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科学疯子、医学狂人----卡纳维洛

已有 2402 次阅读 2015-4-19 04:19 |个人分类:外科移植|系统分类:观点评述

 

综述分析博文,不许转载。

头移植”不科学

意大利外科医生塞尔吉奥·卡纳维洛最早将于明年为一名30岁俄罗斯男子志愿者实施“换头术”。

任晓平在发表于《中枢神经系统神经科学与治疗》(《CNS Neuroscience & Therapeutics》)的文章《异体头身重建的概念、挑战和机遇》中提出“异体头身重建”这一概念。“异体”与“头身”容易理解,“重建”借鉴于临床医学的称谓,意在重建一个“新人”。


Allogeneic head and body reconstruction: mouse model.
Journal: CNS neuroscience & therapeutics (Cns Neurosci Ther), Vol. 20 (12): 1056-60, 2014 .
AIMS: There is still no effective way to save a surviving healthy mind when there is critical organ failure in the body. The next frontier in CTA is allo-head and body reconstruction (AHBR), and just as animal models were key in the development of CTA, they will be crucial in establishing theprocedures of AHBR for clinical translation. METHODS AND RESULTS: Our approach, pioneered in mice, involves retaining the donor brain stem and transplanting the recipient head. Our preliminary data in mice support that this allows for retention of breathing and circulatory function. Critical aspects of the current protocol include avoiding cerebral ischemia through cross-circulation (donor to recipient) and retaining the donor brain stem. Successful clinical translation of AHBR will become a milestone of medical history and potentially could save millions of people. CONCLUSIONS: This experimental study has confirmed a method to avoid cerebral ischemiaduring the surgery and solved an important part of the problem of how to accomplish long-termsurvival after transplantation and preservation of the donor brain stem.
Affiliation: Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China; State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China; Department of Molecular Pharmacology & Therapeutics, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, USA..
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HEAVEN: The head anastomosis venture Project outline for the first human head transplantation with spinal linkage (GEMINI).
意大利外科医生塞尔吉奥·卡纳维洛最早将于明年为一名30岁俄罗斯男子志愿者实施“换头术”。
Journal: Surgical neurology international (Surg Neurol Int), Vol. 4 (Suppl 1): S335-42, 2013 .
In 1970, the first cephalosomatic linkage was achieved in the monkey. However, the technologydid not exist for reconnecting the spinal cord, and this line of research was no longer pursued. In this paper, an outline for the first total cephalic exchange in man is provided and spinal reconnection is described. The use of fusogens, special membrane-fusion substances, is discussed in view of the first human cord linkage. Several human diseases without cure might benefit from the procedure.
Affiliation: Turin Advanced Neuromodulation Group, Turin, Italy. .
Protein: GEMINI .
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大脑图示

俄罗斯志愿者斯皮里多诺夫


 

 
 
 
4月16日科技日报刊发的《全球首例头部移植手术志愿者现身》的报道中,提到意大利外科医生塞尔吉奥·卡纳维洛最早将于明年为一名30岁俄罗斯男子志愿者实施“换头术”。16日下午,科技日报记者就此采访了从事“异体复合组织移植”研究的哈尔滨医科大学附属第二医院手足显微外科教授任晓平。
 
任晓平告诉记者,他和卡纳维洛已经分别收到今年6月将在美国举行的第39届神经学和骨科年会的正式邀请,将在会上做主题发言,围绕为“异体头身重建临床前动物模型设计及实验研究”做大会分享。“卡纳维洛将手术命名为‘HEAVEN’,我给他翻译为‘天堂手术’。”
 
“头移植”称谓不科学

 

http://news.sciencenet.cn/htmlnews/2015/4/317201.shtm 

国际研究论文分析如下

 

Top Years
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1998
 
2
2014
 
1
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1
2011
 
1
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1999
 
1
1991
 
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1
1962
 
1
1959
 
1
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Surg Neurol Int
 
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1
Exp Parasitol
 
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J Heart Lung Transpl
 
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Int Orthop
 
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Gonzalez M
 
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Yajima H
 
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publications over timepublications over timeworld mapnetwork of top authorsnetwork of top authors
network of top authors-Legend

