行,而尚学分享 http://blog.sciencenet.cn/u/dxd 闲话理论生物学

博文

备份 细胞分化与细胞增殖之间是否是相互协调的?

已有 4243 次阅读 2012-5-24 17:53 |系统分类:科研笔记

这是大概一年零两个月之前的某篇。网站上只精确到这个时间。里面的图片也不见了。我自己电脑上可能还有图片备份,抽空再加上。

Inherent coupling between cell differentiation and cycle arrest?

Just finished reading a paper by Gibbs, Liebermann and Hoffman in 2007, "Terminal Myeloid Differentiation is Uncoupled from Cell Cycle Arrest" (DOI:10.4161/cc.6.10.4258). I haven't read any further consequential studies, but I guess they will be very inspiring.

The murine cell line of M1 myeloid can differentiate into macrophage cells when induced with e. g. interleukin-6 (IL-6). During normal process of terminal differentiation, a coupling process of cell cycle arrest occurs.

As revealed in the study,  if a proto-oncogene, c-myc, is manipulated to be overexpressed, the involved cell line will cease from differentiation and go on proliferating without cell cycle arrest. However if another gene, egr-1, is overexpressed meanwhile, the process of differentiation will be restored while cell cycle arrest is still banned by Myc.

The authors' conclusion about the role of Myc is that it banned differentiation "independent of " banning cell cycle arrest. Which could be illustrated as Figure 1.

Figure 1. The senario proposed by the authors.

In such a senario, the inhibition effects of Myc on differentiation and cycle arrest are independent from each other. Egr-1 can & can only prevent the inhibition on cell differentiation by Myc.

However, if we assume there is an inherent coupling between cell cycle arrest and differentiation, then either the left or the right one of the two red arrows in dashed lines should be true.

If the left is true, then we have Figure 2, which can also explain the results in the paper.

Figure 2. An alnernative senario.

In this senario, cell cycle arrest can inherently induce cell differentiation. Under normal condition, IL-6 induces the former and thus consequently induces the latter. Overexpression of Myc can inhibit the former and thus inhibit the latter. However, Egr can & can only restore the latter.

If the right red dashed arrow from Figure 1 is true, then no simple senari can be inferred to be compatible with the  authors' results.

So at this moment it seems that in normal cell lines, it is more likely that cell cycle arrest can lead to cell differentiation, rather than that cell differentiation can lead to cell cycle arrest, provided that the two processes indeed occur with some inherent coupling mechanisms at all.



https://wap.sciencenet.cn/blog-351781-574525.html

上一篇:备份 p32 p53 癌 Warburg effect 癌组织研究中的非线性思维
下一篇:备份 A conception of cancer from a stem-cell viewpoint
收藏 IP: 213.191.250.*| 热度|

0

该博文允许注册用户评论 请点击登录 评论 (0 个评论)

数据加载中...
扫一扫,分享此博文

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2024-4-20 06:18

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部