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二氧化碳的固定:还原的单羧酸环

已有 5103 次阅读 2007-10-31 11:33 |个人分类:微生物生理学专栏

reductive monocarboxylic acid cycle

 

  

The reduction of CO2 to one-carbon units is essential for the anabolism of Clostridia. In the case of Clostridium kluyveri , CO2 was shown to be the predominant precursor of one-carbon units [ Decker67 , Jungermann68 ]. The process is mediated by two key enzymes. The indirect CO2 reduction via reductive carboxylation of acetyl-CoA to pyruvate is catalyzed by the enzyme pyruvate synthase . The pyruvate is cleaved into acetyl-CoA and formate by the enzyme pyruvate formate-lyase . The formate thus formed enters the anabolic pathways by incorporation into the one-carbon carrier tetrahydrofolate , generating N10-formyl-THF , a reaction catalyzed by formyltetrahydrofolate synthetase [ Thauer70 , Thauer72 ].

It should be noted that while in this pathway pyruvate formate-lyase provides an anabolic function, in other organisms, such as Escherichia coli K-12 , the enzyme has a pure catabolic function in the fermentation of pyruvate to acetate (see pyruvate fermentation to acetate IV ).

以上来自:biocyc.org, 更细节的材料见:http://biocyc.org/META/new-image?type=PATHWAY&object=PWY-5493

原始的文献:

1970年发表的文献:

The synthesis of one-carbon units from CO2 via a new ferredoxin dependent monocarboxylic acid cycle.pdf



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