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Allogeneic head and body reconstruction: mouse model.
Authors: Ren, Xiao-Ping, et.al. .
Journal: CNS neuroscience & therapeutics (Cns Neurosci Ther), Vol. 20 (12): 1056-60, 2014 .
CONCLUSIONS: This experimental study has confirmed a method to avoid cerebral ischemiaduring the surgery and solved an important part of the problem of how to accomplish long-termsurvival after transplantation and preservation of the donor brain stem.
Affiliation: Hand and Microsurgical Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China; State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China; Department of Molecular Pharmacology & Therapeutics, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, USA..
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HEAVEN: The head anastomosis venture Project outline for the first human head transplantation with spinal linkage (GEMINI).
Journal: Surgical neurology international (Surg Neurol Int), Vol. 4 (Suppl 1): S335-42, 2013 .
However, the technology did not exist for reconnecting the spinal cord, and this line of research was no longer pursued.
Affiliation: Turin Advanced Neuromodulation Group, Turin, Italy. .
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Vladimir P. Demikhov, a pioneer of organ transplantation.
Authors: Langer, R M .
Journal: Transplantation proceedings (Transplant Proc), Vol. 43 (4): 1221-2, 2011 .
In 1954 he performed a head transplantation, for which he gained worldwide infamy.
Affiliation: Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary. roblanger@hotmail.com.
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Tissue-engineered approach for the treatment of steroid-induced osteonecrosis of the femoral head: transplantation ofautologous mesenchymal stem cells cultured with beta-tricalcium phosphate ceramics and free vascularized fibula.
Authors: Kawate, Kenji, et.al. .
Journal: Artificial organs (Artif Organs), Vol. 30 (12): 960-2, 2006 .
Autologous mesenchymal stem cells (MSCs) cultured with beta-tricalcium phosphate (beta-TCP)ceramics and with a free vascularized fibula were transplanted into three patients with steroid-induced osteonecrosis of the femoral head.
Affiliation: Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Nara, Japan. kkawate@naramed-u.ac.jp.
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Role of the head in the ultrastructural midgut organization inRhodnius prolixus larvae: evidence from head transplantationexperiments and ecdysone therapy.
Authors: Garcia, E S., et.al. .
Journal: Journal of insect physiology (J Insect Physiol), Vol. 44 (7-8): 553-560, 1998 .
Studies on the effects of decapitation, head transplantation and ecdysone therapy on the ultrastructural organization of the midgut in 5th-instar larvae of Rhodnius prolixus, were carried out.
Affiliation: Department of Biochemistry and Molecular Biology, Fundação Oswaldo Cruz, Av. Brasil 4365, Castel Mourisco-5o Andar, Manguinhos, CEP 21045-900, Rio de Janeiro, Brazil.
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[Head transplantation?].
Authors: Heinzl, S .
Journal: Medizinische Monatsschrift für Pharmazeuten (Med Monatsschr Pharm), Vol. 24 (5): 141, 2001.
No Abstract available.
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Influence of brain and azadirachtin on Trypanosoma cruzidevelopment in the vector, Rhodnius prolixus.
Authors: Gonzalez, M S, et.al. .
Journal: Experimental parasitology (Exp Parasitol), Vol. 92 (2): 100-8, 1999 .
Studies on the effects of decapitation, head transplantation, azadirachtin, and ecdysonetherapy on the ultrastructural organization of the midgut of Rhodnius prolixus, a vector of the protozoan Trypanosoma cruzi, show a distinct effect on the organization of the epithelial cells.
Affiliation: Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense, Morro do Valonguinho SIN degrees, Niterói, RJ, CEP 24001-970, Brazil..
Antibodies OnlineForkhead Box G1 (FOXG1) .
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Treatment of humoral rejection after heart transplantation.
Authors: Grauhan, O, et.al. .
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (J Heart Lung Transpl), Vol. 17 (12): 1184-94, 1998.
CONCLUSIONS: By diluting inflammatory mediators, apheresis leads to a rapid improvement in cardiac function during severe humoral rejection after head transplantation.
Affiliation: Department of Cardiothoracic and Vascular Surgery, German Heart Institute, Berlin. .
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Vertebral body replacement with homologous femoral head transplants.
Authors: Griss, P, et.al. .
Journal: International orthopaedics (Int Orthop), Vol. 15 (1): 65-9, 1991 .
From 1978 to 1989, we carried out 15 resections of single vertebral bodies, with homologous femoral head transplantation, for malignant and benign lesions of the spine.
Affiliation: Department for Orthopaedic Surgery, Phillips University, Marburg, Federal Republic of Germany..
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[TREATMENT OF FEMORAL NECK FRACTURES (FEMUR HEADTRANSPLANTATION INTO THE GREAT TROCHANTER)].
Authors: WATANABE, K, et.al. .
Journal: Nihon Seikeigeka Gakkai zasshi (Nippon Seikeigeka Gakkai Zasshi), Vol. 38, 1964 .
No Abstract available.
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Fate of osteochondral grafts.
Authors: DEPALMA, A F, et.al. .
Journal: Clinical orthopaedics (Clin Orthop), Vol. 22, 1962 .
No Abstract available.
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[Organ transplantations; report on heart & head grafts performed by W. Demichov, Moscow].
Authors: UEBERMUTH, H .
Journal: Münchener medizinische Wochenschrift (1950) (Munch Med Wochenschr), Vol. 101 (13): 529-31, 1959.
No Abstract available.

 


 



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