The statistical analysis of clinical symptoms (the top 10) of 340 discharged patients of COVID-19 shows that the most common clinical symptom was dry cough, with the frequency of 181 times, accounting for 53.24% of the total clinical symptoms. See Table 8 and Figure 9.

When the confidence ≥ 0.82 and support ≥ 0.2 are set, 16 association rules are obtained. See Table 9.

The high frequency herbs (the top 15) in the prescriptions of 340 discharged patients of COVID-19 were analyzed by clustering analysis. The grouping distance >200 was the boundary. According to the clustering analysis results, four categories of commonly used TCM against COVID-19 were identified. Category 1: Radix Codonopsis, Radix Astragali, Rhizoma Pinelliae Preparatum, Poria cocos, and Pericarpium Citri Reticulatae; category 2: Fructus Forsythiae, Rhizoma Atractylodis, and Fructus Tsaoko ; category 3: Radix Glycyrrhizae and Radix Platycodonis; category 4: Radix Scutellariae, Radix Bupleuri, Semen Armeniacae Amarum, Herba Pogostemonis, and Rhizoma Atractylodis Macrocephalae. See Figure 10.

The core drug combination of TCM formula against COVID-19 was extracted with the edge weight >180, and the network map of core drug combination was obtained (Figure 11). The core drug network for treating COVID-19 is composed of Herba Pogostemonis, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae, Rhizoma Atractylodis Macrocephalae​, Rhizoma Atractylodis, Poria cocos, Radix Bupleuri, Radix Scutellariae, Semen Armeniacae Amarum and Radix Glycyrrhizae.

COVID-19 is characterized by fever, dry cough and fatigue. People are generally susceptible, and the disease develops rapidly ^[7]. With the spread of the epidemic, in some regions of China ^[8], the United States ^[9], Japan ^[10] and other countries such cases have also been found. COVID-19 is highly infectious, mainly invading lung ^[11]; multiple organs and tissues of human body can also be involved ^[12]. In serious cases, COVID-19 can lead to multiple organ failure and death. Both children, young adults and the elderly could have disease, with a wide epidemic. Our hospital mainly treated the adult population, and the children patients are not included in statistics. Among patients, 167 were over 60 years old, accounting for 49.12% of all patients. There are many elderly patients in our hospital, which is consistent with the epidemiological characteristics of the onset of COVID-19.

分析武汉市第三医院新型冠状病毒肺炎(COVID-19)患者的中医用药规律,总结疾病特点和临床治疗思路,以期对中医治疗本病有所借鉴。方法:基于古今医案云平台建立数据库,运用频数分析、关联分析、聚类分析、复杂网络等方法,对本院340例出院的COVID-19患者用药规律进行分析。结果:340例COVID-19患者,其中男性143例,女性197例,男∶女=0.73∶1,60岁以上167例,临床患病多以中老人为主,发病时多为干咳、纳差、乏力等表现,治疗新冠肺炎的中药共涉及204味,以茯苓使用频次最高为225次,治疗选用中药以温性、辛甘味及归肺脾经为主,治疗上以清热解毒、祛湿化痰为主,以清肺排毒汤为临床常见方,其核心药由藿香、法半夏、陈皮、白术、苍术、茯苓、柴胡、黄芩、杏仁、甘草组成。结论:本院新冠肺炎患者以中老年人为主,其病因以"寒、湿、毒、疫"为特点,湿邪是疾病发生发展变化最重要的核心。