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研究热点与前沿：成人神经干细胞对于成年神经再生的重要意义
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利用汤森路透科技集团的基本科学指标库（Essential Science Indicators）2004－2010间的高被引论文及其同被引聚类分析，通过同被引而密切关联的相关论文聚类形成若干个科学研究领域，由此绘制科学文献所反映的科学研究结构地图，讨论科学发展的基本格局。通过研究和揭示科学结构及其演化，为各领域研究提供一种思考问题、发现潜在交叉学科、“热点”领域。
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第一部分：RA 4 的基本信息
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RA ID: 4 | |||||
RA的名称 | 成人神经干细胞对于成年神经再生的重要意义 | ||||
RA的关键词 | neural stem cells; in the; in the adult; adult neurogenesis; stem cells; hippocampal neurogenesis; neural stem; adult hippocampal neurogenesis; adult hippocampal; the adult | ||||
包含RF数(Hot RF数) | 核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | |
7(5) | 60 | 2702 | 5495 | 2006.9 | |
该RA中包含RF的图谱 | |||||
成年神经再生的调控机制、功能性意义以及对病理学的贡献 | |||||
RA概述 | |||||
神经干细胞(neural stem cell，NSC)是近期神经生物科学领域和脑科学领域的热点，目前主要分为胚胎神经干细胞和成人神经干细胞两大领域。其中成人神经干细胞代表了最近十年最惊人的发现之一。它为神经干细胞的应用提供了更为广阔的前景。相当长时间以来，人们认为成年大脑的再生能力非常有限。现在研究发现神经再生是成年哺乳动物中枢神经系统中普遍存在的现象，妊娠也可以影响成年神经细胞再生。在成年大脑中存在着神经干细胞聚焦区，这些成人神经干细胞对于成年神经再生具有重要意义。由成人神经干细胞生成的新生神经元具有电生理功能，不仅能够对损伤的大脑进行修复，而且可能参与记忆和学习等高级神经功能。目前已有成人神经干细胞自体移植治疗脑损伤的初步临床研究。 | |||||
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第二部分：RA 4 包含的7个RF的基本信息
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RF ID: 7550 | ||||
核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
40 | 1391 | 3544 | 2007.2 | No |
RF的关键词 | spatial relational memory; hippocampal adult neurogenesis; adult hippocampal neurogenesis; failing adult hippocampal neurogenesis; adult neurogenesis; adult dentate gyrus form functional synapses | |||
RF ID: 9825 | ||||
核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
6 | 121 | 287 | 2008.3 | Yes |
RF的关键词 | periventricular neural stem cells; adult neural stem cells; neural stem cells confer unique pinwheel architecture; adult svz stem cells lie; cd133(+) neural stem cells | |||
RF ID: 12449 | ||||
核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
4 | 628 | 866 | 2004.2 | No |
RF的关键词 | radial glia serve; adult neural stem cells; adult dentate gyrus; adult mouse forebrain; germinal zone | |||
RF ID: 6811 | ||||
核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
4 | 381 | 527 | 2006.0 | Yes |
RF的关键词 | adult olfactory bulb neurogenesis neuronal fate determinants; neural stem cells; adult brain; adult svz; pdgfr alpha-positive b cells | |||
RF ID: 13516 | ||||
核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
2 | 490 | 623 | 2005.5 | Yes |
RF的关键词 | adult neurogenesis; mammalian central nervous system; functional plasticity; neuronal circuits | |||
RF ID: 15285 | ||||
核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
2 | 204 | 251 | 2006.0 | Yes |
RF的关键词 | hippocampal neurogenesis stress-antidepressant treatment opposing effects; regulation | |||
RF ID: 11796 | ||||
核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
2 | 327 | 393 | 2005.0 | Yes |
RF的关键词 | wnt signalling regulates adult hippocampal neurogenesis; quiescent adult neural stem cell sonic hedgehog response invivo analysis | |||
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第三部分：7个RF的核心论文详细列表
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RF ID | 核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
7550 | 40 | 1391 | 3544 | 2007.2 | No |
