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呼肠孤病毒治疗癌症的知识发现

已有 3802 次阅读 2012-6-15 11:01 |个人分类:知识发现|系统分类:论文交流| 知识, 病毒, 治疗

知识发现平台修好了,可以用了。
对科研选题、科研参考都很有意义。
大家多用,熟能生巧,巧能生华。
 
 
Start A-Literature C-Literature B-list Filter Literature
A-query: Reovirus
C-query: cancer and therapy

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 132 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 7146 and can be accessed from the start page after you leave this session. There are 5291 terms on the current B-list (903 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi?refresh=T&ID=7146

 

job id # 7146 started Thu Jun 14 21:56:30 2012
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: ReovirusThu Jun 14 21:56:36 2012

A query = Reovirus started Thu Jun 14 21:56:36 2012
A query resulted in 2905 titles
C_query_raw: Reovirus Thu Jun 14 21:56:39 2012

C: Reovirus 2905

A: pubmed_query_A 2905

AC: ( Reovirus ) AND ( Reovirus ) 2905

C_query_raw: cancer and therapy Thu Jun 14 21:57:22 2012

C: cancer and therapy 1211456

A: pubmed_query_A 2905

AC: ( Reovirus ) AND ( cancer and therapy ) 132

C_query_raw: cancer and therapy Thu Jun 14 21:57:25 2012

C: cancer and therapy 1211456

A: pubmed_query_A 2905

AC: ( Reovirus ) AND ( cancer and therapy ) 132

C query = cancer and therapy started Thu Jun 14 21:57:26 2012
C query resulted in 50000 titles
A AND C query resulted in 132 titles
5291 B-terms ready on Thu Jun 14 21:58:28 2012

