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Crystal Structure of Human free fatty-acid receptor released
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2014-7-24 21:14
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High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875 Nature (2014) doi:10.1038/nature13494 Received 03 October 2013, Accepted 19 May 2014, Published online 20 July 2014 full text Abstract Human GPR40 receptor (hGPR40), also k ...
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个人分类: 科研笔记|2619 次阅读|没有评论
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Another class C GPCR structure released
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2014-7-10 04:37
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Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant Nature (2014) doi:10.1038/nature13396 Received20 January 2014 Accepted22 April 2014 Published online06 July 2014 ...
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个人分类: 科研笔记|2550 次阅读|没有评论
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install NVIDIA Optimus for laptop
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2014-5-23 03:28
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Nowadays, it is quite common and popular to have two dedicated graphic cards in laptop: usually, one is intergrated (eg: intel HD4xxx ) and the other is indepedent (eg: Nvidia GTX xxx). Such strategy can save laptop energy if we use integrated card for document task; while we can switch to inde ...
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个人分类: Linux相关|6958 次阅读|没有评论
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convert multimedia between different formats
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2014-5-5 04:00
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Converting multimedia between different formats can be needed for different purposes. Although there are many tools under Windows, it is still feasible for such task under Linux OS including both command line and GUI end tool. Here are some popular methods for such purposes: ...
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个人分类: Linux相关|3186 次阅读|没有评论
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Hazards Of Functional Groups
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2014-4-18 03:12
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Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. Most of the time in drug discovery are spend in optimizing compound properties including absorption, distribution, metabolism, and excretion (ADME). The four criteria all influence ...
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个人分类: 科研笔记|4989 次阅读|没有评论
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Class C GPCR structure released
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2014-3-17 20:45
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Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator Science DOI: 10.1126/science.1249489 Abstract he excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which &n ...
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2977 次阅读|没有评论
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PyMOL v1.7.0.0 Release Notes
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2014-2-4 23:33
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Release Date: January 14, 2014. Graphics new labels visual additions : connectors, backgrounds, and outlines Note: We are building an interface that will make it easier to control labels interactively so that you won’t need to remember all of these settings explicitly, but th ...
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个人分类: 科研笔记|3605 次阅读|没有评论
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FDA Approves 27 New Drugs in 2013
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2014-2-1 17:12
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The new drug approvals for 2013 were mostly cancer drugs and drugs for orphan diseases. Other therapeutic areas included metabolic and endocrinological therapies (two type 2 diabetes drugs and one dyslipidaemia drug), antivirals (two hepatitis C virus (HCV) drugs and an HIV drug) and medical ima ...
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个人分类: 好文转载|3897 次阅读|没有评论
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