||
第一作者:Thomas Friedrich
第一单位:德国波茨坦大学
通讯作者:Isabel Bäurle
Abstract
背景回顾:Adaptive plasticity in stress responses is a key element of plant survival strategies. For instance, moderate heat stress (HS) primes a plant to acquire thermotolerance, which allows subsequent survival of more severe HS conditions. Acquired thermotolerance is actively maintained over several days (HS memory) and involves the sustained induction of memory-related genes. 主要研究:Here we show that FORGETTER3/ HEAT SHOCK TRANSCRIPTION FACTOR A3 (FGT3/HSFA3) is specifically required for physiological HS memory and maintaining high memory-gene expression during the days following a HS exposure. 结果1:HSFA3 mediates HS memory by direct transcriptional activation of memory-related genes after return to normal growth temperatures. 结果2:HSFA3 binds HSFA2, and in vivo both proteins form heteromeric complexes with additional HSFs. 结果3:Our results indicate that only complexes containing both HSFA2 and HSFA3 efficiently promote transcriptional memory by positively influencing histone H3 lysine 4 (H3K4) hyper-methylation. 结论:In summary, our work defines the major HSF complex controlling transcriptional memory and elucidates the in vivo dynamics of HSF complexes during somatic stress memory. 摘 要
逆境响应中的适应可塑性是植物生存策略的关键因素。例如,植物在中度热胁迫(heat stress,HS)下可以获得耐热性,从而使得植物能够在更严酷的HS条件下存活。获得性耐热性能够在几天内保持活跃(即HS记忆),其涉及与记忆相关基因的持续诱导。本文中,作者发现FGT3/HSFA3对于植物生理性HS记忆是必须的,该基因会在热胁迫之后的几天内保持较高的基因记忆表达。在植物经历热胁迫并恢复正常生长温度后,HSFA3通过记忆相关基因的直接转录激活介导HS记忆。HSFA3结合HSFA2,并且在体内这两种蛋白与其它的HSFs会形成异聚体。作者的进一步研究结果表明,只有同时含有HSFA2和HSFA3的复合物,才能通过正向调控组蛋白H3K4的高甲基化,从而有效促进转录记忆。总之,本文的工作揭示了一个控制转录记忆的主要HSF复合物,并阐明了体细胞应激记忆过程中HSF复合物的体内动态。
通讯作者
** Isabel Bäurle **
个人简介: 1999-2000年,弗莱堡大学,学士; 2000年,弗莱堡大学,硕士; 2000-2004年,弗莱堡大学,博士。 研究方向:环境胁迫下的转录记忆。
doi: https://doi.org/10.1038/s41467-021-23786-6
Journal: Nature Communications
Published date: June 08, 2021
Archiver|手机版|科学网 ( 京ICP备07017567号-12 )
GMT+8, 2024-4-25 14:35
Powered by ScienceNet.cn
Copyright © 2007- 中国科学报社