B-list on Thu Jun 14 22:00:12 2012
1 akt
2 rotavirus
3 proteomic
4 stat3
5 expression analysis
6 toll receptor
7 jnk
8 jak stat
9 bcl-2
10 rna interference
11 nf kappab
12 ribavirin
13 kappab
14 oncolytic virotherapy
15 capsid protein
16 sequencing
17 parvovirus
18 p38
19 induce apoptosis
20 caspase
21 induced apoptosis
22 related apoptosis inducing
23 rna silencing
24 pancreas
25 human immunodeficiency virus
26 inflammatory cytokine
27 activated protein kinase
28 nuclear factor
29 cancer stem
30 cancer stem cell
31 proteasome inhibition
32 marek disease
33 mapk
34 lymphokine activated killer
35 p38 mapk
36 p53-dependent
37 cloning
38 smac diablo
39 ribozyme
40 p38 mitogen activated
41 cd4
42 signaling pathway
43 proteasome
44 regulatory t cell
45 p53
46 zinc finger
47 activated killer
48 fas fas ligand
49 c jun
50 pcr detection
51 cyclosporine
52 oncolytic
53 anti idiotype
54 il-12
55 trail
56 3-kinase akt
57 metapneumovirus
58 molecular dynamic
59 factor related apoptosis
60 jak
61 proteomic analysis
62 human immunodeficiency
63 growth factor receptor
64 t cell mediated
65 apoptosis inducing ligand
66 encoding
67 myxoma
68 expression vector
69 cytotoxic t
70 caspase dependent
71 baculovirus
72 sclerosing cholangitis
73 epidermal growth factor
74 fusion peptide
75 gp130
76 inducing ligand
77 pcr assay
78 helicobacter
79 pcr
80 apoptotic
81 cytokine
82 mitogen activated protein
83 translational
84 marek
85 resistant gastric cancer
86 primary sclerosing cholangitis
87 fluoroquinolone
88 taqman
89 related apoptosis
90 design synthesis
91 choledochal cyst
92 cd4 cd8
93 avian influenza
94 toll receptor signaling
95 temperature sensitive
96 mrna expression
97 fas ligand
98 il-10
99 stat3 signaling
100 necrosis factor related
101 ikappab kinase
102 jun n terminal
103 stat signaling
104 obliteran organizing pneumonia
105 cytotoxic activity
106 cell cycle arrest
107 homology modeling
108 intraepithelial
109 interferon regulatory
110 adenovirus vector
111 nf
112 hbv
113 bronchiolitis obliteran organizing
114 jak stat signaling
115 liver disease
116 baff
117 cd8 t cell
118 hiv
119 cd4 cd25 regulatory
120 proapoptotic
121 cd8
122 caspase-3
123 cloning expression characterization
124 bax bak
125 attenuated salmonella
126 double stranded
127 marek disease virus
128 cd8 t
129 expression profiling
130 adenovirus
131 c jun n
132 ikappab
133 monoclonal antibody
134 chaperone
135 molecular dynamic study
136 idiotype
137 tumor suppressor
138 electron cryomicroscopy
139 promoter
140 chromogenic situ
141 lymphokine
142 transcriptase polymerase chain
143 seroprevalence
144 expression characterization
145 apoptosis
146 cd25 regulatory t
147 cytokine gene expression
148 cdna
149 chromogenic situ hybridization
150 serum immunoglobulin
151 deletion polymorphism
152 thyroid
153 apoptosis inducing
154 polymorphism
155 hepatitis c virus
156 fas mediated
157 gene encoding
158 erythroleukemia cell
159 sclerosing
160 chicken anemia virus
161 bursal
162 gene therapy malignant
163 bax
164 initiation factor
165 factor receptor
166 apoptotic signaling
167 enterotoxigenic escherichia coli
168 bioinformatic
169 defensin
170 plasmid
171 dendritic cell
172 bronchiolitis obliteran
173 autophagy
174 n terminal kinase
175 hepatocellular
176 activation p38
177 tobacco
178 sentinel
179 killer
180 e3l
181 pro apoptotic bcl-2
182 transcription
183 dna vaccination
184 akt activation
185 binding motif
186 stat signaling pathway
187 transformed
188 caspase dependent pathway
189 newcastle disease
190 crystal structure
191 retroviral vector
192 dna vaccine
193 tlr7
194 inflammasome
195 integrase
196 bladder cancer
197 caspase-3 activation
198 interferon beta
199 cryptosporidiosis
200 protein protein interface
201 genomic
202 rt pcr
203 thymoma
204 translation initiation
205 recombinant plasmid
206 cancer cell down
207 transcription factor
208 ddx1
209 profiling
210 capsid
211 interferon regulatory factor
212 hepatitis c
213 dna binding
214 death receptor mediated
215 akt nf
216 nucleolin
217 apoptotic pathway
218 monoclonal antibody based
219 atadenovirus
220 mitogen
221 bile duct
222 reverse transcription pcr
223 transcription factor nf
224 mrna
225 cytotoxic t lymphocyte
226 egyptian propolis
