博文
胆固醇和癌症的关联性研究进展与知识发现
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Breast Cancer Res.：有益胆固醇或增加乳腺癌发病风险
高密度脂蛋白（high density lipoprotein，HDL）被认为是一种"有益胆固醇"，高水平的HDL能够预防心脏病产生。然而常言道"甲之熊掌，乙之砒霜"，动物实验表明高水平的HDL也会增加乳腺癌发病风险，增加癌症恶性程度。
托马斯杰斐逊大学生化和分子生物学系Philippe Frank博士领导的研究人员发现乳腺癌细胞表明的HDL受体对乳腺癌发病有重要作用，该分子或为治疗乳腺癌的新靶点。相关报道发表在近期的Breast Cancer Research杂志上。
为了研究HDL在分子水平对癌细胞的影响，Frank博士领导的科学家在培养的乳腺癌细胞系中加入HDL，观察癌细胞的变化发现癌细胞开始转移。
http://www.bioon.com/tm/others/584898.shtml
检索策略 high density lipoprotein and Breast Cancer
信息平台 http://www.pubmedplus.cn/Pubmed/Statistic
分析结果
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| A-query: Breast Cance C-query: high density lipoprotein The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 0 articles appeared in both literatures. The results of this search are saved under id # 28992 and can be accessed from the start page after you leave this session. There are 315 terms on the current B-list (60 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. |
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=28992
id # 28992 started Fri Oct 25 23:00:47 2013
Max_citations: 50000
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A_query_raw: Breast CanceFri Oct 25 23:00:52 2013
A query = Breast Cance started Fri Oct 25 23:00:52 2013
A query resulted in 47 titles
C_query_raw: Breast Cance Fri Oct 25 23:00:56 2013
C: Breast Cancer 47
A: pubmed_query_A 47
AC: ( Breast Cance ) AND ( Breast Cance ) 47
C_query_raw: high density lipoprotein Fri Oct 25 23:01:07 2013
C: high density lipoprotein 64776
A: pubmed_query_A 47
AC: ( Breast Cance ) AND ( high density lipoprotein ) 0
C_query_raw: high density lipoprotein Fri Oct 25 23:01:09 2013
C: high density lipoprotein 64776
A: pubmed_query_A 47
AC: ( Breast Cance ) AND ( high density lipoprotein ) 0
C query = high density lipoprotein started Fri Oct 25 23:01:09 2013
C query resulted in 50000 titles
A AND C query resulted in 0 titles
315 B-terms ready on Fri Oct 25 23:01:20 2013
B-list on Fri Oct 25 23:31:04 2013
1 neoadjuvant
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30 mcf-7 breast cancer
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34 breast disease
35 protein kinase
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44 egfr
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