药效团(pharmacophore)是配体被生物大分子进行分子识别所必需的物理化学特征及其空间排布。国际纯粹化学与应用化学联合会(IUPAC)对药效团的定义是“an ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biologi ...
在1999年拉斯克临床医学奖得主David Cushman和Miguel Ondetti网页上发现下面的文字: A seminar in 1968 by Sir John Vane, a scientific consultant to Squibb, was the seminal event that led to the Cushman-Ondetti collaboration. Vane, who directed a laboratory at the Royal College o ...