227 coxsackievirus
228 hepatoma
229 beta1 integrin
230 hsp90
231 interferon signaling
232 consensus interferon
233 crystal
234 gene expression
235 eif4e
236 marek disease vaccine
237 real time
238 diabetes
239 biliary
240 dna damage signaling
241 cholangitis
242 ifn gamma
243 viral capsid
244 smac
245 anti inflammatory cytokine
246 hematopoietic
247 pituitary
248 cd4 cd25
249 t cell
250 g1
251 vaccinia virus e3l
252 natural killer cell
253 akt nf kappab
254 m cell cycle
255 epstein barr virus
256 epstein barr
257 identification expression
258 mitogen activated
259 vesicular stomatitis virus
260 stranded
261 trail resistant
262 engineered
263 monoclonal
264 psoralen
265 protein phosphorylation
266 receptor gene
267 hepatitis
268 il-8
269 microtubule associated protein
270 chicken anemia
271 toll
272 mediated trail
273 killer cell
274 situ hybridization
275 cytokine production
276 human dendritic cell
277 transcriptional
278 ctl
279 cd4 cd8 t
280 expressed escherichia coli
281 nf kappab dependent
282 reverse transcriptase polymerase
283 polymerase
284 icos
285 mhc class
286 microcarrier
287 cell cycle
288 m cell
289 mass spectrometry
290 cytokine response
291 cancer cell
292 monoclonal anti
293 structural basis
294 apoptosis mediated
295 pcr assay detection
296 factor kappa b
297 specific antigen
298 magnetic resonance imaging
299 cik cell
300 reverse transcription
301 cytokine gene
302 resonance imaging
303 t cell receptor
304 t cell response
305 anti idiotypic
306 rac1
307 nuclear factor kappa
308 natural killer
309 interferon regulatory factor-1
310 cell death
311 genome
312 structural insight
313 polymorphism haplotype
314 cytotoxicity
315 vector
316 shrna
317 rt
318 activation death receptor
319 18f
320 molecular chaperone
321 dendritic
322 gene therapy
323 monoclonal antibody specific
324 microfluidic
325 cd56
326 nested pcr
327 crystal structure human
328 cell response
329 rupture
330 formalin fixed paraffin
331 embryo transfer
332 echovirus
333 apoptosis related
334 delivered attenuated salmonella
335 m cell targeting
336 myocarditis
337 amp activated protein
338 molecular evolution
339 rna binding protein
340 feline
341 insect cell
342 nude mice
343 cytomegalovirus dna
344 jun
345 targeting
346 polyclonal antibody
347 factor nf
348 mediated caspase
349 gastric cancer
350 eif-4e
351 down regulation
352 rna
353 hepatobiliary
354 elongation factor
355 deoxynivalenol
356 ccr5
357 kappa
358 cd25
359 ras signaling
360 translation
361 tlr
362 reverse transcriptase
363 cytomegalovirus
364 newcastle
365 cytotoxic t cell
366 g m cell
367 il-15
368 epidermal
369 idiotypic
370 death receptor
371 acute respiratory distress
372 vp1
373 virotherapy
374 stat
375 adenovirus vector a
376 mediated apoptosis
377 cpg oligodeoxynucleotide
378 encephalitis
379 regulatory t
380 laser
381 newcastle disease virus
382 novel human
383 promoter activity
384 activation p38 mapk
385 chinese hamster lung
386 targeted
387 apoptosis induced
388 human cytomegalovirus
389 pichia pastoris
390 core protein
391 domain
392 chinese
393 scid mice
394 endonuclease
395 silencing
396 expression system
397 hydrocephalus
398 apoptosis induction
399 vaccinia virus
400 association polymorphism
401 colon adenocarcinoma cell
402 mortality
403 methylation
404 immunosuppression
405 cytotoxic
406 3-deazaneplanocin a
407 rna binding
408 protein kinase
409 apoptotic bcl-2
410 organizing pneumonia
411 inducible gene
412 marrow derived macrophage
413 bone morphogenetic protein
414 carcinoma cell
415 microenvironment
416 blocked bcl-2
417 immunodeficiency
418 dendrimer
419 apoptotic bcl-2 protein
420 il-4
421 role interferon regulatory
422 diffuse alveolar
423 efficacy interferon
424 situ hybridization immunohistochemistry
425 tobacco smoke
426 major capsid
427 aminoglycoside
428 retrospective study
429 cd43
430 bladder cancer a
431 kinase c delta
432 polymorphism susceptibility
433 proanthocyanidin
434 intercellular adhesion molecule-1
435 expression apoptosis
436 apoptosis dna repair
437 chain reaction assay
438 interferon
439 pancreatic beta cell
440 p53-dependent apoptosis
441 mediated gene therapy
442 intercellular adhesion
443 infected cell
444 oncolytic virus
445 protein involved
446 specific cytotoxic t
