plasma implantation

Zhengjie Lin TheUniversity of Hong Kong

China Cor-5

10:50-11:10 O15Bioactive CaP-coated iron foam for potential bone scaffolds

Hendra HermawanLaval University Canada Cor-6

Porous iron

Coated with CaP

Coated with Ag

11:10-11:30 O16Modulating the degradation behaviour of iron-based biodegradable alloys bygrain sizing and alloying

Agung PurnamaLaval University Canada Cor-7

Elctroforming of iron mini-tube

11:30-11:50 O17The influence of phosphates bicarbonates and chlorides ions on degradationbehavior of pure Fe in pseudophysiological solutions

Ranna ToloueiLaval University Canada Cor-8

HCO3- Cl- HPO4- HPO42-

In vitro 0.2mm/year

In vivo neglectable

NCS Fe3O4

CHBS: pure iron

MHBS: Lepidocrocite

DPBS: beta-FeOOH Fe(H2PO3)22HaO

11:50-12:10 O18Towards standardization: Influence of CO2 rich atmosphere on degradationbehaviour of Fe-Mn-C alloy

Essowé MouzouLaval University Canada Cor-9

12:10-12:30 O19Biodegradation of a novel Zn-Li alloy in abdominal aorta of rat

Shan Zhao MichiganTechnological University

USA Cor-10

Ideally >300MPa to open human artery

Zn-Li, one of only afew potentially age-hardenable Zn-Xbinary alloy system.

Zn-2Li, Zn-4Li, Zn-6Li

Zn-6Li >500MPa elongation <6%

0.25mm wire Zn-4Li 20mm length was punched into abdominalaorta of rat

2, 4, 6.5, 9 and 12months

Degradation ZnCO3 ZnO CaP

Decrease in ductility limits the addition of Li to max.4% if the alloy is considered for the stent application.

Degradation 0.045mm/yeat

16:00-16:30 K3Study of Mg coating fabrication on orthopaedic implants and its biologicalproperties Ke Yang Chinese Academy of Sciences China

16:30-16:35 SOP8Corrosion protection and improved endothelial cytocompatibility of plasmapolymerized allylamine coatings on biodegradable vascular stent

Ying YangSouthwest Jiaotong University China

16:35-16:40 SOP9Preliminary tests to biodegradable metals for ureteral stents

SébastienChampagne Laval University Canada

16:40-16:45 SOP10Effects of zinc on the morphologies and properties of calcium phosphate coatingon magnesium alloys

Jun Wang ZhengzhouUniversity China

16:45-16:50 SOP12Corrosion behavior of T4-treated Mg-5Sn-xZn alloys in simulated body fluid

Chang Dong YimKorea Institute of Materials Science

Korea Invit-5

17:00-17:20 O20 In vitro and in vivo characterizations of zinc alloy coronary stent

Jack Zhou Xi'anAdvanced Medical Technology

China Invit-6

15 Zn stent, 9 stainless steel stent

6 and 10 months

Mild inflammatory response, thin neointimal layer

6month

minor degradation, 1/8 less than original area

MicroCT showed that no significant degradation after 10months

Sevier deformation due to low strength of pure Zn

24 Zn alloy stent,

1M, 3M, 6M, 12M, 24M

3, 3,6,6,6

One month, mild inflammatory response,

Neointimal layer is thin but thicker compared with pureZn stent

Accelerated degradation rate in comparison to pure Zn

No calcification found at month 1

Mild calcification after 3 and 6 month

Degradation interface analysis

Layer I composed of Zn O C

Zn content drops and P/Ca start to appear along thedirection

In vitro (SBF)

Three phases : Zn5(CO3)2(OH)6   ZnO   Zn5(OH)8Cl2.H2O

Mini Pig

36 Zn alloy stent 18 stainless steel stent

1M   3M   6M  12M   36M   72M

6,6,6,6,6,6

OCT at 1,3, and 6 months

Thin neointimal layer

Micro CT at 1 month

Mild degradation and calcification

Possibly that a mixture of n5(CO3)2(OH)6   ZnO and P/Ca compound

17:20-17:25 SOP13Dynamic corrosion behavior of WE43 Mg alloy in a modified simulated body fluidsolution

Mario Alberto AscencioPinedo

McGill UniversityCanada Invit-7

17:25-17:30 SOP14The effect of CO2 or O2 on biocorrosion of Mg alloys Akiko YamamotoNational Institute for Materials Science

Japan Invit-8

17:30-17:35 SOP15Visualization of corrosion initiation of Mg and Mg alloys

Wolf-Dieter MuellerCharité Universitaetsmedizin Berlin

Germany Invit-9

17:35-17:40 SOP16Effects of stent manufacturing on degradation behavior of Fe-basedbiodegradable metals.

Camillus ObayiUniversity of Nigeria Nigeria Invit-10

18:40-19:00 O21Investigating the inhomogeneous degradation of biodegradable metallic stentsthrough in vitro and in silico dynamic testing

Jennifer FrattolinMcGill University Canada Invit-11

Fe-316L biodegradable amalgamate

Cold gas dynamic spraying

0.104mm/year

Abluminal surface, luminal surface

Consideration should be given to the true wetted surfacearea when calculating CRdynamic

19:00-19:20O22 Tailoring the degradation and biological response of a magnesium-strontiumalloy for potential bone substitutes application

PengWan Chinese Academy of Sciences

ChinaInvit-12

19:20-19:40 O23Buffer-induced in vitro corrosion of magnesium alloys:

Considerations forstandardization of in vitro testing

Ryan WilkesUniversity of Canterbury NewZealand Invit-13

19:40-20:00 O24Interactions among Mg substrates rapamycin and poly(lactic-co-glycolic acid)coatings on biodegradable Mg-based drug-eluting stents

Guangyin YuanShanghai Jiao Tong University

China Invit-14