Science Blog of Dr. Yuan分享 This blog is mainly on Molecular molecular modelling and simulations


Another class C GPCR structure released
2014-7-10 04:37
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant Nature (2014) doi:10.1038/nature13396 Received20 January 2014 Accepted22 April 2014 Published online06 July 2014 ...
个人分类: 科研笔记|2320 次阅读|没有评论
install NVIDIA Optimus for laptop
2014-5-23 03:28
Nowadays, it is quite common and popular to have two dedicated graphic cards in laptop: usually, one is intergrated (eg: intel HD4xxx ) and the other is indepedent (eg: Nvidia GTX xxx). Such strategy can save laptop energy if we use integrated card for document task; while we can switch to inde ...
个人分类: Linux相关|6574 次阅读|没有评论
convert multimedia between different formats
2014-5-5 04:00
Converting multimedia between different formats can be needed for different purposes. Although there are many tools under Windows, it is still feasible for such task under Linux OS including both command line and GUI end tool. Here are some popular methods for such purposes: ...
个人分类: Linux相关|2909 次阅读|没有评论
Hazards Of Functional Groups
2014-4-18 03:12
Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. Most of the time in drug discovery are spend in optimizing compound properties including absorption, distribution, metabolism, and excretion (ADME). The four criteria all influence ...
个人分类: 科研笔记|4524 次阅读|没有评论
Class C GPCR structure released
2014-3-17 20:45
Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator Science DOI: 10.1126/science.1249489 Abstract he excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which &n ...
2696 次阅读|没有评论
PyMOL v1.7.0.0 Release Notes
2014-2-4 23:33
Release Date: January 14, 2014. Graphics new labels visual additions : connectors, backgrounds, and outlines Note: We are building an interface that will make it easier to control labels interactively so that you won’t need to remember all of these settings explicitly, but th ...
个人分类: 科研笔记|3298 次阅读|没有评论
FDA Approves 27 New Drugs in 2013
2014-2-1 17:12
The new drug approvals for 2013 were mostly cancer drugs and drugs for orphan diseases. Other therapeutic areas included metabolic and endocrinological therapies (two type 2 diabetes drugs and one dyslipidaemia drug), antivirals (two hepatitis C virus (HCV) drugs and an HIV drug) and medical ima ...
个人分类: 好文转载|3561 次阅读|没有评论
Linux Kernel 3.13 released
2014-1-21 04:09
From : Linux 3.13 Linux 3.13 was released on Sun, 19 Jan 2014. Summary : This release includes nftables, the successor of iptables, a revamp of the block layer designed for high-performance SSDs, a power capping framework to cap power consumption ...
个人分类: Linux相关|4135 次阅读|没有评论

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