RF的关键词 | spatial relational memory; hippocampal adult neurogenesis; adult hippocampal neurogenesis; failing adult hippocampal neurogenesis; adult neurogenesis; adult dentate gyrus form functional synapses | ||||
论文题目 | 被引 | 年份 | 刊名 | 第一作者 | 第一机构、国家 |
mechanisms and functional implications of adult neurogenesis | 253 | 2008 | CELL | ZHAO CM | Salk Inst Biol Studies, USA |
enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus | 250 | 2004 | NATURE | SCHMIDT-HIEBER C | Univ Freiburg, Germany |
gaba regulates synaptic integration of newly generated neurons in the adult brain | 217 | 2006 | NATURE | GE SY | Johns Hopkins Univ, USA |
a role for adult neurogenesis in spatial long-term memory | 181 | 2005 | NEUROSCIENCE | SNYDER JS | Univ Toronto, Canada |
excitation-neurogenesis coupling in adult neural stem/progenitor cells | 181 | 2004 | NEURON | DEISSEROTH K | Stanford Univ, USA |
gabaergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells | 172 | 2005 | NEURON | TOZUKA Y | Univ Tokyo, Japan |
distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus | 168 | 2006 | J NEUROSCI | ZHAO CM | Salk Inst Biol Studies, USA |
brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus | 167 | 2005 | J NEUROSCI | SAIRANEN M | Univ Helsinki, Finland |
potential role for adult neurogenesis in the encoding of time in new memories | 162 | 2006 | NAT NEUROSCI | AIMONE JB | Salk Inst Biol Studies, USA |
is there a link between adult neurogenesis and learning? | 147 | 2006 | HIPPOCAMPUS | LEUNER B | Rutgers State Univ, USA |
ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus | 128 | 2006 | PROC NAT ACAD SCI USA | SAXE MD | Columbia Univ, USA |
preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus | 120 | 2007 | NAT NEUROSCI | KEE N | Hosp Sick Children, Canada |
inhibition of neurogenesis interferes with hippocampus-dependent memory function | 116 | 2006 | HIPPOCAMPUS | WINOCUR G | Baycrest Ctr Geriatr Care, Canada |
hippocampal neurogenesis is not required for behavioral effects of environmental enrichment | 116 | 2006 | NAT NEUROSCI | MESHI D | Columbia Univ, USA |
nmda-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus | 108 | 2006 | NATURE | TASHIRO A | Salk Inst Biol Studies, USA |
adult hippocampal neurogenesis in depression | 100 | 2007 | NAT NEUROSCI | SAHAY A | Columbia Univ, USA |
a critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain | 86 | 2007 | NEURON | GE SY | Johns Hopkins Univ, USA |
synapse formation on neurons born in the adult hippocampus | 79 | 2007 | NAT NEUROSCI | TONI N | Salk Inst Biol Studies, USA |
gaba sets the tempo for activity-dependent adult neurogenesis | 69 | 2007 | TRENDS NEUROSCI | GE SY | Johns Hopkins Univ, USA |
a role for adult tlx-positive neural stem cells in learning and behaviour | 69 | 2008 | NATURE | ZHANG CL | Salk Inst Biol Studies, USA |
experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage | 64 | 2007 | J NEUROSCI | TASHIRO A | 10010 N Torrey Pines Rd, USA |
neurons born in the adult dentate gyrus form functional synapses with target cells | 60 | 2008 | NAT NEUROSCI | TONI N | Salk Inst Biol Studies, USA |
roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain | 60 | 2008 | NAT NEUROSCI | IMAYOSHI I | Kyoto Univ, Japan |
in vivo fate analysis reveals the multipotent and self-renewal capacities of sox2(+) neural stem cells in the adult hippocampus | 59 | 2007 | CELL STEM CELL | SUH H | Salk Inst Biol Studies, USA |