447 therapy malignant glioma
448 synthesis biological
449 protein kinase mapk
450 e6
451 pancreatic beta
452 recombination
453 elisa
454 stranded rna
455 cpg
456 transcriptase
457 pancreatitis
458 bluetongue virus
459 bcl-2 protein
460 epitope
461 proapoptotic peptide
462 bone morphogenetic
463 translational efficiency
464 kappa b
465 cytokine human
466 pi 3-kinase
467 fixed paraffin embedded
468 salivary gland
469 double stranded rna
470 colorectal
471 pancreatic
472 apoptosis cultured
473 modeling
474 eif2alpha
475 adenovirus e1b
476 autoimmunity
477 nitric oxide
478 duct
479 qpcr
480 cytotoxic cell
481 exocrine pancreas
482 s6
483 hepatocarcinoma cell
484 suppressor
485 parainfluenza-3
486 esophageal
487 tlr3
488 musculoskeletal
489 disease virus
490 ifn alpha
491 scid
492 oncogene
493 enzyme linked immunosorbent
494 b cell
495 fusion protein
496 chorioallantoic membrane
497 distress syndrome
498 rhinosinusitis
499 clathrin
500 mutational analysis
501 endothelial
502 deletion mutant
503 imaging
504 nasal
505 oxidative damage
506 erythroleukemia
507 hematopoietic cell
508 cell surface
509 expression profile
510 chronic hepatitis
511 myxoma virus
512 cell tropism
513 cdc2
514 pro apoptotic
515 adam10
516 microtubule
517 lymphoma
518 p38 signaling pathway
519 jnk dependent
520 colorectal carcinoma
521 linked immunosorbent assay
522 trimerization domain
523 helicase
524 thermosensitive
525 reconstruction
526 insulin
527 etching
528 immunohistochemistry situ
529 nadph oxidase
530 myeloid dendritic cell
531 immunohistochemical
532 molecular detection
533 mutation
534 kinase
535 dot blot
536 cap dependent translation
537 calpain
538 bicistronic
539 rna polymerase
540 lymphocyte
541 codon
542 disease free
543 pcr method
544 oncolysis
545 nf kappa b
546 biliary tract
547 mhc
548 s-1
549 interleukin-4
550 inhibitor apoptosis protein
551 parvovirus a
552 rna replicase
553 bronchiolitis
554 cap dependent
555 myeloid
556 polyoma
557 colon
558 tendon sheath
559 activation nf kappab
560 cell activation
561 effect transforming growth
562 ifn
563 thyroglobulin antibody
564 tendon
565 cd4 t cell
566 novel oncogene
567 mdck cell
568 mitochondrial mediated
569 repair gene
570 prospective study
571 transfected
572 cd4 t
573 mhc class i
574 e1b
575 inhibitor apoptosis
576 protein kinase pathway
577 palmitoylation
578 lymphocyte function
579 murine natural killer
580 formalin fixed
581 cell subset
582 risk factor
583 jaundice
584 src kinase
585 hsp70
586 proapoptotic protein
587 polymeric immunoglobulin receptor
588 database
589 recombinant protein
590 follicular
591 vaccination
592 colorectal carcinoma cell
593 cd56 t cell
594 dendritic cell subset
595 construction recombinant
596 cancer a
597 fluoroquinolone derivative
598 directed
599 beta adrenergic receptor
600 bone marrow
601 crystallographic
602 beta cell
603 phase cell cycle
604 histone
605 trna
606 marrow
607 anti thyroglobulin antibody
608 slice culture
609 mouse model
610 vaccine
611 murine hepatocarcinoma
612 thymosin
613 novel proapoptotic
614 mitochondrial
615 respiratory epithelial
616 bak
617 ifnar
618 carcinoma
619 quantitative pcr
620 epithelial
621 fas
622 neonatal hepatitis
623 t lymphocyte
624 capture
625 immune system
626 immunosorbent assay elisa
627 retrospective
628 experimental autoimmune encephalomyelitis
629 replicative
630 ligand
631 cell receptor beta
632 pkr mediated
633 gastrointestinal
634 killer dendritic cell
635 effect cyclosporine
636 ms2
637 serological
638 embryo
639 oligomerization
640 growth factor
641 lineage
642 hepatocarcinoma
643 adhesion molecule icam
644 adhesion molecule
645 kinase signalling
646 antimicrobial peptide
647 targeting facilitate
648 attachment protein
649 virus entry
650 ifn beta
651 immunity
652 transformed cell
653 integrin
654 activation nf
655 anti thymocyte
656 myelitis
657 macrophage
658 cpg odn
659 igf
660 activation antigen
661 induce apoptosis cultured
662 restriction vaccinia virus
663 rel
664 antiproliferative
665 tumor cell
666 tumor suppressor gene
667 cell line
668 bacteriophage
669 complex adaptor
670 immunodeficient mice
671 small interfering
672 u937 cell
673 double positive
674 dominant negative
675 regulatory
676 glioma
677 p53 pathway