behavioral effects of chronic fluoxetine in balb/cj mice do not require adult hippocampal neurogenesis or the serotonin 1a receptor | 58 | 2008 | NEUROPSYCHOPHARMACOLOGY | HOLICK KA | Columbia Univ, USA |
ketamine-induced neuronal cell death in the perinatal rhesus monkey | 49 | 2007 | TOXICOL SCI | SLIKKER W | US FDA, USA |
chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells | 41 | 2008 | J NEUROSCI | WANG JW | Columbia Univ, USA |
early exposure to anesthesia and learning disabilities in a population-based birth cohort | 37 | 2009 | ANESTHESIOLOGY | WILDER RT | Mayo Clin, USA |
isoflurane-induced neuroapoptosis in the developing brain of nonhypoglycemic mice | 32 | 2008 | J NEUROSURG ANESTHESIOL | JOHNSON SA | Washington Univ, USA |
the contribution of failing adult hippocampal neurogenesis to psychiatric disorders | 27 | 2008 | CURR OPIN PSYCHIATRY | KEMPERMANN G | Tech Univ Dresden, Germany |
dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats | 21 | 2009 | LEARN MEMORY | JESSBERGER S | Salk Inst Biol Studies, USA |
spatial relational memory requires hippocampal adult neurogenesis | 20 | 2008 | PLOS ONE | DUPRET D | Inst F Magendie, France |
a functional role for adult hippocampal neurogenesis in spatial pattern separation | 20 | 2009 | SCIENCE | CLELLAND CD | Salk Inst Biol Studies, USA |
computational influence of adult neurogenesis on memory encoding | 19 | 2009 | NEURON | AIMONE JB | Salk Inst Biol Studies, USA |
neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression | 19 | 2009 | NEURON | DAVID DJ | Univ Paris Sud, France |
behavior and development in children and age at the time of first anesthetic exposure | 16 | 2009 | ANESTHESIOLOGY | KALKMAN CJ | Univ Med Ctr Utrecht, Netherlands |
inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system | 15 | 2009 | ANESTHESIOLOGY | HEAD BP | Univ Calif San Diego, USA |
adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology | 14 | 2009 | NEUROSCI BIOBEHAV REV | BALU DT | Univ Penn, USA |
effect of hypercarbia and isoflurane on brain cell death and neurocognitive dysfunction in 7-day-old rats | 12 | 2009 | ANESTHESIOLOGY | STRATMANN G | Univ Calif San Francisco, USA |
isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats | 12 | 2009 | ANESTHESIOLOGY | STRATMANN G | Univ Calif San Francisco, USA |
RF ID | 核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
9825 | 6 | 121 | 287 | 2008.3 | Yes |
RF的关键词 | periventricular neural stem cells; adult neural stem cells; neural stem cells confer unique pinwheel architecture; adult svz stem cells lie; cd133(+) neural stem cells | ||||
论文题目 | 被引 | 年份 | 刊名 | 第一作者 | 第一机构、国家 |
a specialized vascular niche for adult neural stem cells | 74 | 2008 | CELL STEM CELL | TAVAZOIE M | Columbia Univ, USA |
adult svz stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions | 65 | 2008 | CELL STEM CELL | SHEN Q | New York Neural Stem Cell Inst, USA |
neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain | 51 | 2008 | CELL STEM CELL | MIRZADEH Z | Univ Calif San Francisco, USA |
cd133(+) neural stem cells in the ependyma of mammalian postnatal forebrain | 46 | 2008 | PROC NAT ACAD SCI USA | COSKUN V | Univ Calif Los Angeles, USA |
forebrain ependymal cells are notch-dependent and generate neuroblasts and astrocytes after stroke | 31 | 2009 | NAT NEUROSCI | CARLEN M | Karolinska Inst, Sweden |
identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both? | 20 | 2009 | NAT REV NEUROSCI | CHOJNACKI AK | Univ Calgary, Canada |
RF ID | 核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
12449 | 4 | 628 | 866 | 2004.2 | No |
RF的关键词 | radial glia serve; adult neural stem cells; adult dentate gyrus; adult mouse forebrain; germinal zone | ||||
论文题目 | 被引 | 年份 | 刊名 | 第一作者 | 第一机构、国家 |
gfap-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain | 238 | 2004 | NAT NEUROSCI | DENISE A | Univ Calif Los Angeles, USA |
radial glia serve as neuronal progenitors in all regions of the central nervous system | 233 | 2004 | NEURON | ANTHONY TE | Rockefeller Univ, USA |
radial glia give rise to adult neural stem cells in the subventricular zone | 219 | 2004 | PROC NAT ACAD SCI USA | MERKLE FT | Univ Calif San Francisco, USA |
cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus | 176 | 2004 | J COMP NEUROL | SERI B | Univ Calif San Francisco, USA |
RF ID | 核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
6811 | 4 | 381 | 527 | 2006.0 | Yes |
RF的关键词 | adult olfactory bulb neurogenesis neuronal fate determinants; neural stem cells; adult brain; adult svz; pdgfr alpha-positive b cells | ||||
论文题目 | 被引 | 年份 | 刊名 | 第一作者 | 第一机构、国家 |
neuronal fate determinants of adult olfactory bulb neurogenesis | 181 | 2005 | NAT NEUROSCI | HACK MA | GSF, Germany |
origin of oligodendrocytes in the subventricular zone of the adult brain | 121 | 2006 | J NEUROSCI | MENN B | Univ Calif San Francisco, USA |
mosaic organization of neural stem cells in the adult brain | 115 | 2007 | SCIENCE | MERKLE FT | Univ Calif San Francisco, USA |
pdgfr alpha-positive b cells are neural stem cells in the adult svz that form glioma-like growths in response to increased pdgf signaling | 110 | 2006 | NEURON | JACKSON EL | Univ Calif San Francisco, USA |
RF ID | 核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
13516 | 2 | 490 | 623 | 2005.5 | Yes |
RF的关键词 | adult neurogenesis; mammalian central nervous system; functional plasticity; neuronal circuits | ||||
论文题目 | 被引 | 年份 | 刊名 | 第一作者 | 第一机构、国家 |
adult neurogenesis in the mammalian central nervous system | 359 | 2005 | ANNU REV NEUROSCI | MING GL | Johns Hopkins Univ, USA |
adult neurogenesis and functional plasticity in neuronal circuits | 264 | 2006 | NAT REV NEUROSCI | LLEDO PM | Inst Pasteur, France |
RF ID | 核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
15285 | 2 | 204 | 251 | 2006.0 | Yes |
RF的关键词 | hippocampal neurogenesis stress-antidepressant treatment opposing effects; regulation | ||||
论文题目 | 被引 | 年份 | 刊名 | 第一作者 | 第一机构、国家 |
hippocampal neurogenesis: opposing effects of stress and antidepressant treatment | 130 | 2006 | HIPPOCAMPUS | WARNER-SCHMIDT JL | 34 Pk St, USA |
hippocampal neurogenesis: regulation by stress and antidepressants | 121 | 2006 | BIOL PSYCHIAT | DRANOVSKY A | Columbia Univ, USA |
RF ID | 核心论文数 | 被引用篇数 | 总被引次数 | 平均出版年 | 是否为热点 |
11796 | 2 | 327 | 393 | 2005.0 | Yes |
RF的关键词 | wnt signalling regulates adult hippocampal neurogenesis; quiescent adult neural stem cell sonic hedgehog response invivo analysis | ||||
论文题目 | 被引 | 年份 | 刊名 | 第一作者 | 第一机构、国家 |
wnt signalling regulates adult hippocampal neurogenesis | 242 | 2005 | NATURE | LIE DC | Salk Inst Biol Studies, USA |
in vivo analysis of quiescent adult neural stem cells responding to sonic hedgehog | 151 | 2005 | NATURE | AHN S | NICHHD, USA |
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