678 hiv-1
679 peritoneal
680 mammalian cell
681 constrained
682 cholestasis
683 glycoprotein mediated
684 protein a
685 pkr
686 invasion
687 transcriptional activity
688 cellular immune
689 colon adenocarcinoma
690 intestinal epithelial
691 expression brain
692 dependent protein kinase
693 mucosal
694 allograft
695 ionizing
696 vitamin
697 islet cell
698 infection cancer
699 fusion
700 replicase
701 role transcription factor
702 necrosis
703 antimicrobial activity
704 protein signaling
705 t cell precursor
706 interleukin-2
707 otitis media
708 transgene
709 two initiation site
710 coiled coil
711 mediated lysis
712 central nervous system
713 g m phase
714 t helper
715 syngeneic
716 ribosomal
717 hepatoma cell
718 lymphoblastoid
719 regulate
720 ra
721 kinase pathway
722 measle
723 prediction
724 osteoporosis
725 igm
726 required
727 microscopy
728 virion
729 adenosine
730 acute respiratory disease
731 antitumor
732 autocrine
733 thymocyte
734 islet
735 discovery
736 fusogenic
737 viral
738 replication protein
739 virus vaccine
740 retinoic acid inducible
741 proliferation
742 k562
743 hematology
744 gtpase
745 ribosome
746 mediated caspase dependent
747 hl60 cell
748 arrest
749 associated lymphoid tissue
750 stomatitis
751 poly
752 irradiation
753 german
754 helper t
755 dietary
756 extrahepatic
757 facial nerve
758 construction
759 dna binding protein
760 live cell imaging
761 induced hamster
762 capping protein
763 cathepsin b
764 translational control
765 pulmonary
766 head
767 heart
768 renal
769 src
770 lipid
771 panleukopenia
772 image
773 conformationally constrained
774 identification a novel
775 arthritis
776 burkitt lymphoma
777 intercellular adhesion molecule
778 c virus low
779 viral hepatitis
780 apoptosis protein
781 characterization temperature
782 neutrophil elastase
783 hybrid
784 shock
785 genomic dna
786 tumor necrosis factor
787 cell targeting
788 giant
789 inhibition nf
790 extrahepatic biliary
791 synthesis antiviral
792 liposome
793 synthetase
794 rna structure
795 range restriction vaccinia
796 nucleoside analogue
797 rhoa
798 multiscale
799 biliary atresia
800 precursor cytotoxic
801 related infection
802 cellular immune response
803 gerbil mouse
804 methyltransferase
805 qrt pcr
806 minocycline
807 activation transcription factor
808 dsrna
809 situ
810 murine
811 associated diarrhea
812 lymphoproliferation
813 infantile
814 3'-diindolylmethane
815 granulocyte macrophage
816 avian
817 purging
818 dna repair gene
819 ethnicity
820 intestinal
821 antibody
822 minor capsid protein
823 p65
824 erbb
825 prostaglandin h
826 cik
827 validation
828 leukocyte
829 prevalence
830 mapk kinase
831 angle x ray
832 hsp25
833 fibroblast cell
834 receptor signaling
835 dependent translation
836 tyrosine
837 basal expression
838 chicken
839 resistant
840 murine monoclonal
841 spindle
842 induced g m
843 mrna translation
844 cardiac
845 t cell subpopulation
846 herniation
847 survival
848 single base
849 plus
850 regulation expression
851 history
852 expression level
853 neck
854 specific cd4
855 minor capsid
856 bladder
857 nzb
858 respiratory virus
859 assay detection
860 intestinal epithelial cell
861 herpes simplex virus
862 analysis full
863 coxsackie
864 hct116
865 synthesis biological evaluation
866 protein coding
867 interleukin-4 il-4
868 fibrosis
869 immunocompetence
870 rna dependent rna
871 western blot
872 inos expression
873 chaperone function
874 nude
875 mammalian
876 effect interferon
877 coding region
878 immune
879 lymphocyte proliferation
880 activated protein
881 interferon gamma
882 small gtpase
883 magnetic resonance
884 amyloid
885 cell oncolytic
886 monoclonal antibody directed
887 t lymphocyte response
888 identification characterization a
889 retinoic acid
890 ubiquitination
891 specific t
892 lung
893 polymerase chain reaction
894 mcp-1
895 calpain inhibitor
896 uv
897 induced apoptosis mediated
898 major capsid protein
899 virus replication
900 immunodeficiency virus infection
901 endocytosis
902 independent pathway
903 prospective

Science医学:新型癌症病毒疗法
 
 研究人员发现了一种有前景的病毒治疗对癌症提供了双重打击,通过搭乘血细胞的便车可以偷偷地靠近未被检测到的肿瘤。相关论文发布在《科学转化医学》(Science Translational Medicine)杂志上。
 
 
 


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